5-Fluorouracil-loaded chitosan coated polylactic acid microspheres as biodegradable drug carriers for cerebral tumours

The development of injectable microspheres for anticancer drug delivery into the brain is a major challenge. The possibility of entrapping 5-fluorouracil (5-FU) in chitosan coated monodisperse biodegradable microspheres with a mean diameter of 10-25um was demonstrated. An emulsion of 5-FU (in water)...

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Veröffentlicht in:	Journal of microencapsulation 2000-09, Vol.17 (5), p.625-638
Hauptverfasser:	CHANDY, T, DAS, G. S, RAO, G. H. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - therapeutic use Antineoplastic agents Biodegradation, Environmental Biological and medical sciences Brain Neoplasms - drug therapy Capsules Chemotherapy Chitin - analogs & derivatives Chitosan Drug Carriers Drug Compounding - methods Fluorouracil - administration & dosage Fluorouracil - therapeutic use General pharmacology Glioma - drug therapy Humans Lactic Acid Medical sciences Microscopy, Electron, Scanning Microspheres Microspheres Drugdelivery Poly-LACTICACID Chitosan Poly Lactideco-GLYCOLIDE Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyesters Polymers
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