Effects of acupuncture on the anxiety-like behavior induced by withdrawal from chronic morphine use
•Open arms time in the elevated plus maze was reduced by withdrawal from chronic morphine use.•Acupuncture at the specific acupoint HT7, but not at control acupoint LI5, increased open arms time.•Effects of Acupuncture were blocked by GABAA receptor antagonist.•Acupuncture inhibits the anxiety-like...
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| Veröffentlicht in: | Neuroscience letters 2018-01, Vol.664, p.38-42 |
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| creator | Kim, Dong Hyeon Kim, Nam Jun Zhao, Rong Jie Kim, Da Hye Yang, Chae Ha Kim, Hee Young Gwak, Young S. Jang, Eun Young Kim, Jae Soo Lee, Yun Kyu Lee, Hyun Jong Lim, Sung Chul Lee, Bong Hyo |
| description | •Open arms time in the elevated plus maze was reduced by withdrawal from chronic morphine use.•Acupuncture at the specific acupoint HT7, but not at control acupoint LI5, increased open arms time.•Effects of Acupuncture were blocked by GABAA receptor antagonist.•Acupuncture inhibits the anxiety-like behavior induced by withdrawal from chronic morphine, at least in part, via GABAA receptor pathway.
In the previous studies, it has been demonstrated that acupuncture treatment was effective on the suppression of withdrawal signs as well as self-administration behavior induced by morphine. Based on, the present study has investigated whether acupuncture could attenuate the anxiety-like behavior induced by withdrawal from chronic morphine treatment.
Male Sprague-Dawley rats weighing 270–300g were treated saline or morphine hydrochloride (10mg/kg, s.c.) for 2 weeks. Following abstinence of 5days in home cage, rats were subjected to the measurement of anxiety-like behavior in the elevated plus maze. Bicuculline (1mg/kg, i.p.) and SCH 50911 (2mg/kg, i.p.) were used to investigate the possible mechanism of acupuncture effects focusing on the GABA receptors system.
Acupuncture at HT7 increased the time spent in open arms significantly. Also, these effects of acupuncture at HT7 were blocked by GABAA receptor antagonist.
Results of the present study suggest that acupuncture at HT7 can attenuate anxiety-like behavior induced by withdrawal from chronic morphine treatment through the mediation of GABAA receptor system. |
| doi_str_mv | 10.1016/j.neulet.2017.11.008 |
| format | Article |
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In the previous studies, it has been demonstrated that acupuncture treatment was effective on the suppression of withdrawal signs as well as self-administration behavior induced by morphine. Based on, the present study has investigated whether acupuncture could attenuate the anxiety-like behavior induced by withdrawal from chronic morphine treatment.
Male Sprague-Dawley rats weighing 270–300g were treated saline or morphine hydrochloride (10mg/kg, s.c.) for 2 weeks. Following abstinence of 5days in home cage, rats were subjected to the measurement of anxiety-like behavior in the elevated plus maze. Bicuculline (1mg/kg, i.p.) and SCH 50911 (2mg/kg, i.p.) were used to investigate the possible mechanism of acupuncture effects focusing on the GABA receptors system.
Acupuncture at HT7 increased the time spent in open arms significantly. Also, these effects of acupuncture at HT7 were blocked by GABAA receptor antagonist.
Results of the present study suggest that acupuncture at HT7 can attenuate anxiety-like behavior induced by withdrawal from chronic morphine treatment through the mediation of GABAA receptor system.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2017.11.008</identifier><identifier>PMID: 29126776</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Acupuncture ; Acupuncture Therapy - methods ; Animals ; Anxiety ; Anxiety - psychology ; Anxiety - therapy ; GABA ; GABA-A Receptor Antagonists - pharmacology ; HT7 ; Male ; Maze Learning - drug effects ; Maze Learning - physiology ; Morphine ; Morphine - administration & dosage ; Morphine - adverse effects ; Morphine Dependence - psychology ; Morphine Dependence - therapy ; Rats ; Rats, Sprague-Dawley ; Receptors, GABA-A - physiology ; Substance Withdrawal Syndrome - psychology ; Substance Withdrawal Syndrome - therapy ; Treatment Outcome</subject><ispartof>Neuroscience letters, 2018-01, Vol.664, p.38-42</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-4d8a562087be3b032ccddb0ca18e96aa511e7bd7f31eab6965ec946bd77b594d3</citedby><cites>FETCH-LOGICAL-c428t-4d8a562087be3b032ccddb0ca18e96aa511e7bd7f31eab6965ec946bd77b594d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2017.11.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29126776$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Dong Hyeon</creatorcontrib><creatorcontrib>Kim, Nam Jun</creatorcontrib><creatorcontrib>Zhao, Rong Jie</creatorcontrib><creatorcontrib>Kim, Da Hye</creatorcontrib><creatorcontrib>Yang, Chae Ha</creatorcontrib><creatorcontrib>Kim, Hee Young</creatorcontrib><creatorcontrib>Gwak, Young S.</creatorcontrib><creatorcontrib>Jang, Eun Young</creatorcontrib><creatorcontrib>Kim, Jae Soo</creatorcontrib><creatorcontrib>Lee, Yun Kyu</creatorcontrib><creatorcontrib>Lee, Hyun Jong</creatorcontrib><creatorcontrib>Lim, Sung Chul</creatorcontrib><creatorcontrib>Lee, Bong Hyo</creatorcontrib><title>Effects of acupuncture on the anxiety-like behavior induced by withdrawal from chronic morphine use</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>•Open arms time in the elevated plus maze was reduced by withdrawal from chronic morphine use.•Acupuncture at the specific acupoint HT7, but not at control acupoint LI5, increased open arms time.•Effects of Acupuncture were blocked by GABAA receptor antagonist.•Acupuncture inhibits the anxiety-like behavior induced by withdrawal from chronic morphine, at least in part, via GABAA receptor pathway.
In the previous studies, it has been demonstrated that acupuncture treatment was effective on the suppression of withdrawal signs as well as self-administration behavior induced by morphine. Based on, the present study has investigated whether acupuncture could attenuate the anxiety-like behavior induced by withdrawal from chronic morphine treatment.
Male Sprague-Dawley rats weighing 270–300g were treated saline or morphine hydrochloride (10mg/kg, s.c.) for 2 weeks. Following abstinence of 5days in home cage, rats were subjected to the measurement of anxiety-like behavior in the elevated plus maze. Bicuculline (1mg/kg, i.p.) and SCH 50911 (2mg/kg, i.p.) were used to investigate the possible mechanism of acupuncture effects focusing on the GABA receptors system.
Acupuncture at HT7 increased the time spent in open arms significantly. Also, these effects of acupuncture at HT7 were blocked by GABAA receptor antagonist.
Results of the present study suggest that acupuncture at HT7 can attenuate anxiety-like behavior induced by withdrawal from chronic morphine treatment through the mediation of GABAA receptor system.</description><subject>Acupuncture</subject><subject>Acupuncture Therapy - methods</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Anxiety - psychology</subject><subject>Anxiety - therapy</subject><subject>GABA</subject><subject>GABA-A Receptor Antagonists - pharmacology</subject><subject>HT7</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Maze Learning - physiology</subject><subject>Morphine</subject><subject>Morphine - administration & dosage</subject><subject>Morphine - adverse effects</subject><subject>Morphine Dependence - psychology</subject><subject>Morphine Dependence - therapy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, GABA-A - physiology</subject><subject>Substance Withdrawal Syndrome - psychology</subject><subject>Substance Withdrawal Syndrome - therapy</subject><subject>Treatment Outcome</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhq0K1G4__gFCPnJJ8DiJnVyQUFUoUiUucLb8MVG8JPZix23335NqC0dOI42ed17NQ8g7YDUwEB_3dcAy41pzBrIGqBnrz8gOeskrOUj-huxYw9qqGVp2QS5z3jPGOujac3LBB-BCSrEj9m4c0a6ZxpFqWw4l2LUkpDHQdUKqw7PH9VjN_hdSg5N-9DFRH1yx6Kg50ie_Ti7pJz3TMcWF2inF4C1dYjpMPiAtGa_J21HPGW9e5xX5-eXux-199fD967fbzw-VbXm_Vq3rdSc466XBxrCGW-ucYVZDj4PQugNAaZwcG0BtxCA6tEMrto003dC65op8ON09pPi7YF7V4rPFedYBY8kKBtFwCQLEhrYn1KaYc8JRHZJfdDoqYOpFr9qrk171olcBqE3vFnv_2lDMgu5f6K_PDfh0AnD789FjUtl6DJssnzbNykX__4Y_gdOPoA</recordid><startdate>20180118</startdate><enddate>20180118</enddate><creator>Kim, Dong Hyeon</creator><creator>Kim, Nam Jun</creator><creator>Zhao, Rong Jie</creator><creator>Kim, Da Hye</creator><creator>Yang, Chae Ha</creator><creator>Kim, Hee Young</creator><creator>Gwak, Young S.</creator><creator>Jang, Eun Young</creator><creator>Kim, Jae Soo</creator><creator>Lee, Yun Kyu</creator><creator>Lee, Hyun Jong</creator><creator>Lim, Sung Chul</creator><creator>Lee, Bong Hyo</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180118</creationdate><title>Effects of acupuncture on the anxiety-like behavior induced by withdrawal from chronic morphine use</title><author>Kim, Dong Hyeon ; Kim, Nam Jun ; Zhao, Rong Jie ; Kim, Da Hye ; Yang, Chae Ha ; Kim, Hee Young ; Gwak, Young S. ; Jang, Eun Young ; Kim, Jae Soo ; Lee, Yun Kyu ; Lee, Hyun Jong ; Lim, Sung Chul ; Lee, Bong Hyo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-4d8a562087be3b032ccddb0ca18e96aa511e7bd7f31eab6965ec946bd77b594d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acupuncture</topic><topic>Acupuncture Therapy - methods</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Anxiety - psychology</topic><topic>Anxiety - therapy</topic><topic>GABA</topic><topic>GABA-A Receptor Antagonists - pharmacology</topic><topic>HT7</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Maze Learning - physiology</topic><topic>Morphine</topic><topic>Morphine - administration & dosage</topic><topic>Morphine - adverse effects</topic><topic>Morphine Dependence - psychology</topic><topic>Morphine Dependence - therapy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, GABA-A - physiology</topic><topic>Substance Withdrawal Syndrome - psychology</topic><topic>Substance Withdrawal Syndrome - therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Dong Hyeon</creatorcontrib><creatorcontrib>Kim, Nam Jun</creatorcontrib><creatorcontrib>Zhao, Rong Jie</creatorcontrib><creatorcontrib>Kim, Da Hye</creatorcontrib><creatorcontrib>Yang, Chae Ha</creatorcontrib><creatorcontrib>Kim, Hee Young</creatorcontrib><creatorcontrib>Gwak, Young S.</creatorcontrib><creatorcontrib>Jang, Eun Young</creatorcontrib><creatorcontrib>Kim, Jae Soo</creatorcontrib><creatorcontrib>Lee, Yun Kyu</creatorcontrib><creatorcontrib>Lee, Hyun Jong</creatorcontrib><creatorcontrib>Lim, Sung Chul</creatorcontrib><creatorcontrib>Lee, Bong Hyo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Dong Hyeon</au><au>Kim, Nam Jun</au><au>Zhao, Rong Jie</au><au>Kim, Da Hye</au><au>Yang, Chae Ha</au><au>Kim, Hee Young</au><au>Gwak, Young S.</au><au>Jang, Eun Young</au><au>Kim, Jae Soo</au><au>Lee, Yun Kyu</au><au>Lee, Hyun Jong</au><au>Lim, Sung Chul</au><au>Lee, Bong Hyo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of acupuncture on the anxiety-like behavior induced by withdrawal from chronic morphine use</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2018-01-18</date><risdate>2018</risdate><volume>664</volume><spage>38</spage><epage>42</epage><pages>38-42</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>•Open arms time in the elevated plus maze was reduced by withdrawal from chronic morphine use.•Acupuncture at the specific acupoint HT7, but not at control acupoint LI5, increased open arms time.•Effects of Acupuncture were blocked by GABAA receptor antagonist.•Acupuncture inhibits the anxiety-like behavior induced by withdrawal from chronic morphine, at least in part, via GABAA receptor pathway.
In the previous studies, it has been demonstrated that acupuncture treatment was effective on the suppression of withdrawal signs as well as self-administration behavior induced by morphine. Based on, the present study has investigated whether acupuncture could attenuate the anxiety-like behavior induced by withdrawal from chronic morphine treatment.
Male Sprague-Dawley rats weighing 270–300g were treated saline or morphine hydrochloride (10mg/kg, s.c.) for 2 weeks. Following abstinence of 5days in home cage, rats were subjected to the measurement of anxiety-like behavior in the elevated plus maze. Bicuculline (1mg/kg, i.p.) and SCH 50911 (2mg/kg, i.p.) were used to investigate the possible mechanism of acupuncture effects focusing on the GABA receptors system.
Acupuncture at HT7 increased the time spent in open arms significantly. Also, these effects of acupuncture at HT7 were blocked by GABAA receptor antagonist.
Results of the present study suggest that acupuncture at HT7 can attenuate anxiety-like behavior induced by withdrawal from chronic morphine treatment through the mediation of GABAA receptor system.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>29126776</pmid><doi>10.1016/j.neulet.2017.11.008</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neuroscience letters, 2018-01, Vol.664, p.38-42 |
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| subjects | Acupuncture Acupuncture Therapy - methods Animals Anxiety Anxiety - psychology Anxiety - therapy GABA GABA-A Receptor Antagonists - pharmacology HT7 Male Maze Learning - drug effects Maze Learning - physiology Morphine Morphine - administration & dosage Morphine - adverse effects Morphine Dependence - psychology Morphine Dependence - therapy Rats Rats, Sprague-Dawley Receptors, GABA-A - physiology Substance Withdrawal Syndrome - psychology Substance Withdrawal Syndrome - therapy Treatment Outcome |
| title | Effects of acupuncture on the anxiety-like behavior induced by withdrawal from chronic morphine use |
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