Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice
Tumor cells can maintain their growth via immunosuppression and escape from host antitumor immunity by controlling the PD-1/PD-L1 system. Expression of PD-L1 (CD274) is an inhibitory signal for T cells, while the increase in CD326 expression in the tumor tissue correlates with metastasis development...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2017-11, Vol.164 (1), p.102-105 |
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| creator | Lopatina, K. A. Safonova, E. A. Nevskaya, K. V. Stakheeva, M. N. Gur’ev, A. M. Zueva, E. P. Razina, T. G. Amosova, E. N. Krylov, S. G. Belousov, M. V. |
| description | Tumor cells can maintain their growth via immunosuppression and escape from host antitumor immunity by controlling the PD-1/PD-L1 system. Expression of PD-L1 (CD274) is an inhibitory signal for T cells, while the increase in CD326 expression in the tumor tissue correlates with metastasis development. The experimental preparation on the basis of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan from
Acorus calamus L.
produces an antitumor effect: it reduces tumor node size and the number and area of metastases after transplantation of Lewis lung carcinoma. Using flow cytometry, we demonstrated a decrease in the population of tumor cells expressing surface CD274 (PD-L1) and CD326 antigens after 20-day course of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan. |
| doi_str_mv | 10.1007/s10517-017-3934-4 |
| format | Article |
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Acorus calamus L.
produces an antitumor effect: it reduces tumor node size and the number and area of metastases after transplantation of Lewis lung carcinoma. Using flow cytometry, we demonstrated a decrease in the population of tumor cells expressing surface CD274 (PD-L1) and CD326 antigens after 20-day course of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-017-3934-4</identifier><identifier>PMID: 29124538</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acorus - chemistry ; Acorus calamus ; Animals ; Antigens ; Antineoplastic Agents, Phytogenic - administration & dosage ; Antitumor activity ; B7-H1 Antigen - genetics ; B7-H1 Antigen - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Carcinoma, Lewis Lung - drug therapy ; Carcinoma, Lewis Lung - metabolism ; Carcinoma, Lewis Lung - pathology ; Cell Biology ; Cell Line, Tumor ; Epithelial Cell Adhesion Molecule - genetics ; Epithelial Cell Adhesion Molecule - metabolism ; Female ; Flow cytometry ; Immunosuppression ; Internal Medicine ; Laboratory Medicine ; Lung cancer ; Lung carcinoma ; Lung transplantation ; Lymphocytes T ; Metastases ; Mice, Inbred C57BL ; Pathology ; PD-1 protein ; PD-L1 protein ; Plant Extracts - pharmacology ; Plant Roots - chemistry ; Rats ; Rodents ; Tumor Burden ; Tumor cells ; Xenograft Model Antitumor Assays</subject><ispartof>Bulletin of experimental biology and medicine, 2017-11, Vol.164 (1), p.102-105</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2017</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-f432eed60c7d923d2faabe59258b540c90ff3d025c6993afad355813a658fab93</citedby><cites>FETCH-LOGICAL-c372t-f432eed60c7d923d2faabe59258b540c90ff3d025c6993afad355813a658fab93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-017-3934-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-017-3934-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29124538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lopatina, K. A.</creatorcontrib><creatorcontrib>Safonova, E. A.</creatorcontrib><creatorcontrib>Nevskaya, K. V.</creatorcontrib><creatorcontrib>Stakheeva, M. N.</creatorcontrib><creatorcontrib>Gur’ev, A. M.</creatorcontrib><creatorcontrib>Zueva, E. P.</creatorcontrib><creatorcontrib>Razina, T. G.</creatorcontrib><creatorcontrib>Amosova, E. N.</creatorcontrib><creatorcontrib>Krylov, S. G.</creatorcontrib><creatorcontrib>Belousov, M. V.</creatorcontrib><title>Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Tumor cells can maintain their growth via immunosuppression and escape from host antitumor immunity by controlling the PD-1/PD-L1 system. Expression of PD-L1 (CD274) is an inhibitory signal for T cells, while the increase in CD326 expression in the tumor tissue correlates with metastasis development. The experimental preparation on the basis of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan from
Acorus calamus L.
produces an antitumor effect: it reduces tumor node size and the number and area of metastases after transplantation of Lewis lung carcinoma. Using flow cytometry, we demonstrated a decrease in the population of tumor cells expressing surface CD274 (PD-L1) and CD326 antigens after 20-day course of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan.</description><subject>Acorus - chemistry</subject><subject>Acorus calamus</subject><subject>Animals</subject><subject>Antigens</subject><subject>Antineoplastic Agents, Phytogenic - administration & dosage</subject><subject>Antitumor activity</subject><subject>B7-H1 Antigen - genetics</subject><subject>B7-H1 Antigen - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Carcinoma, Lewis Lung - drug therapy</subject><subject>Carcinoma, Lewis Lung - metabolism</subject><subject>Carcinoma, Lewis Lung - pathology</subject><subject>Cell Biology</subject><subject>Cell Line, Tumor</subject><subject>Epithelial Cell Adhesion Molecule - genetics</subject><subject>Epithelial Cell Adhesion Molecule - metabolism</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Immunosuppression</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Lung cancer</subject><subject>Lung carcinoma</subject><subject>Lung transplantation</subject><subject>Lymphocytes T</subject><subject>Metastases</subject><subject>Mice, Inbred C57BL</subject><subject>Pathology</subject><subject>PD-1 protein</subject><subject>PD-L1 protein</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots - chemistry</subject><subject>Rats</subject><subject>Rodents</subject><subject>Tumor Burden</subject><subject>Tumor cells</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1PGzEQhi1UVFLoD-BSWeqllw3-WO_ax2iblkpBcICz5fXa6aJdO9hZ0fx7JkqgEhIHa2zNM--M50XokpI5JaS-ypQIWhcEDle8LMoTNKOi5oVkjH5CMwJQUUopz9CXnB_3T1LRz-iMKcpKweUMhaX3zm5x9HhhY5oytmYwI8TVHN_FYZeNtX9N6juHY8DNT1aX2IQObpxVePlvk1zOPaTaHV655x4Kp7DGjUm2D3E0uHHDkHEf8E1v3QU69WbI7usxnqOHX8v75rpY3f7-0yxWheU12xa-5My5riK27hTjHfPGtE4oJmQrSmIV8Z53hAlbKcWNNx0XQlJuKiG9aRU_Rz8OupsUnyaXt3rss4VJTHBxypqqisNPoBmg39-hj3FKAabTDBYGYM0lUPRA2RRzTs7rTepHk3aaEr03Qx_M0GCG3puhS6j5dlSe2tF1bxWv2weAHYAMqbB26X_rj1VfAL9ikas</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Lopatina, K. 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Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice</title><author>Lopatina, K. A. ; Safonova, E. A. ; Nevskaya, K. V. ; Stakheeva, M. N. ; Gur’ev, A. M. ; Zueva, E. P. ; Razina, T. G. ; Amosova, E. N. ; Krylov, S. G. ; Belousov, M. 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A.</au><au>Safonova, E. A.</au><au>Nevskaya, K. V.</au><au>Stakheeva, M. N.</au><au>Gur’ev, A. M.</au><au>Zueva, E. P.</au><au>Razina, T. G.</au><au>Amosova, E. N.</au><au>Krylov, S. G.</au><au>Belousov, M. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>164</volume><issue>1</issue><spage>102</spage><epage>105</epage><pages>102-105</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>Tumor cells can maintain their growth via immunosuppression and escape from host antitumor immunity by controlling the PD-1/PD-L1 system. Expression of PD-L1 (CD274) is an inhibitory signal for T cells, while the increase in CD326 expression in the tumor tissue correlates with metastasis development. The experimental preparation on the basis of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan from
Acorus calamus L.
produces an antitumor effect: it reduces tumor node size and the number and area of metastases after transplantation of Lewis lung carcinoma. Using flow cytometry, we demonstrated a decrease in the population of tumor cells expressing surface CD274 (PD-L1) and CD326 antigens after 20-day course of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29124538</pmid><doi>10.1007/s10517-017-3934-4</doi><tpages>4</tpages></addata></record> |
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| subjects | Acorus - chemistry Acorus calamus Animals Antigens Antineoplastic Agents, Phytogenic - administration & dosage Antitumor activity B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Biomedical and Life Sciences Biomedicine Carcinoma, Lewis Lung - drug therapy Carcinoma, Lewis Lung - metabolism Carcinoma, Lewis Lung - pathology Cell Biology Cell Line, Tumor Epithelial Cell Adhesion Molecule - genetics Epithelial Cell Adhesion Molecule - metabolism Female Flow cytometry Immunosuppression Internal Medicine Laboratory Medicine Lung cancer Lung carcinoma Lung transplantation Lymphocytes T Metastases Mice, Inbred C57BL Pathology PD-1 protein PD-L1 protein Plant Extracts - pharmacology Plant Roots - chemistry Rats Rodents Tumor Burden Tumor cells Xenograft Model Antitumor Assays |
| title | Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice |
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