Wheat allergen exposure and the prevalence of work-related sensitization and allergy in bakery workers
Occupational airway diseases are common among bakers. The present study describes the association between exposure to wheat allergen levels and sensitization to wheat allergens, work-related upper and lower respiratory symptoms and asthma in bakery workers. As part of a Health Surveillance System fo...
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| Veröffentlicht in: | Allergy 2008-12, Vol.63 (12), p.1597-1604 |
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| creator | Jacobs, J.H Meijster, T Meijer, E Suarthana, E Heederik, D |
| description | Occupational airway diseases are common among bakers. The present study describes the association between exposure to wheat allergen levels and sensitization to wheat allergens, work-related upper and lower respiratory symptoms and asthma in bakery workers. As part of a Health Surveillance System for early detection of (allergic) occupational airway diseases a so-called 'validation study' was performed among Dutch bakers for validation of a diagnostic model that predict the likelihood of sensitization to specific workplace allergens. The present study used serology and questionnaire results of a subgroup of 860 bakers participating in the validation study. An earlier developed job-exposure matrix was used to predict average and cumulative personal exposure to wheat allergens. The prevalence of wheat sensitization, work-related respiratory symptoms and asthma increased till average wheat exposure levels of approximately 25-30 μg/m³, leveled off and decreased at higher exposure concentrations. Exposure-response curves showed a stronger pronounced bell-shape with cumulative exposure. Associations were strongest for asthma and work-related lower respiratory symptoms (PR~2 and PR~3.5-4.5 for average and cumulative exposure, respectively). Associations were only found in atopics. Wheat sensitization was an important factor in the prevalence of respiratory symptoms. In accordance with earlier studies, the present study showed a bell-shaped exposure-response relationship especially for cumulative wheat allergen exposure with sensitization, allergic respiratory symptoms and asthma. The healthy worker effect may be the possible explanation for the bell-shaped relationship. |
| doi_str_mv | 10.1111/j.1398-9995.2008.01698.x |
| format | Article |
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The present study describes the association between exposure to wheat allergen levels and sensitization to wheat allergens, work-related upper and lower respiratory symptoms and asthma in bakery workers. As part of a Health Surveillance System for early detection of (allergic) occupational airway diseases a so-called 'validation study' was performed among Dutch bakers for validation of a diagnostic model that predict the likelihood of sensitization to specific workplace allergens. The present study used serology and questionnaire results of a subgroup of 860 bakers participating in the validation study. An earlier developed job-exposure matrix was used to predict average and cumulative personal exposure to wheat allergens. The prevalence of wheat sensitization, work-related respiratory symptoms and asthma increased till average wheat exposure levels of approximately 25-30 μg/m³, leveled off and decreased at higher exposure concentrations. Exposure-response curves showed a stronger pronounced bell-shape with cumulative exposure. Associations were strongest for asthma and work-related lower respiratory symptoms (PR~2 and PR~3.5-4.5 for average and cumulative exposure, respectively). Associations were only found in atopics. Wheat sensitization was an important factor in the prevalence of respiratory symptoms. In accordance with earlier studies, the present study showed a bell-shaped exposure-response relationship especially for cumulative wheat allergen exposure with sensitization, allergic respiratory symptoms and asthma. The healthy worker effect may be the possible explanation for the bell-shaped relationship.</description><identifier>ISSN: 0105-4538</identifier><identifier>EISSN: 1398-9995</identifier><identifier>EISSN: 0108-1675</identifier><identifier>DOI: 10.1111/j.1398-9995.2008.01698.x</identifier><identifier>PMID: 18513267</identifier><identifier>CODEN: LLRGDY</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Allergens - adverse effects ; Allergens - immunology ; Allergies ; Antigens, Plant - adverse effects ; Antigens, Plant - immunology ; Asthma ; Bakeries ; Biological and medical sciences ; Cooking ; Cross-Sectional Studies ; Dust - immunology ; Flour ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Hypersensitivity - epidemiology ; Hypersensitivity - immunology ; Immunization - trends ; Medical sciences ; Middle Aged ; Occupational Diseases - epidemiology ; Occupational Diseases - immunology ; Occupational health ; occupational sensitization ; Prevalence ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Triticum - immunology ; Triticum aestivum ; Validation studies ; Wheat ; wheat allergen exposure ; work-related respiratory symptoms ; Young Adult</subject><ispartof>Allergy, 2008-12, Vol.63 (12), p.1597-1604</ispartof><rights>2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard</rights><rights>2009 INIST-CNRS</rights><rights>Journal compilation © 2008 Blackwell Munksgaard</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5468-108c46753f34faf4a34a1f80627cf235e784e51baf447d42bf3459a06f9a0b6c3</citedby><cites>FETCH-LOGICAL-c5468-108c46753f34faf4a34a1f80627cf235e784e51baf447d42bf3459a06f9a0b6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1398-9995.2008.01698.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1398-9995.2008.01698.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20845823$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18513267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jacobs, J.H</creatorcontrib><creatorcontrib>Meijster, T</creatorcontrib><creatorcontrib>Meijer, E</creatorcontrib><creatorcontrib>Suarthana, E</creatorcontrib><creatorcontrib>Heederik, D</creatorcontrib><title>Wheat allergen exposure and the prevalence of work-related sensitization and allergy in bakery workers</title><title>Allergy</title><addtitle>Allergy</addtitle><description>Occupational airway diseases are common among bakers. The present study describes the association between exposure to wheat allergen levels and sensitization to wheat allergens, work-related upper and lower respiratory symptoms and asthma in bakery workers. As part of a Health Surveillance System for early detection of (allergic) occupational airway diseases a so-called 'validation study' was performed among Dutch bakers for validation of a diagnostic model that predict the likelihood of sensitization to specific workplace allergens. The present study used serology and questionnaire results of a subgroup of 860 bakers participating in the validation study. An earlier developed job-exposure matrix was used to predict average and cumulative personal exposure to wheat allergens. The prevalence of wheat sensitization, work-related respiratory symptoms and asthma increased till average wheat exposure levels of approximately 25-30 μg/m³, leveled off and decreased at higher exposure concentrations. Exposure-response curves showed a stronger pronounced bell-shape with cumulative exposure. Associations were strongest for asthma and work-related lower respiratory symptoms (PR~2 and PR~3.5-4.5 for average and cumulative exposure, respectively). Associations were only found in atopics. Wheat sensitization was an important factor in the prevalence of respiratory symptoms. In accordance with earlier studies, the present study showed a bell-shaped exposure-response relationship especially for cumulative wheat allergen exposure with sensitization, allergic respiratory symptoms and asthma. The healthy worker effect may be the possible explanation for the bell-shaped relationship.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Allergens - adverse effects</subject><subject>Allergens - immunology</subject><subject>Allergies</subject><subject>Antigens, Plant - adverse effects</subject><subject>Antigens, Plant - immunology</subject><subject>Asthma</subject><subject>Bakeries</subject><subject>Biological and medical sciences</subject><subject>Cooking</subject><subject>Cross-Sectional Studies</subject><subject>Dust - immunology</subject><subject>Flour</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Hypersensitivity - epidemiology</subject><subject>Hypersensitivity - immunology</subject><subject>Immunization - trends</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Occupational Diseases - epidemiology</subject><subject>Occupational Diseases - immunology</subject><subject>Occupational health</subject><subject>occupational sensitization</subject><subject>Prevalence</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Triticum - immunology</subject><subject>Triticum aestivum</subject><subject>Validation studies</subject><subject>Wheat</subject><subject>wheat allergen exposure</subject><subject>work-related respiratory symptoms</subject><subject>Young Adult</subject><issn>0105-4538</issn><issn>1398-9995</issn><issn>0108-1675</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EotvCXwALid6yjD9jHzhUFV_SShyg4mg52XGbbTZZ7ITu8utxNqsiccIH29I87zujeQmhDJYsn3ebJRPWFNZateQAZglMW7PcPyGLx8JTsgAGqpBKmDNyntIGAEpu4Tk5Y0YxwXW5IOHHHfqB-rbFeIsdxf2uT2NE6rs1He6Q7iL-8i12NdI-0Ic-3hcRWz_gmibsUjM0v_3Q9N1RMNscaNPRyt9jPBwFGNML8iz4NuHL03tBbj5--H79uVh9_fTl-mpV1EpqUzAwtdSlEkHI4IP0QnoWDGhe1oELhaWRqFiVS7JcS15lTlkPOuSr0rW4IJez7y72P0dMg9s2qca29R32Y3LMasGNFhl88w-46cfY5dkmxoIFkBkyM1THPqWIwe1is_Xx4Bi4KQi3cdO-3bRvNwXhjkG4fZa-OvmP1RbXf4WnzWfg7QnwqfZtiL6rm_TIcTBSGT4N-n7mHpoWD_89gLtaraZf1r-e9cH3zt_G3OPmGwcmgCkNVnDxB2t8rYE</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Jacobs, J.H</creator><creator>Meijster, T</creator><creator>Meijer, E</creator><creator>Suarthana, E</creator><creator>Heederik, D</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>200812</creationdate><title>Wheat allergen exposure and the prevalence of work-related sensitization and allergy in bakery workers</title><author>Jacobs, J.H ; Meijster, T ; Meijer, E ; Suarthana, E ; Heederik, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5468-108c46753f34faf4a34a1f80627cf235e784e51baf447d42bf3459a06f9a0b6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Allergens - adverse effects</topic><topic>Allergens - immunology</topic><topic>Allergies</topic><topic>Antigens, Plant - adverse effects</topic><topic>Antigens, Plant - immunology</topic><topic>Asthma</topic><topic>Bakeries</topic><topic>Biological and medical sciences</topic><topic>Cooking</topic><topic>Cross-Sectional Studies</topic><topic>Dust - immunology</topic><topic>Flour</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Hypersensitivity - epidemiology</topic><topic>Hypersensitivity - immunology</topic><topic>Immunization - trends</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Occupational Diseases - epidemiology</topic><topic>Occupational Diseases - immunology</topic><topic>Occupational health</topic><topic>occupational sensitization</topic><topic>Prevalence</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Triticum - immunology</topic><topic>Triticum aestivum</topic><topic>Validation studies</topic><topic>Wheat</topic><topic>wheat allergen exposure</topic><topic>work-related respiratory symptoms</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jacobs, J.H</creatorcontrib><creatorcontrib>Meijster, T</creatorcontrib><creatorcontrib>Meijer, E</creatorcontrib><creatorcontrib>Suarthana, E</creatorcontrib><creatorcontrib>Heederik, D</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jacobs, J.H</au><au>Meijster, T</au><au>Meijer, E</au><au>Suarthana, E</au><au>Heederik, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wheat allergen exposure and the prevalence of work-related sensitization and allergy in bakery workers</atitle><jtitle>Allergy</jtitle><addtitle>Allergy</addtitle><date>2008-12</date><risdate>2008</risdate><volume>63</volume><issue>12</issue><spage>1597</spage><epage>1604</epage><pages>1597-1604</pages><issn>0105-4538</issn><eissn>1398-9995</eissn><eissn>0108-1675</eissn><coden>LLRGDY</coden><abstract>Occupational airway diseases are common among bakers. The present study describes the association between exposure to wheat allergen levels and sensitization to wheat allergens, work-related upper and lower respiratory symptoms and asthma in bakery workers. As part of a Health Surveillance System for early detection of (allergic) occupational airway diseases a so-called 'validation study' was performed among Dutch bakers for validation of a diagnostic model that predict the likelihood of sensitization to specific workplace allergens. The present study used serology and questionnaire results of a subgroup of 860 bakers participating in the validation study. An earlier developed job-exposure matrix was used to predict average and cumulative personal exposure to wheat allergens. The prevalence of wheat sensitization, work-related respiratory symptoms and asthma increased till average wheat exposure levels of approximately 25-30 μg/m³, leveled off and decreased at higher exposure concentrations. Exposure-response curves showed a stronger pronounced bell-shape with cumulative exposure. Associations were strongest for asthma and work-related lower respiratory symptoms (PR~2 and PR~3.5-4.5 for average and cumulative exposure, respectively). Associations were only found in atopics. Wheat sensitization was an important factor in the prevalence of respiratory symptoms. In accordance with earlier studies, the present study showed a bell-shaped exposure-response relationship especially for cumulative wheat allergen exposure with sensitization, allergic respiratory symptoms and asthma. The healthy worker effect may be the possible explanation for the bell-shaped relationship.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>18513267</pmid><doi>10.1111/j.1398-9995.2008.01698.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Allergens - adverse effects Allergens - immunology Allergies Antigens, Plant - adverse effects Antigens, Plant - immunology Asthma Bakeries Biological and medical sciences Cooking Cross-Sectional Studies Dust - immunology Flour Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Hypersensitivity - epidemiology Hypersensitivity - immunology Immunization - trends Medical sciences Middle Aged Occupational Diseases - epidemiology Occupational Diseases - immunology Occupational health occupational sensitization Prevalence Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Triticum - immunology Triticum aestivum Validation studies Wheat wheat allergen exposure work-related respiratory symptoms Young Adult |
| title | Wheat allergen exposure and the prevalence of work-related sensitization and allergy in bakery workers |
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