Highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides

Herein, we report a highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides. Not only does this transformation provide access to versatile fluorinated building blocks that were difficult or hardly possible to access beforehand, but it also represents a rare case of a hig...

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Veröffentlicht in:	Organic & biomolecular chemistry 2017, Vol.15 (46), p.9830-9836
Hauptverfasser:	Hamel, Jean-Denys, Hayashi, Tatsuru, Cloutier, Mélissa, Savoie, Paul R, Thibeault, Olivier, Beaudoin, Meggan, Paquin, Jean-François
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Catalysis Difluorides Fluorination Gold Hydration Regioselectivity
Online-Zugang:	Volltext
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