Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice

Tumor cells can maintain their growth via immunosuppression and escape from host antitumor immunity by controlling the PD-1/PD-L1 system. Expression of PD-L1 (CD274) is an inhibitory signal for T cells, while the increase in CD326 expression in the tumor tissue correlates with metastasis development...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2017-11, Vol.164 (1), p.102-105
Hauptverfasser:	Lopatina, K. A., Safonova, E. A., Nevskaya, K. V., Stakheeva, M. N., Gur’ev, A. M., Zueva, E. P., Razina, T. G., Amosova, E. N., Krylov, S. G., Belousov, M. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acorus - chemistry Acorus calamus Animals Antigens Antineoplastic Agents, Phytogenic - administration & dosage Antitumor activity B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Biomedical and Life Sciences Biomedicine Carcinoma, Lewis Lung - drug therapy Carcinoma, Lewis Lung - metabolism Carcinoma, Lewis Lung - pathology Cell Biology Cell Line, Tumor Epithelial Cell Adhesion Molecule - genetics Epithelial Cell Adhesion Molecule - metabolism Female Flow cytometry Immunosuppression Internal Medicine Laboratory Medicine Lung cancer Lung carcinoma Lung transplantation Lymphocytes T Metastases Mice, Inbred C57BL Pathology PD-1 protein PD-L1 protein Plant Extracts - pharmacology Plant Roots - chemistry Rats Rodents Tumor Burden Tumor cells Xenograft Model Antitumor Assays
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