Molecular alterations of the NF2 gene in hepatocellular carcinoma and intrahepatic cholangiocarcinoma

Neurofibromatosis type 2 with mutations in the neurofibromin 2 (NF2) gene, encoding the Merlin protein, is an autosomal dominant disorder characterized by enhanced cancer predisposition, particularly tumors of the central nervous system. Recent animal studies indicate that disruption of NF2/Merlin f...

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