Placenta-derived PLX-PAD mesenchymal-like stromal cells are efficacious in rescuing blood flow in hind limb ischemia mouse model by a dose- and site-dependent mechanism of action

•PLX-PAD rescues blood flow in hind limb ischemia in a dose- and site-dependent manner.•Live PLX-PAD cells are more efficacious than cell lysate.•PLX-PAD secrete numerous pro-angiogenic factors.•The proposed PLX-PAD mechanism of action involves multifactorial endocrine secretion. In peripheral arter...

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Veröffentlicht in:	Cytotherapy (Oxford, England) England), 2017-12, Vol.19 (12), p.1438-1446
Hauptverfasser:	Zahavi-Goldstein, Efrat, Blumenfeld, Michal, Fuchs-Telem, Dana, Pinzur, Lena, Rubin, Shy, Aberman, Zami, Sher, Noa, Ofir, Racheli
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytokines - metabolism Disease Models, Animal Female hind limb ischemia Hindlimb - blood supply Ischemia - physiopathology Ischemia - therapy Male mesenchymal stromal cells Mesenchymal Stromal Cells - cytology Mice, Inbred C57BL Peripheral Arterial Disease - therapy placenta Placenta - cytology PLX-PAD Pregnancy Regional Blood Flow Stromal Cells - transplantation
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