The recombinant EGFR/CD13 bi-targeted fusion protein induces apoptosis and blocks tube formation

Previously it was shown that the recombinant EGFR/CD13 bi-targeted fusion protein ER(Fv)-LDP-NGR which consists of an anti-EGFR scFv antibody fragment, a tri-cyclic NGR peptide, and a lidamycin-derived apoprotein, inhibited the proliferation of cancer cells and markedly suppressed tumor growth of br...

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Veröffentlicht in:	Oncology reports 2017-12, Vol.38 (6), p.3507-3514
Hauptverfasser:	Sheng, Weijin, Gong, Jianhua, Jiang, Min, Zhen, Yongsu
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Angiogenesis antitumor Apoptosis bi-targeted Breast cancer Cancer Cancer treatment CD13 CD13 Antigens - genetics CD13 Antigens - metabolism Cell adhesion & migration Cell cycle Cell Cycle - drug effects Cell growth Cell Line Cell Movement - drug effects Cell Proliferation - drug effects Down-Regulation Drug therapy EGFR Extracellular matrix Fusion proteins Genetic aspects Health aspects Humans Immunoglobulins Innovations Kinases Ligands Lung cancer MCF-7 Cells Molecular targeted therapy multi-functional Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Oligopeptides - genetics Oligopeptides - metabolism Penicillin Peptides Phosphorylation Polymerase chain reaction Proteins Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - pharmacology Rodents Signal Transduction - drug effects Single-Chain Antibodies - genetics Single-Chain Antibodies - metabolism Transcription, Genetic - drug effects
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