Prognostic impact of RITA expression in patients with anal squamous cell carcinoma treated with chemoradiotherapy
RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notch signalling pathway and its deregulation is involved in the pathogenesis of several tumour entities. RITA’s impact on the response of anal squamous cell carcinoma (SCC) to anticancer treat...
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| Veröffentlicht in: | Radiotherapy and oncology 2018-02, Vol.126 (2), p.214-221 |
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| creator | Rödel, Franz Steinhäuser, Kerstin Kreis, Nina-Naomi Friemel, Alexandra Martin, Daniel Wieland, Ulrike Rave-Fränk, Margret Balermpas, Panagiotis Fokas, Emmanouil Louwen, Frank Rödel, Claus Yuan, Juping |
| description | RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notch signalling pathway and its deregulation is involved in the pathogenesis of several tumour entities. RITA’s impact on the response of anal squamous cell carcinoma (SCC) to anticancer treatment, however, remains elusive.
In our retrospective study immunohistochemical evaluation of RITA was performed on 140 pre-treatment specimens and was correlated with clinical and histopathologic characteristics and clinical endpoints cumulative incidence of local control (LC), distant recurrence (DC), disease-free survival (DFS) and overall survival (OS).
We observed significant inverse correlations between RITA expression and tumour grading, the levels of HPV-16 virus DNA load, CD8 (+) tumour infiltrating lymphocytes and programmed death protein (PD-1) immunostaining. In univariate analyses, elevated levels of RITA expression were predictive for decreased local control (p = 0.001), decreased distant control (p = 0.040), decreased disease free survival (p = 0.001) and overall survival (p |
| doi_str_mv | 10.1016/j.radonc.2017.10.028 |
| format | Article |
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In our retrospective study immunohistochemical evaluation of RITA was performed on 140 pre-treatment specimens and was correlated with clinical and histopathologic characteristics and clinical endpoints cumulative incidence of local control (LC), distant recurrence (DC), disease-free survival (DFS) and overall survival (OS).
We observed significant inverse correlations between RITA expression and tumour grading, the levels of HPV-16 virus DNA load, CD8 (+) tumour infiltrating lymphocytes and programmed death protein (PD-1) immunostaining. In univariate analyses, elevated levels of RITA expression were predictive for decreased local control (p = 0.001), decreased distant control (p = 0.040), decreased disease free survival (p = 0.001) and overall survival (p < 0.0001), whereas in multivariate analyses RITA expression remained significant for decreased local control (p = 0.009), disease free survival (p = 0.032) and overall survival (p = 0.012).
These data indicate that elevated levels of pretreatment RITA expression are correlated with unfavourable clinical outcome in anal carcinoma treated with concomitant chemoradiotherapy.</description><identifier>ISSN: 0167-8140</identifier><identifier>EISSN: 1879-0887</identifier><identifier>DOI: 10.1016/j.radonc.2017.10.028</identifier><identifier>PMID: 29122359</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Anal cancer ; Anus Neoplasms - drug therapy ; Anus Neoplasms - metabolism ; Anus Neoplasms - radiotherapy ; Anus Neoplasms - therapy ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - radiotherapy ; Carcinoma, Squamous Cell - therapy ; Chemoradiotherapy ; Disease-Free Survival ; DNA, Viral - analysis ; DNA-Binding Proteins - biosynthesis ; Female ; HPV-16 ; Human papillomavirus 16 - genetics ; Human papillomavirus 16 - isolation & purification ; Humans ; Immunohistochemistry ; Lymphocytes, Tumor-Infiltrating ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Proteins - biosynthesis ; Neoplasm Recurrence, Local - drug therapy ; Neoplasm Recurrence, Local - metabolism ; Neoplasm Recurrence, Local - radiotherapy ; Prognosis ; Prognostic marker ; Retrospective Studies ; RITA</subject><ispartof>Radiotherapy and oncology, 2018-02, Vol.126 (2), p.214-221</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-c08fa4a28f723e70d9268eaa6b0acbec24fc2ed51721a9b4a4dce7999ff186753</citedby><cites>FETCH-LOGICAL-c362t-c08fa4a28f723e70d9268eaa6b0acbec24fc2ed51721a9b4a4dce7999ff186753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.radonc.2017.10.028$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29122359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rödel, Franz</creatorcontrib><creatorcontrib>Steinhäuser, Kerstin</creatorcontrib><creatorcontrib>Kreis, Nina-Naomi</creatorcontrib><creatorcontrib>Friemel, Alexandra</creatorcontrib><creatorcontrib>Martin, Daniel</creatorcontrib><creatorcontrib>Wieland, Ulrike</creatorcontrib><creatorcontrib>Rave-Fränk, Margret</creatorcontrib><creatorcontrib>Balermpas, Panagiotis</creatorcontrib><creatorcontrib>Fokas, Emmanouil</creatorcontrib><creatorcontrib>Louwen, Frank</creatorcontrib><creatorcontrib>Rödel, Claus</creatorcontrib><creatorcontrib>Yuan, Juping</creatorcontrib><title>Prognostic impact of RITA expression in patients with anal squamous cell carcinoma treated with chemoradiotherapy</title><title>Radiotherapy and oncology</title><addtitle>Radiother Oncol</addtitle><description>RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notch signalling pathway and its deregulation is involved in the pathogenesis of several tumour entities. RITA’s impact on the response of anal squamous cell carcinoma (SCC) to anticancer treatment, however, remains elusive.
In our retrospective study immunohistochemical evaluation of RITA was performed on 140 pre-treatment specimens and was correlated with clinical and histopathologic characteristics and clinical endpoints cumulative incidence of local control (LC), distant recurrence (DC), disease-free survival (DFS) and overall survival (OS).
We observed significant inverse correlations between RITA expression and tumour grading, the levels of HPV-16 virus DNA load, CD8 (+) tumour infiltrating lymphocytes and programmed death protein (PD-1) immunostaining. In univariate analyses, elevated levels of RITA expression were predictive for decreased local control (p = 0.001), decreased distant control (p = 0.040), decreased disease free survival (p = 0.001) and overall survival (p < 0.0001), whereas in multivariate analyses RITA expression remained significant for decreased local control (p = 0.009), disease free survival (p = 0.032) and overall survival (p = 0.012).
These data indicate that elevated levels of pretreatment RITA expression are correlated with unfavourable clinical outcome in anal carcinoma treated with concomitant chemoradiotherapy.</description><subject>Anal cancer</subject><subject>Anus Neoplasms - drug therapy</subject><subject>Anus Neoplasms - metabolism</subject><subject>Anus Neoplasms - radiotherapy</subject><subject>Anus Neoplasms - therapy</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Chemoradiotherapy</subject><subject>Disease-Free Survival</subject><subject>DNA, Viral - analysis</subject><subject>DNA-Binding Proteins - biosynthesis</subject><subject>Female</subject><subject>HPV-16</subject><subject>Human papillomavirus 16 - genetics</subject><subject>Human papillomavirus 16 - isolation & purification</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphocytes, Tumor-Infiltrating</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Recurrence, Local - drug therapy</subject><subject>Neoplasm Recurrence, Local - metabolism</subject><subject>Neoplasm Recurrence, Local - radiotherapy</subject><subject>Prognosis</subject><subject>Prognostic marker</subject><subject>Retrospective Studies</subject><subject>RITA</subject><issn>0167-8140</issn><issn>1879-0887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFqGzEQhkVpaRy3b1CKjr2sK2nXK-lSCCFNAoGWkp7FeHa2lvGu1pKcNG9fmU16zGlg-Gbmn4-xT1KspJDt190qQhdGXCkhdWmthDJv2EIabSthjH7LFgXTlZGNOGPnKe2EEErU-j07U1YqVa_tgh1-xvBnDCl75H6YADMPPf91e3_B6e8UKSUfRu5HPkH2NObEH33echhhz9PhCEM4Jo6033OEiH4MA_AcCTJ1M4lbGkJJ6kPeUoTp6QN718M-0cfnumS_v1_dX95Udz-uby8v7iqsW5UrFKaHBpTptapJi86q1hBAuxGAG0LV9KioW0utJNhNA02HpK21fS9Nq9f1kn2Z904xHI6Usht8OiWFkUpoJ21bKy2LqoI2M4oxpBSpd1P0A8QnJ4U7yXY7N8t2J9mnbpFdxj4_XzhuBur-D73YLcC3GaDy54On6BIWiUidj4TZdcG_fuEf48uU7Q</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Rödel, Franz</creator><creator>Steinhäuser, Kerstin</creator><creator>Kreis, Nina-Naomi</creator><creator>Friemel, Alexandra</creator><creator>Martin, Daniel</creator><creator>Wieland, Ulrike</creator><creator>Rave-Fränk, Margret</creator><creator>Balermpas, Panagiotis</creator><creator>Fokas, Emmanouil</creator><creator>Louwen, Frank</creator><creator>Rödel, Claus</creator><creator>Yuan, Juping</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201802</creationdate><title>Prognostic impact of RITA expression in patients with anal squamous cell carcinoma treated with chemoradiotherapy</title><author>Rödel, Franz ; Steinhäuser, Kerstin ; Kreis, Nina-Naomi ; Friemel, Alexandra ; Martin, Daniel ; Wieland, Ulrike ; Rave-Fränk, Margret ; Balermpas, Panagiotis ; Fokas, Emmanouil ; Louwen, Frank ; Rödel, Claus ; Yuan, Juping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-c08fa4a28f723e70d9268eaa6b0acbec24fc2ed51721a9b4a4dce7999ff186753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anal cancer</topic><topic>Anus Neoplasms - drug therapy</topic><topic>Anus Neoplasms - metabolism</topic><topic>Anus Neoplasms - radiotherapy</topic><topic>Anus Neoplasms - therapy</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Chemoradiotherapy</topic><topic>Disease-Free Survival</topic><topic>DNA, Viral - analysis</topic><topic>DNA-Binding Proteins - biosynthesis</topic><topic>Female</topic><topic>HPV-16</topic><topic>Human papillomavirus 16 - genetics</topic><topic>Human papillomavirus 16 - isolation & purification</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphocytes, Tumor-Infiltrating</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Neoplasm Recurrence, Local - drug therapy</topic><topic>Neoplasm Recurrence, Local - metabolism</topic><topic>Neoplasm Recurrence, Local - radiotherapy</topic><topic>Prognosis</topic><topic>Prognostic marker</topic><topic>Retrospective Studies</topic><topic>RITA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rödel, Franz</creatorcontrib><creatorcontrib>Steinhäuser, Kerstin</creatorcontrib><creatorcontrib>Kreis, Nina-Naomi</creatorcontrib><creatorcontrib>Friemel, Alexandra</creatorcontrib><creatorcontrib>Martin, Daniel</creatorcontrib><creatorcontrib>Wieland, Ulrike</creatorcontrib><creatorcontrib>Rave-Fränk, Margret</creatorcontrib><creatorcontrib>Balermpas, Panagiotis</creatorcontrib><creatorcontrib>Fokas, Emmanouil</creatorcontrib><creatorcontrib>Louwen, Frank</creatorcontrib><creatorcontrib>Rödel, Claus</creatorcontrib><creatorcontrib>Yuan, Juping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiotherapy and oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rödel, Franz</au><au>Steinhäuser, Kerstin</au><au>Kreis, Nina-Naomi</au><au>Friemel, Alexandra</au><au>Martin, Daniel</au><au>Wieland, Ulrike</au><au>Rave-Fränk, Margret</au><au>Balermpas, Panagiotis</au><au>Fokas, Emmanouil</au><au>Louwen, Frank</au><au>Rödel, Claus</au><au>Yuan, Juping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic impact of RITA expression in patients with anal squamous cell carcinoma treated with chemoradiotherapy</atitle><jtitle>Radiotherapy and oncology</jtitle><addtitle>Radiother Oncol</addtitle><date>2018-02</date><risdate>2018</risdate><volume>126</volume><issue>2</issue><spage>214</spage><epage>221</epage><pages>214-221</pages><issn>0167-8140</issn><eissn>1879-0887</eissn><abstract>RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notch signalling pathway and its deregulation is involved in the pathogenesis of several tumour entities. RITA’s impact on the response of anal squamous cell carcinoma (SCC) to anticancer treatment, however, remains elusive.
In our retrospective study immunohistochemical evaluation of RITA was performed on 140 pre-treatment specimens and was correlated with clinical and histopathologic characteristics and clinical endpoints cumulative incidence of local control (LC), distant recurrence (DC), disease-free survival (DFS) and overall survival (OS).
We observed significant inverse correlations between RITA expression and tumour grading, the levels of HPV-16 virus DNA load, CD8 (+) tumour infiltrating lymphocytes and programmed death protein (PD-1) immunostaining. In univariate analyses, elevated levels of RITA expression were predictive for decreased local control (p = 0.001), decreased distant control (p = 0.040), decreased disease free survival (p = 0.001) and overall survival (p < 0.0001), whereas in multivariate analyses RITA expression remained significant for decreased local control (p = 0.009), disease free survival (p = 0.032) and overall survival (p = 0.012).
These data indicate that elevated levels of pretreatment RITA expression are correlated with unfavourable clinical outcome in anal carcinoma treated with concomitant chemoradiotherapy.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>29122359</pmid><doi>10.1016/j.radonc.2017.10.028</doi><tpages>8</tpages></addata></record> |
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| ispartof | Radiotherapy and oncology, 2018-02, Vol.126 (2), p.214-221 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Anal cancer Anus Neoplasms - drug therapy Anus Neoplasms - metabolism Anus Neoplasms - radiotherapy Anus Neoplasms - therapy Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - therapy Chemoradiotherapy Disease-Free Survival DNA, Viral - analysis DNA-Binding Proteins - biosynthesis Female HPV-16 Human papillomavirus 16 - genetics Human papillomavirus 16 - isolation & purification Humans Immunohistochemistry Lymphocytes, Tumor-Infiltrating Male Middle Aged Neoplasm Grading Neoplasm Proteins - biosynthesis Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - radiotherapy Prognosis Prognostic marker Retrospective Studies RITA |
| title | Prognostic impact of RITA expression in patients with anal squamous cell carcinoma treated with chemoradiotherapy |
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