Fluorescence image-guided neurosurgery
Surgery plays an important role in the management of high-grade gliomas (HGG) and imparts significant tumor-free and overall survival advantages. However HGG margins are often invisible, making their gross total resection (GTR) a difficult task. Hence intraoperative technology such as intraoperative...
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| Veröffentlicht in: | Future oncology (London, England) England), 2017-11, Vol.13 (26), p.2341-2348 |
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| creator | Kaneko, Sadao Eljamel, Muftah S |
| description | Surgery plays an important role in the management of high-grade gliomas (HGG) and imparts significant tumor-free and overall survival advantages. However HGG margins are often invisible, making their gross total resection (GTR) a difficult task. Hence intraoperative technology such as intraoperative fluorescence was a revolutionary discovery. A critical literature review revealed fluorescence improved the GTR of HGG from 36% using standard surgery to 74.5 and 84.4% using aminolevulinic acid (ALA) or fluorescein (FLCN), respectively. The differences between ALA-fluorescence image-guided neurosurgery (FIGS) and FLCN-FIGS in HGG were not statistically significant. However, the cost per quality added life years was US$16,218 and US$3181 for ALA-FIGS and FLCN-FIGS, respectively. Therefore, FIGS provided a reliable intraoperative tumor marker. Both ALA- and FLCN-FIGS significantly improved GTR and were cost-effective. |
| doi_str_mv | 10.2217/fon-2017-0194 |
| format | Article |
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However HGG margins are often invisible, making their gross total resection (GTR) a difficult task. Hence intraoperative technology such as intraoperative fluorescence was a revolutionary discovery. A critical literature review revealed fluorescence improved the GTR of HGG from 36% using standard surgery to 74.5 and 84.4% using aminolevulinic acid (ALA) or fluorescein (FLCN), respectively. The differences between ALA-fluorescence image-guided neurosurgery (FIGS) and FLCN-FIGS in HGG were not statistically significant. However, the cost per quality added life years was US$16,218 and US$3181 for ALA-FIGS and FLCN-FIGS, respectively. Therefore, FIGS provided a reliable intraoperative tumor marker. Both ALA- and FLCN-FIGS significantly improved GTR and were cost-effective.</description><identifier>ISSN: 1479-6694</identifier><identifier>EISSN: 1744-8301</identifier><identifier>DOI: 10.2217/fon-2017-0194</identifier><identifier>PMID: 29121788</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Acids ; ALA ; Brain cancer ; Brain Neoplasms - diagnostic imaging ; Brain Neoplasms - pathology ; Brain Neoplasms - surgery ; Clinical trials ; Enzymes ; fluorescein ; fluorescence ; Glioma ; Glioma - diagnostic imaging ; Glioma - pathology ; Glioma - surgery ; Humans ; image guidance ; meningioma ; Metabolism ; Neurosurgery ; Optical Imaging - methods ; Studies ; Surgeons ; Surgery ; Surgery, Computer-Assisted - methods ; surgical resection ; Treatment Outcome ; Tumors</subject><ispartof>Future oncology (London, England), 2017-11, Vol.13 (26), p.2341-2348</ispartof><rights>2017 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Nov 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-7f5d13a7d5da7b504c5757d7cda5de32b6ab1acf9c88c99f32077920490cd953</citedby><cites>FETCH-LOGICAL-c371t-7f5d13a7d5da7b504c5757d7cda5de32b6ab1acf9c88c99f32077920490cd953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29121788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaneko, Sadao</creatorcontrib><creatorcontrib>Eljamel, Muftah S</creatorcontrib><title>Fluorescence image-guided neurosurgery</title><title>Future oncology (London, England)</title><addtitle>Future Oncol</addtitle><description>Surgery plays an important role in the management of high-grade gliomas (HGG) and imparts significant tumor-free and overall survival advantages. However HGG margins are often invisible, making their gross total resection (GTR) a difficult task. Hence intraoperative technology such as intraoperative fluorescence was a revolutionary discovery. A critical literature review revealed fluorescence improved the GTR of HGG from 36% using standard surgery to 74.5 and 84.4% using aminolevulinic acid (ALA) or fluorescein (FLCN), respectively. The differences between ALA-fluorescence image-guided neurosurgery (FIGS) and FLCN-FIGS in HGG were not statistically significant. However, the cost per quality added life years was US$16,218 and US$3181 for ALA-FIGS and FLCN-FIGS, respectively. Therefore, FIGS provided a reliable intraoperative tumor marker. Both ALA- and FLCN-FIGS significantly improved GTR and were cost-effective.</description><subject>Acids</subject><subject>ALA</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - surgery</subject><subject>Clinical trials</subject><subject>Enzymes</subject><subject>fluorescein</subject><subject>fluorescence</subject><subject>Glioma</subject><subject>Glioma - diagnostic imaging</subject><subject>Glioma - pathology</subject><subject>Glioma - surgery</subject><subject>Humans</subject><subject>image guidance</subject><subject>meningioma</subject><subject>Metabolism</subject><subject>Neurosurgery</subject><subject>Optical Imaging - methods</subject><subject>Studies</subject><subject>Surgeons</subject><subject>Surgery</subject><subject>Surgery, Computer-Assisted - methods</subject><subject>surgical resection</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>1479-6694</issn><issn>1744-8301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE1LAzEQhoMotlaPXqUgiJdoPnc2RylWhYKX3kM2yZYt292aNIf-e7Ns9SB4mhl45mXmQeiWkifGKDzXfYcZoYAJVeIMTSkIgUtO6HnuBShcFEpM0FWMW0IEcEku0YQpmnfLcooelm3qg4_Wd9bPm53ZeLxJjfNu3vkU-pjCxofjNbqoTRv9zanO0Hr5ul6849Xn28fiZYUtB3rAUEtHuQEnnYFKEmElSHBgnZHOc1YVpqLG1sqWpVWq5owAKEaEItYpyWfocYzdh_4r-XjQuyaf1ram832KmqqCM2AgB_T-D7rtU-jycZplQBElKc0UHimbX4nB13of8pPhqCnRgz-d_enBnx78Zf7ulJqqnXe_9I-wDKgRqNMhDd6aQZwep7zR2Kbz_4R_A82IfYM</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Kaneko, Sadao</creator><creator>Eljamel, Muftah S</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20171101</creationdate><title>Fluorescence image-guided neurosurgery</title><author>Kaneko, Sadao ; Eljamel, Muftah S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-7f5d13a7d5da7b504c5757d7cda5de32b6ab1acf9c88c99f32077920490cd953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acids</topic><topic>ALA</topic><topic>Brain cancer</topic><topic>Brain Neoplasms - diagnostic imaging</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - surgery</topic><topic>Clinical trials</topic><topic>Enzymes</topic><topic>fluorescein</topic><topic>fluorescence</topic><topic>Glioma</topic><topic>Glioma - diagnostic imaging</topic><topic>Glioma - pathology</topic><topic>Glioma - surgery</topic><topic>Humans</topic><topic>image guidance</topic><topic>meningioma</topic><topic>Metabolism</topic><topic>Neurosurgery</topic><topic>Optical Imaging - methods</topic><topic>Studies</topic><topic>Surgeons</topic><topic>Surgery</topic><topic>Surgery, Computer-Assisted - methods</topic><topic>surgical resection</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaneko, Sadao</creatorcontrib><creatorcontrib>Eljamel, Muftah S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Future oncology (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaneko, Sadao</au><au>Eljamel, Muftah S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluorescence image-guided neurosurgery</atitle><jtitle>Future oncology (London, England)</jtitle><addtitle>Future Oncol</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>13</volume><issue>26</issue><spage>2341</spage><epage>2348</epage><pages>2341-2348</pages><issn>1479-6694</issn><eissn>1744-8301</eissn><abstract>Surgery plays an important role in the management of high-grade gliomas (HGG) and imparts significant tumor-free and overall survival advantages. However HGG margins are often invisible, making their gross total resection (GTR) a difficult task. Hence intraoperative technology such as intraoperative fluorescence was a revolutionary discovery. A critical literature review revealed fluorescence improved the GTR of HGG from 36% using standard surgery to 74.5 and 84.4% using aminolevulinic acid (ALA) or fluorescein (FLCN), respectively. The differences between ALA-fluorescence image-guided neurosurgery (FIGS) and FLCN-FIGS in HGG were not statistically significant. However, the cost per quality added life years was US$16,218 and US$3181 for ALA-FIGS and FLCN-FIGS, respectively. Therefore, FIGS provided a reliable intraoperative tumor marker. Both ALA- and FLCN-FIGS significantly improved GTR and were cost-effective.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>29121788</pmid><doi>10.2217/fon-2017-0194</doi><tpages>8</tpages></addata></record> |
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| subjects | Acids ALA Brain cancer Brain Neoplasms - diagnostic imaging Brain Neoplasms - pathology Brain Neoplasms - surgery Clinical trials Enzymes fluorescein fluorescence Glioma Glioma - diagnostic imaging Glioma - pathology Glioma - surgery Humans image guidance meningioma Metabolism Neurosurgery Optical Imaging - methods Studies Surgeons Surgery Surgery, Computer-Assisted - methods surgical resection Treatment Outcome Tumors |
| title | Fluorescence image-guided neurosurgery |
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