Intestinal immunity of rats with colon cancer is modulated by oligofructose-enriched inulin combined with Lactobacillus rhamnosus and Bifidobacterium lactis
Probiotics (PRO) are known to modulate immunity in animals and human subjects and to inhibit colon carcinogenesis in experimental models, but the effects of synbiotics (SYN) are not well understood. Therefore, the effects of PRO (Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12), PRE (inul...
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| Veröffentlicht in: | British journal of nutrition 2004-12, Vol.92 (6), p.931-938 |
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| creator | Roller, Monika Femia, Angelo Pietro Caderni, Giovanna Rechkemmer, Gerhard Watzl, Bernhard |
| description | Probiotics (PRO) are known to modulate immunity in animals and human subjects and to inhibit colon carcinogenesis in experimental models, but the effects of synbiotics (SYN) are not well understood. Therefore, the effects of PRO (Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12), PRE (inulin-based enriched with oligofructose, 100g/kg) and SYN (combination of PRO and PRE) on the immune system of rats were investigated in the azoxymethane (AOM)-induced colon cancer model. After 33 weeks, rats with and without AOM treatment were killed and immune cells were isolated from spleen, mesenterial lymph nodes (MLN) and Peyer's patches (PP). AOM treatment significantly reduced natural killer (NK) cell-like cytotoxicity in control rats and in PRO- and PRE-supplemented rats. SYN supplementation prevented the AOM-induced suppression of NK cell-like cytotoxicity in PP compared with control rats (P |
| doi_str_mv | 10.1079/BJN20041289 |
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Therefore, the effects of PRO (Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12), PRE (inulin-based enriched with oligofructose, 100g/kg) and SYN (combination of PRO and PRE) on the immune system of rats were investigated in the azoxymethane (AOM)-induced colon cancer model. After 33 weeks, rats with and without AOM treatment were killed and immune cells were isolated from spleen, mesenterial lymph nodes (MLN) and Peyer's patches (PP). AOM treatment significantly reduced natural killer (NK) cell-like cytotoxicity in control rats and in PRO- and PRE-supplemented rats. SYN supplementation prevented the AOM-induced suppression of NK cell-like cytotoxicity in PP compared with control rats (P<0·01). SYN and PRE supplementation stimulated IL-10 production in PP in these rats (P<0·01) and in MLN of rats not treated with AOM (P<0·05). Interferon-γ production in PP was decreased by PRO supplementation (PRO and SYN groups combined; P<0·05). Proliferative responsiveness of lymphocytes (PP) from AOM-treated rats was suppressed in SYN-supplemented rats (P<0·01). Overall, SYN supplementation in carcinogen-treated rats primarily modulated immune functions in the PP, coinciding with a reduced number of colon tumours. PRE and PRO provided in combination as SYN may contribute to the suppression of colon carcinogenesis by modulating the gut-associated lymphoid tissue.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN20041289</identifier><identifier>PMID: 15613255</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Animals ; Azoxymethane ; Bifidobacterium ; Bifidobacterium lactis ; Biological and medical sciences ; Carcinogenesis ; Carcinogens ; Cell Division - immunology ; Colon cancer ; Colonic Neoplasms - chemically induced ; Colonic Neoplasms - immunology ; Colorectal cancer ; Cytotoxicity ; Diet ; Disease Models, Animal ; Gastroenterology. Liver. Pancreas. Abdomen ; Human subjects ; Immune system ; Interferons - biosynthesis ; Interleukin-10 - biosynthesis ; Inulin - administration & dosage ; Killer Cells, Natural - drug effects ; Killer Cells, Natural - immunology ; Lactobacillus ; Lactobacillus rhamnosus ; Lymph nodes ; Lymph Nodes - drug effects ; Lymph Nodes - immunology ; Lymphatic system ; Lymphocyte Subsets - immunology ; Lymphocytes ; Male ; Medical sciences ; Nutrition research ; Oligosaccharides - administration & dosage ; Peyer's Patches - drug effects ; Peyer's Patches - immunology ; Prebiotic ; Prebiotics ; Probiotic ; Probiotics ; Probiotics - administration & dosage ; Probiotics - pharmacology ; Rat ; Rats ; Rats, Inbred F344 ; Spleen ; Spleen - drug effects ; Spleen - immunology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Synbiotic ; Tumors</subject><ispartof>British journal of nutrition, 2004-12, Vol.92 (6), p.931-938</ispartof><rights>Copyright © The Nutrition Society 2004</rights><rights>2005 INIST-CNRS</rights><rights>The Nutrition Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-418d6a4f5f1e5f4be1eda5376a3df83cc4f53795044cfb39749d0f1540df08253</citedby><cites>FETCH-LOGICAL-c554t-418d6a4f5f1e5f4be1eda5376a3df83cc4f53795044cfb39749d0f1540df08253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16426209$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15613255$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roller, Monika</creatorcontrib><creatorcontrib>Femia, Angelo Pietro</creatorcontrib><creatorcontrib>Caderni, Giovanna</creatorcontrib><creatorcontrib>Rechkemmer, Gerhard</creatorcontrib><creatorcontrib>Watzl, Bernhard</creatorcontrib><title>Intestinal immunity of rats with colon cancer is modulated by oligofructose-enriched inulin combined with Lactobacillus rhamnosus and Bifidobacterium lactis</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Probiotics (PRO) are known to modulate immunity in animals and human subjects and to inhibit colon carcinogenesis in experimental models, but the effects of synbiotics (SYN) are not well understood. Therefore, the effects of PRO (Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12), PRE (inulin-based enriched with oligofructose, 100g/kg) and SYN (combination of PRO and PRE) on the immune system of rats were investigated in the azoxymethane (AOM)-induced colon cancer model. After 33 weeks, rats with and without AOM treatment were killed and immune cells were isolated from spleen, mesenterial lymph nodes (MLN) and Peyer's patches (PP). AOM treatment significantly reduced natural killer (NK) cell-like cytotoxicity in control rats and in PRO- and PRE-supplemented rats. SYN supplementation prevented the AOM-induced suppression of NK cell-like cytotoxicity in PP compared with control rats (P<0·01). SYN and PRE supplementation stimulated IL-10 production in PP in these rats (P<0·01) and in MLN of rats not treated with AOM (P<0·05). Interferon-γ production in PP was decreased by PRO supplementation (PRO and SYN groups combined; P<0·05). Proliferative responsiveness of lymphocytes (PP) from AOM-treated rats was suppressed in SYN-supplemented rats (P<0·01). Overall, SYN supplementation in carcinogen-treated rats primarily modulated immune functions in the PP, coinciding with a reduced number of colon tumours. PRE and PRO provided in combination as SYN may contribute to the suppression of colon carcinogenesis by modulating the gut-associated lymphoid tissue.</description><subject>Animals</subject><subject>Azoxymethane</subject><subject>Bifidobacterium</subject><subject>Bifidobacterium lactis</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Cell Division - immunology</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - chemically induced</subject><subject>Colonic Neoplasms - immunology</subject><subject>Colorectal cancer</subject><subject>Cytotoxicity</subject><subject>Diet</subject><subject>Disease Models, Animal</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Human subjects</subject><subject>Immune system</subject><subject>Interferons - biosynthesis</subject><subject>Interleukin-10 - biosynthesis</subject><subject>Inulin - administration & dosage</subject><subject>Killer Cells, Natural - drug effects</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lactobacillus</subject><subject>Lactobacillus rhamnosus</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - drug effects</subject><subject>Lymph Nodes - immunology</subject><subject>Lymphatic system</subject><subject>Lymphocyte Subsets - immunology</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nutrition research</subject><subject>Oligosaccharides - administration & dosage</subject><subject>Peyer's Patches - drug effects</subject><subject>Peyer's Patches - immunology</subject><subject>Prebiotic</subject><subject>Prebiotics</subject><subject>Probiotic</subject><subject>Probiotics</subject><subject>Probiotics - administration & dosage</subject><subject>Probiotics - pharmacology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Spleen</subject><subject>Spleen - drug effects</subject><subject>Spleen - immunology</subject><subject>Stomach. 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Anus</subject><subject>Synbiotic</subject><subject>Tumors</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkUtvEzEUhUcIRNPCij1YSLBBA37PzJJWEIoiECqFpeXxI3Hxo9gzKv0v_FgcEhGEWPlenc_n6t7TNI8QfIlgN7w6ff8BQ0gR7oc7zQLRjrWYc3y3WUAIuxYhyo6a41KuatsjONxvjhDjiGDGFs3P8ziZMrkoPXAhzNFNtyBZkOVUwI2bNkAlnyJQMiqTgSsgJD17ORkNxkp6t042z2pKxbQmZqc2VXFx9q5-SmF0sfa_jVayUqNUzvu5gLyRIaZSKxk1OHXW6a04mezmAHytXHnQ3LPSF_Nw_540l2_ffD57164-Ls_PXq9axRidWop6zSW1zCLDLB0NMloy0nFJtO2JUlUi3cAgpcqOZOjooKFFjEJtYY8ZOWme73yvc_o-13OI4Ioy3sto0lwEGjiBPScVfPoPeJXmXG9XBEakJ5jjvkIvdpDKqZRsrLjOLsh8KxAU28TEX4lV-vHech6D0Qd2H1EFnu0BWZT0NtckXDlwnNapcGvU7jhXJvPjjy7zN8E70jHBl5_EsILs68WXpaCVf7LjrUxCrnP1vLzAEBGIICaUoYOjkmHMTq_NYd3_rfILOK7G-w</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Roller, Monika</creator><creator>Femia, Angelo Pietro</creator><creator>Caderni, Giovanna</creator><creator>Rechkemmer, Gerhard</creator><creator>Watzl, Bernhard</creator><general>Cambridge University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20041201</creationdate><title>Intestinal immunity of rats with colon cancer is modulated by oligofructose-enriched inulin combined with Lactobacillus rhamnosus and Bifidobacterium lactis</title><author>Roller, Monika ; Femia, Angelo Pietro ; Caderni, Giovanna ; Rechkemmer, Gerhard ; Watzl, Bernhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-418d6a4f5f1e5f4be1eda5376a3df83cc4f53795044cfb39749d0f1540df08253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Azoxymethane</topic><topic>Bifidobacterium</topic><topic>Bifidobacterium lactis</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis</topic><topic>Carcinogens</topic><topic>Cell Division - immunology</topic><topic>Colon cancer</topic><topic>Colonic Neoplasms - chemically induced</topic><topic>Colonic Neoplasms - immunology</topic><topic>Colorectal cancer</topic><topic>Cytotoxicity</topic><topic>Diet</topic><topic>Disease Models, Animal</topic><topic>Gastroenterology. 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Therefore, the effects of PRO (Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12), PRE (inulin-based enriched with oligofructose, 100g/kg) and SYN (combination of PRO and PRE) on the immune system of rats were investigated in the azoxymethane (AOM)-induced colon cancer model. After 33 weeks, rats with and without AOM treatment were killed and immune cells were isolated from spleen, mesenterial lymph nodes (MLN) and Peyer's patches (PP). AOM treatment significantly reduced natural killer (NK) cell-like cytotoxicity in control rats and in PRO- and PRE-supplemented rats. SYN supplementation prevented the AOM-induced suppression of NK cell-like cytotoxicity in PP compared with control rats (P<0·01). SYN and PRE supplementation stimulated IL-10 production in PP in these rats (P<0·01) and in MLN of rats not treated with AOM (P<0·05). Interferon-γ production in PP was decreased by PRO supplementation (PRO and SYN groups combined; P<0·05). Proliferative responsiveness of lymphocytes (PP) from AOM-treated rats was suppressed in SYN-supplemented rats (P<0·01). Overall, SYN supplementation in carcinogen-treated rats primarily modulated immune functions in the PP, coinciding with a reduced number of colon tumours. PRE and PRO provided in combination as SYN may contribute to the suppression of colon carcinogenesis by modulating the gut-associated lymphoid tissue.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>15613255</pmid><doi>10.1079/BJN20041289</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Azoxymethane Bifidobacterium Bifidobacterium lactis Biological and medical sciences Carcinogenesis Carcinogens Cell Division - immunology Colon cancer Colonic Neoplasms - chemically induced Colonic Neoplasms - immunology Colorectal cancer Cytotoxicity Diet Disease Models, Animal Gastroenterology. Liver. Pancreas. Abdomen Human subjects Immune system Interferons - biosynthesis Interleukin-10 - biosynthesis Inulin - administration & dosage Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Lactobacillus Lactobacillus rhamnosus Lymph nodes Lymph Nodes - drug effects Lymph Nodes - immunology Lymphatic system Lymphocyte Subsets - immunology Lymphocytes Male Medical sciences Nutrition research Oligosaccharides - administration & dosage Peyer's Patches - drug effects Peyer's Patches - immunology Prebiotic Prebiotics Probiotic Probiotics Probiotics - administration & dosage Probiotics - pharmacology Rat Rats Rats, Inbred F344 Spleen Spleen - drug effects Spleen - immunology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Synbiotic Tumors |
| title | Intestinal immunity of rats with colon cancer is modulated by oligofructose-enriched inulin combined with Lactobacillus rhamnosus and Bifidobacterium lactis |
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