Influence of Liver Fibrosis Stage on Plasma Levels of Antiretroviral Drugs in HIV-Infected Patients with Chronic Hepatitis C

Background. Most antiretrovirals are metabolized in the liver, and lower dosing could be advisable in patients with severe liver insufficiency. Methods. Plasma drug levels were measured in hepatitis C virus (HCV)/human immunodeficiency virus (HIV)—coinfected patients receiving nevirapine (NVP), efav...

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Veröffentlicht in:	The Journal of infectious diseases 2007-04, Vol.195 (7), p.973-979
Hauptverfasser:	Barreiro, Pablo, Rodríguez-Novoa, Sonia, Labarga, Pablo, Ruiz, Andrés, Jiménez-Nácher, Inmaculada, Martín-Carbonero, Luz, Gonzalez-Lahoz, Juan, Soriano, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS Anti-HIV Agents - administration & dosage Anti-HIV Agents - blood Anti-HIV Agents - therapeutic use Antiretrovirals Antivirals Atazanavir Sulfate Benzoxazines Biological and medical sciences Blood plasma Chronic hepatitis Cirrhosis Drug Monitoring Female Fibrosis Fundamental and applied biological sciences. Psychology Hepatitis C virus Hepatitis C, Chronic - blood Hepatitis C, Chronic - pathology HIV Infections - drug therapy HIV/AIDS Human immunodeficiency virus Human viral diseases Humans Infectious diseases Liver Liver Cirrhosis - pathology Liver diseases Lopinavir Male Medical sciences Microbiology Nevirapine - administration & dosage Nevirapine - blood Nevirapine - therapeutic use Oligopeptides - administration & dosage Oligopeptides - blood Oligopeptides - therapeutic use Oxazines - administration & dosage Oxazines - blood Oxazines - therapeutic use Pharmacokinetics Pyridines - administration & dosage Pyridines - blood Pyridines - therapeutic use Pyrimidinones - administration & dosage Pyrimidinones - blood Pyrimidinones - therapeutic use Ritonavir - administration & dosage Ritonavir - blood Ritonavir - therapeutic use Severity of Illness Index Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral hepatitis
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