Elevated lung clearance index in infants with cystic fibrosis shortly after birth
It is not known at what age lung function impairment may arise in children with cystic fibrosis (CF). We assessed lung function shortly after birth in infants with CF diagnosed by newborn screening.We performed infant lung function measurements in a prospective cohort of infants with CF and healthy...
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| Veröffentlicht in: | The European respiratory journal 2017-11, Vol.50 (5), p.1700580-1700580 |
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| creator | Kieninger, Elisabeth Yammine, Sophie Korten, Insa Anagnostopoulou, Pinelopi Singer, Florian Frey, Urs Mornand, Anne Zanolari, Maura Rochat, Isabelle Trachsel, Daniel Mueller-Suter, Dominik Moeller, Alexander Casaulta, Carmen Latzin, Philipp |
| description | It is not known at what age lung function impairment may arise in children with cystic fibrosis (CF). We assessed lung function shortly after birth in infants with CF diagnosed by newborn screening.We performed infant lung function measurements in a prospective cohort of infants with CF and healthy controls. We assessed lung clearance index (LCI), functional residual capacity (FRC) and tidal breathing parameters. The primary outcome was prevalence and severity of abnormal lung function (±1.64 z-scores) in CF.We enrolled 53 infants with CF (mean age 7.8 weeks) and 57 controls (mean age 5.2 weeks). Compared to controls, LCI and FRC were elevated (mean difference 0.30, 95% CI 0.02-0.60; p=0.034 and 14.5 mL, 95% CI 7.7-21.3 mL; p |
| doi_str_mv | 10.1183/13993003.00580-2017 |
| format | Article |
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We assessed lung function shortly after birth in infants with CF diagnosed by newborn screening.We performed infant lung function measurements in a prospective cohort of infants with CF and healthy controls. We assessed lung clearance index (LCI), functional residual capacity (FRC) and tidal breathing parameters. The primary outcome was prevalence and severity of abnormal lung function (±1.64 z-scores) in CF.We enrolled 53 infants with CF (mean age 7.8 weeks) and 57 controls (mean age 5.2 weeks). Compared to controls, LCI and FRC were elevated (mean difference 0.30, 95% CI 0.02-0.60; p=0.034 and 14.5 mL, 95% CI 7.7-21.3 mL; p<0.001, respectively), while ratio of time to peak tidal expiratory flow to expiratory time was decreased in infants with CF. In 22 (41.5%) infants with CF, either LCI or FRC exceeded 1.64 z-scores; three infants had both elevated LCI and FRC.Shortly after birth, abnormal lung function is prevalent in CF infants. Ventilation inhomogeneity or hyperinflation may serve as noninvasive markers to monitor CF lung disease and specific treatment effects, and could thus be used as outcome parameters for future intervention studies in this age group.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/13993003.00580-2017</identifier><identifier>PMID: 29122915</identifier><language>eng</language><publisher>England: European Respiratory Society Journals Ltd</publisher><subject>Age ; Birth ; Breath Tests ; Case-Control Studies ; Children ; Cross-Sectional Studies ; Cystic fibrosis ; Cystic Fibrosis - diagnosis ; Cystic Fibrosis - physiopathology ; Female ; Functional Residual Capacity ; Humans ; Infant ; Infant, Newborn ; Infants ; Lung - physiopathology ; Lung diseases ; Male ; Medical screening ; Multivariate Analysis ; Neonatal Screening ; Prospective Studies ; Regression Analysis ; Respiratory function ; Switzerland</subject><ispartof>The European respiratory journal, 2017-11, Vol.50 (5), p.1700580-1700580</ispartof><rights>Copyright ©ERS 2017.</rights><rights>Copyright European Respiratory Society Journals Ltd. Nov 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-a4e6c2c156d4f99b0110c655d341ba689cc4d08f07bfd831162352fd7fe040643</citedby><cites>FETCH-LOGICAL-c378t-a4e6c2c156d4f99b0110c655d341ba689cc4d08f07bfd831162352fd7fe040643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29122915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kieninger, Elisabeth</creatorcontrib><creatorcontrib>Yammine, Sophie</creatorcontrib><creatorcontrib>Korten, Insa</creatorcontrib><creatorcontrib>Anagnostopoulou, Pinelopi</creatorcontrib><creatorcontrib>Singer, Florian</creatorcontrib><creatorcontrib>Frey, Urs</creatorcontrib><creatorcontrib>Mornand, Anne</creatorcontrib><creatorcontrib>Zanolari, Maura</creatorcontrib><creatorcontrib>Rochat, Isabelle</creatorcontrib><creatorcontrib>Trachsel, Daniel</creatorcontrib><creatorcontrib>Mueller-Suter, Dominik</creatorcontrib><creatorcontrib>Moeller, Alexander</creatorcontrib><creatorcontrib>Casaulta, Carmen</creatorcontrib><creatorcontrib>Latzin, Philipp</creatorcontrib><creatorcontrib>and the SCILD</creatorcontrib><creatorcontrib>and BILD study groups</creatorcontrib><title>Elevated lung clearance index in infants with cystic fibrosis shortly after birth</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>It is not known at what age lung function impairment may arise in children with cystic fibrosis (CF). We assessed lung function shortly after birth in infants with CF diagnosed by newborn screening.We performed infant lung function measurements in a prospective cohort of infants with CF and healthy controls. We assessed lung clearance index (LCI), functional residual capacity (FRC) and tidal breathing parameters. The primary outcome was prevalence and severity of abnormal lung function (±1.64 z-scores) in CF.We enrolled 53 infants with CF (mean age 7.8 weeks) and 57 controls (mean age 5.2 weeks). Compared to controls, LCI and FRC were elevated (mean difference 0.30, 95% CI 0.02-0.60; p=0.034 and 14.5 mL, 95% CI 7.7-21.3 mL; p<0.001, respectively), while ratio of time to peak tidal expiratory flow to expiratory time was decreased in infants with CF. In 22 (41.5%) infants with CF, either LCI or FRC exceeded 1.64 z-scores; three infants had both elevated LCI and FRC.Shortly after birth, abnormal lung function is prevalent in CF infants. Ventilation inhomogeneity or hyperinflation may serve as noninvasive markers to monitor CF lung disease and specific treatment effects, and could thus be used as outcome parameters for future intervention studies in this age group.</description><subject>Age</subject><subject>Birth</subject><subject>Breath Tests</subject><subject>Case-Control Studies</subject><subject>Children</subject><subject>Cross-Sectional Studies</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - diagnosis</subject><subject>Cystic Fibrosis - physiopathology</subject><subject>Female</subject><subject>Functional Residual Capacity</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Lung - physiopathology</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medical screening</subject><subject>Multivariate Analysis</subject><subject>Neonatal Screening</subject><subject>Prospective Studies</subject><subject>Regression Analysis</subject><subject>Respiratory function</subject><subject>Switzerland</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkNtKAzEQhoMotlafQJCAN95sndnsIbmUUg9QEEGvl2w2sVu2uzXJqn17s7b1QpgDDP_8zHyEXCJMETm7RSYEA2BTgJRDFAPmR2Q8TKNhfEzGIIBFKFg2ImfOrQAwSxieklEsMA6ZjsnLvNGf0uuKNn37TlWjpZWt0rRuK_0daggjW-_oV-2XVG2drxU1dWk7Vzvqlp31zZZK47WlZW398pycGNk4fbHvE_J2P3-dPUaL54en2d0iUiznPpKJzlSsMM2qxAhRAiKoLE0rlmApMy6USirgBvLSVJwhZjFLY1PlRkMC4Y8Judn5bmz30Wvni3XtlG4a2equdwWKjMU5Chyk1_-kq663bbguqHjCeJwEYBPCdioVfnNWm2Jj67W02wKhGIgXB-LFL_FiIB62rvbefbnW1d_OATH7AV9Ueks</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Kieninger, Elisabeth</creator><creator>Yammine, Sophie</creator><creator>Korten, Insa</creator><creator>Anagnostopoulou, Pinelopi</creator><creator>Singer, Florian</creator><creator>Frey, Urs</creator><creator>Mornand, Anne</creator><creator>Zanolari, Maura</creator><creator>Rochat, Isabelle</creator><creator>Trachsel, Daniel</creator><creator>Mueller-Suter, Dominik</creator><creator>Moeller, Alexander</creator><creator>Casaulta, Carmen</creator><creator>Latzin, Philipp</creator><general>European Respiratory Society Journals Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201711</creationdate><title>Elevated lung clearance index in infants with cystic fibrosis shortly after birth</title><author>Kieninger, Elisabeth ; Yammine, Sophie ; Korten, Insa ; Anagnostopoulou, Pinelopi ; Singer, Florian ; Frey, Urs ; Mornand, Anne ; Zanolari, Maura ; Rochat, Isabelle ; Trachsel, Daniel ; Mueller-Suter, Dominik ; Moeller, Alexander ; Casaulta, Carmen ; Latzin, Philipp</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-a4e6c2c156d4f99b0110c655d341ba689cc4d08f07bfd831162352fd7fe040643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Birth</topic><topic>Breath Tests</topic><topic>Case-Control Studies</topic><topic>Children</topic><topic>Cross-Sectional Studies</topic><topic>Cystic fibrosis</topic><topic>Cystic Fibrosis - diagnosis</topic><topic>Cystic Fibrosis - physiopathology</topic><topic>Female</topic><topic>Functional Residual Capacity</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Lung - physiopathology</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Medical screening</topic><topic>Multivariate Analysis</topic><topic>Neonatal Screening</topic><topic>Prospective Studies</topic><topic>Regression Analysis</topic><topic>Respiratory function</topic><topic>Switzerland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kieninger, Elisabeth</creatorcontrib><creatorcontrib>Yammine, Sophie</creatorcontrib><creatorcontrib>Korten, Insa</creatorcontrib><creatorcontrib>Anagnostopoulou, Pinelopi</creatorcontrib><creatorcontrib>Singer, Florian</creatorcontrib><creatorcontrib>Frey, Urs</creatorcontrib><creatorcontrib>Mornand, Anne</creatorcontrib><creatorcontrib>Zanolari, Maura</creatorcontrib><creatorcontrib>Rochat, Isabelle</creatorcontrib><creatorcontrib>Trachsel, Daniel</creatorcontrib><creatorcontrib>Mueller-Suter, Dominik</creatorcontrib><creatorcontrib>Moeller, Alexander</creatorcontrib><creatorcontrib>Casaulta, Carmen</creatorcontrib><creatorcontrib>Latzin, Philipp</creatorcontrib><creatorcontrib>and the SCILD</creatorcontrib><creatorcontrib>and BILD study groups</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kieninger, Elisabeth</au><au>Yammine, Sophie</au><au>Korten, Insa</au><au>Anagnostopoulou, Pinelopi</au><au>Singer, Florian</au><au>Frey, Urs</au><au>Mornand, Anne</au><au>Zanolari, Maura</au><au>Rochat, Isabelle</au><au>Trachsel, Daniel</au><au>Mueller-Suter, Dominik</au><au>Moeller, Alexander</au><au>Casaulta, Carmen</au><au>Latzin, Philipp</au><aucorp>and the SCILD</aucorp><aucorp>and BILD study groups</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated lung clearance index in infants with cystic fibrosis shortly after birth</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2017-11</date><risdate>2017</risdate><volume>50</volume><issue>5</issue><spage>1700580</spage><epage>1700580</epage><pages>1700580-1700580</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>It is not known at what age lung function impairment may arise in children with cystic fibrosis (CF). We assessed lung function shortly after birth in infants with CF diagnosed by newborn screening.We performed infant lung function measurements in a prospective cohort of infants with CF and healthy controls. We assessed lung clearance index (LCI), functional residual capacity (FRC) and tidal breathing parameters. The primary outcome was prevalence and severity of abnormal lung function (±1.64 z-scores) in CF.We enrolled 53 infants with CF (mean age 7.8 weeks) and 57 controls (mean age 5.2 weeks). Compared to controls, LCI and FRC were elevated (mean difference 0.30, 95% CI 0.02-0.60; p=0.034 and 14.5 mL, 95% CI 7.7-21.3 mL; p<0.001, respectively), while ratio of time to peak tidal expiratory flow to expiratory time was decreased in infants with CF. In 22 (41.5%) infants with CF, either LCI or FRC exceeded 1.64 z-scores; three infants had both elevated LCI and FRC.Shortly after birth, abnormal lung function is prevalent in CF infants. Ventilation inhomogeneity or hyperinflation may serve as noninvasive markers to monitor CF lung disease and specific treatment effects, and could thus be used as outcome parameters for future intervention studies in this age group.</abstract><cop>England</cop><pub>European Respiratory Society Journals Ltd</pub><pmid>29122915</pmid><doi>10.1183/13993003.00580-2017</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0903-1936 |
| ispartof | The European respiratory journal, 2017-11, Vol.50 (5), p.1700580-1700580 |
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| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Age Birth Breath Tests Case-Control Studies Children Cross-Sectional Studies Cystic fibrosis Cystic Fibrosis - diagnosis Cystic Fibrosis - physiopathology Female Functional Residual Capacity Humans Infant Infant, Newborn Infants Lung - physiopathology Lung diseases Male Medical screening Multivariate Analysis Neonatal Screening Prospective Studies Regression Analysis Respiratory function Switzerland |
| title | Elevated lung clearance index in infants with cystic fibrosis shortly after birth |
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