Role of PTPN22 1858 C/T Polymorphisms in Juvenile Idiopathic Arthritis in Egyptian Patients

Role of PTPN22 1858 C/T Polymorphisms in Juvenile Idiopathic Arthritis in Egyptian Patients

Juvenile idiopathic arthritis (JIA) the most common chronic arthropathy of childhood is a diverse group of chronic arthritis diseases. The protein tyrosine phosphatase N22 (PTPN22) gene exhibits regulatory activities for both T and B cells. This study aimed to study PTPN gene polymorphism in JIA. Th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Egyptian journal of immunology 2017-01, Vol.24 (1), p.95-104
Hauptverfasser: Soliman, Yasser A, Hashaad, Nashwa I, Emam, Sherin M, Mohamed, Rehab R
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 104
container_issue 1
container_start_page 95
container_title The Egyptian journal of immunology
container_volume 24
creator Soliman, Yasser A
Hashaad, Nashwa I
Emam, Sherin M
Mohamed, Rehab R
description Juvenile idiopathic arthritis (JIA) the most common chronic arthropathy of childhood is a diverse group of chronic arthritis diseases. The protein tyrosine phosphatase N22 (PTPN22) gene exhibits regulatory activities for both T and B cells. This study aimed to study PTPN gene polymorphism in JIA. The study included 60 children with JIA and 40 age and sex matched healthy children as controls. Patients and control groups were subjected to PTPN gene polymorphism analysis. Our findings indicated a significant difference in PTPN22 polymorphism between JIA patients and the control group (P = 0.021). Different PTPN genotypes were studied in relation to patient's age, sex and relevant laboratory data. It was concluded that PTPN22 polymorphism is different in JIA patients than healthy controls. T allele is associated only in cases with JIA and it may be considered as risk allele for certain JIA subtypes.
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1963276188</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1963276188</sourcerecordid><originalsourceid>FETCH-LOGICAL-p126t-b226f712deab5324c26a3cc49f319dab571a27792d67d3557515f798a76921613</originalsourceid><addsrcrecordid>eNo10MFLwzAYBfAcFDfm_gXJ0Uux35cmaY5jTJ0MLVJPHkrWpC7SNrVJhf33Dp2nB48f7_AuyBwA0iRTKc7IMoTPNE0BuRRSXpEZKsCU5zgn76--tdQ3tCiLZ0QKOc_p-q6khW-PnR-HgwtdoK6nT9O37d0Jb43zg44HV9PVGA-ji-4XbD6OQ3S6p4WOzvYxXJPLRrfBLs-5IG_3m3L9mOxeHrbr1S4ZAEVM9oiikYDG6j1nmNUoNKvrTDUMlDl1EjRKqdAIaRjnkgNvpMq1FApBAFuQ27_dYfRfkw2x6lyobdvq3vopVKAEQykgz0_05kynfWdNNYyu0-Ox-j-E_QBBXVmM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1963276188</pqid></control><display><type>article</type><title>Role of PTPN22 1858 C/T Polymorphisms in Juvenile Idiopathic Arthritis in Egyptian Patients</title><source>Alma/SFX Local Collection</source><creator>Soliman, Yasser A ; Hashaad, Nashwa I ; Emam, Sherin M ; Mohamed, Rehab R</creator><creatorcontrib>Soliman, Yasser A ; Hashaad, Nashwa I ; Emam, Sherin M ; Mohamed, Rehab R</creatorcontrib><description>Juvenile idiopathic arthritis (JIA) the most common chronic arthropathy of childhood is a diverse group of chronic arthritis diseases. The protein tyrosine phosphatase N22 (PTPN22) gene exhibits regulatory activities for both T and B cells. This study aimed to study PTPN gene polymorphism in JIA. The study included 60 children with JIA and 40 age and sex matched healthy children as controls. Patients and control groups were subjected to PTPN gene polymorphism analysis. Our findings indicated a significant difference in PTPN22 polymorphism between JIA patients and the control group (P = 0.021). Different PTPN genotypes were studied in relation to patient's age, sex and relevant laboratory data. It was concluded that PTPN22 polymorphism is different in JIA patients than healthy controls. T allele is associated only in cases with JIA and it may be considered as risk allele for certain JIA subtypes.</description><identifier>ISSN: 1110-4902</identifier><identifier>PMID: 29120582</identifier><language>eng</language><publisher>Egypt</publisher><ispartof>The Egyptian journal of immunology, 2017-01, Vol.24 (1), p.95-104</ispartof><rights>Copyright© by the Egyptian Association of Immunologists.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29120582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soliman, Yasser A</creatorcontrib><creatorcontrib>Hashaad, Nashwa I</creatorcontrib><creatorcontrib>Emam, Sherin M</creatorcontrib><creatorcontrib>Mohamed, Rehab R</creatorcontrib><title>Role of PTPN22 1858 C/T Polymorphisms in Juvenile Idiopathic Arthritis in Egyptian Patients</title><title>The Egyptian journal of immunology</title><addtitle>Egypt J Immunol</addtitle><description>Juvenile idiopathic arthritis (JIA) the most common chronic arthropathy of childhood is a diverse group of chronic arthritis diseases. The protein tyrosine phosphatase N22 (PTPN22) gene exhibits regulatory activities for both T and B cells. This study aimed to study PTPN gene polymorphism in JIA. The study included 60 children with JIA and 40 age and sex matched healthy children as controls. Patients and control groups were subjected to PTPN gene polymorphism analysis. Our findings indicated a significant difference in PTPN22 polymorphism between JIA patients and the control group (P = 0.021). Different PTPN genotypes were studied in relation to patient's age, sex and relevant laboratory data. It was concluded that PTPN22 polymorphism is different in JIA patients than healthy controls. T allele is associated only in cases with JIA and it may be considered as risk allele for certain JIA subtypes.</description><issn>1110-4902</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNo10MFLwzAYBfAcFDfm_gXJ0Uux35cmaY5jTJ0MLVJPHkrWpC7SNrVJhf33Dp2nB48f7_AuyBwA0iRTKc7IMoTPNE0BuRRSXpEZKsCU5zgn76--tdQ3tCiLZ0QKOc_p-q6khW-PnR-HgwtdoK6nT9O37d0Jb43zg44HV9PVGA-ji-4XbD6OQ3S6p4WOzvYxXJPLRrfBLs-5IG_3m3L9mOxeHrbr1S4ZAEVM9oiikYDG6j1nmNUoNKvrTDUMlDl1EjRKqdAIaRjnkgNvpMq1FApBAFuQ27_dYfRfkw2x6lyobdvq3vopVKAEQykgz0_05kynfWdNNYyu0-Ox-j-E_QBBXVmM</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Soliman, Yasser A</creator><creator>Hashaad, Nashwa I</creator><creator>Emam, Sherin M</creator><creator>Mohamed, Rehab R</creator><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201701</creationdate><title>Role of PTPN22 1858 C/T Polymorphisms in Juvenile Idiopathic Arthritis in Egyptian Patients</title><author>Soliman, Yasser A ; Hashaad, Nashwa I ; Emam, Sherin M ; Mohamed, Rehab R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-b226f712deab5324c26a3cc49f319dab571a27792d67d3557515f798a76921613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Soliman, Yasser A</creatorcontrib><creatorcontrib>Hashaad, Nashwa I</creatorcontrib><creatorcontrib>Emam, Sherin M</creatorcontrib><creatorcontrib>Mohamed, Rehab R</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Egyptian journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soliman, Yasser A</au><au>Hashaad, Nashwa I</au><au>Emam, Sherin M</au><au>Mohamed, Rehab R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of PTPN22 1858 C/T Polymorphisms in Juvenile Idiopathic Arthritis in Egyptian Patients</atitle><jtitle>The Egyptian journal of immunology</jtitle><addtitle>Egypt J Immunol</addtitle><date>2017-01</date><risdate>2017</risdate><volume>24</volume><issue>1</issue><spage>95</spage><epage>104</epage><pages>95-104</pages><issn>1110-4902</issn><abstract>Juvenile idiopathic arthritis (JIA) the most common chronic arthropathy of childhood is a diverse group of chronic arthritis diseases. The protein tyrosine phosphatase N22 (PTPN22) gene exhibits regulatory activities for both T and B cells. This study aimed to study PTPN gene polymorphism in JIA. The study included 60 children with JIA and 40 age and sex matched healthy children as controls. Patients and control groups were subjected to PTPN gene polymorphism analysis. Our findings indicated a significant difference in PTPN22 polymorphism between JIA patients and the control group (P = 0.021). Different PTPN genotypes were studied in relation to patient's age, sex and relevant laboratory data. It was concluded that PTPN22 polymorphism is different in JIA patients than healthy controls. T allele is associated only in cases with JIA and it may be considered as risk allele for certain JIA subtypes.</abstract><cop>Egypt</cop><pmid>29120582</pmid><tpages>10</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1110-4902
ispartof The Egyptian journal of immunology, 2017-01, Vol.24 (1), p.95-104
issn 1110-4902
language eng
recordid cdi_proquest_miscellaneous_1963276188
source Alma/SFX Local Collection
title Role of PTPN22 1858 C/T Polymorphisms in Juvenile Idiopathic Arthritis in Egyptian Patients
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T19%3A29%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20PTPN22%201858%20C/T%20Polymorphisms%20in%20Juvenile%20Idiopathic%20Arthritis%20in%20Egyptian%20Patients&rft.jtitle=The%20Egyptian%20journal%20of%20immunology&rft.au=Soliman,%20Yasser%20A&rft.date=2017-01&rft.volume=24&rft.issue=1&rft.spage=95&rft.epage=104&rft.pages=95-104&rft.issn=1110-4902&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1963276188%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1963276188&rft_id=info:pmid/29120582&rfr_iscdi=true