Imbalance between CaM kinase II and calcineurin activities impairs caffeine-induced calcium release in hypertrophic cardiomyocytes

Cardiac hypertrophy impairs Ca 2+ handling in the sarcoplasmic reticulum, thereby impairing cardiac contraction. To identify the mechanisms underlying impaired Ca 2+ release from the sarcoplasmic reticulum in hypertrophic cardiomyocytes, we assessed Ca 2+-dependent signaling and the phosphorylation...

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