Treatment of Traumatic Brain Injury with Vepoloxamer (Purified Poloxamer 188)

Vepoloxamer is an amphipathic polymer that has shown potent hemorrheologic, cytoprotective, and anti-inflammatory effects in both pre-clinical and clinical studies. This study was designed to investigate the therapeutic effects of vepoloxamer on sensorimotor and cognitive functional recovery in rats...

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Veröffentlicht in:	Journal of neurotrauma 2018-02, Vol.35 (4), p.661-670
Hauptverfasser:	Zhang, Yanlu, Chopp, Michael, Emanuele, Martin, Zhang, Li, Zhang, Zheng Gang, Lu, Mei, Zhang, Talan, Mahmood, Asim, Xiong, Ye
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cognition Animals Apoptosis Brain Injuries, Traumatic - pathology Brain research Cell activation Cognitive ability Corpus callosum Cortex Epidemiology Gliosis Head injuries Hemorrhage Inflammation Intravenous administration Macrophages Male Microglia Neurology Neuroprotection Neuroprotective Agents - pharmacology Neurosurgery Poloxamer - pharmacology Polyethylene Rats Rats, Wistar Recovery of function Recovery of Function - drug effects Rodents Sensorimotor system Spatial discrimination learning Traumatic brain injury
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