Antiretroviral Therapy during Tuberculosis Treatment and Marked Reduction in Death Rate of HIV-lnfected Patients, Thailand
Antiretroviral therapy (ART) is lifesaving in patients with advanced HIV infection, but the magnitude of benefit in HIV-infected patients receiving tuberculosis (TB) treatment remains uncertain, and population-based data from developing countries are limited. We prospectively collected data about HI...
Gespeichert in:
| Veröffentlicht in: | Emerging infectious diseases 2007-07, Vol.13 (7) |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 7 |
| container_start_page | |
| container_title | Emerging infectious diseases |
| container_volume | 13 |
| creator | Akksilp, S Karnkawinpong, O Wattanaamornkiat, W Viriyakitja, D Monkongdee, P Sitti, W Rienthong, D Siraprapasiri, T Wells, C D Tappero, J W Varma, J K |
| description | Antiretroviral therapy (ART) is lifesaving in patients with advanced HIV infection, but the magnitude of benefit in HIV-infected patients receiving tuberculosis (TB) treatment remains uncertain, and population-based data from developing countries are limited. We prospectively collected data about HIV-infected TB patients from February 2003 through January 2004 in Ubon-ratchathani, Thailand. During 12 months, HIV was diagnosed in 329 (14%) of 2,342 patients registered for TB treatment. Of patients with known outcomes, death during TB treatment occurred in 5 (7%) of 71 who received ART and 94 (43%) of 219 who did not. Using multivariate analysis, we found a large reduction in the odds of death for patients receiving ART before or during TB treatment (odds ratio, 0.2; 95% confidence interval, 0.1-0.5), adjusting for CD4 count, smear status, co-trimoxazole use, and treatment facility. ART is associated with a substantial reduction in deaths during TB treatment for HIV-infected TB patients in Thailand. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_19630605</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19630605</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_196306053</originalsourceid><addsrcrecordid>eNqNzb1OA0EMBOAtQCL8vIMrKk7yJXAiJeJHoUBC0Yk2Mnc-YtjsBtuLBE_PFjwA1TTfzByEWYvX2HR4iUfh2OwdsZ1ju5yFn5vkouyav0QpQr9lpf03jEUlvUFfXlmHErOJQa9MvuPkQGmEJ9IPHmHNYxlccgJJcFfBFtbkDHmC1eNLE9PEg1f3TC61ahf1giTWhdNwOFE0PvvLk3D-cN_frpq95s_C5pud2MCxWs7FNu2yW2CHV4t_w1-n2VDd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19630605</pqid></control><display><type>article</type><title>Antiretroviral Therapy during Tuberculosis Treatment and Marked Reduction in Death Rate of HIV-lnfected Patients, Thailand</title><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Akksilp, S ; Karnkawinpong, O ; Wattanaamornkiat, W ; Viriyakitja, D ; Monkongdee, P ; Sitti, W ; Rienthong, D ; Siraprapasiri, T ; Wells, C D ; Tappero, J W ; Varma, J K</creator><creatorcontrib>Akksilp, S ; Karnkawinpong, O ; Wattanaamornkiat, W ; Viriyakitja, D ; Monkongdee, P ; Sitti, W ; Rienthong, D ; Siraprapasiri, T ; Wells, C D ; Tappero, J W ; Varma, J K</creatorcontrib><description>Antiretroviral therapy (ART) is lifesaving in patients with advanced HIV infection, but the magnitude of benefit in HIV-infected patients receiving tuberculosis (TB) treatment remains uncertain, and population-based data from developing countries are limited. We prospectively collected data about HIV-infected TB patients from February 2003 through January 2004 in Ubon-ratchathani, Thailand. During 12 months, HIV was diagnosed in 329 (14%) of 2,342 patients registered for TB treatment. Of patients with known outcomes, death during TB treatment occurred in 5 (7%) of 71 who received ART and 94 (43%) of 219 who did not. Using multivariate analysis, we found a large reduction in the odds of death for patients receiving ART before or during TB treatment (odds ratio, 0.2; 95% confidence interval, 0.1-0.5), adjusting for CD4 count, smear status, co-trimoxazole use, and treatment facility. ART is associated with a substantial reduction in deaths during TB treatment for HIV-infected TB patients in Thailand.</description><identifier>ISSN: 1080-6040</identifier><language>eng</language><subject>Human immunodeficiency virus ; Mycobacterium</subject><ispartof>Emerging infectious diseases, 2007-07, Vol.13 (7)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782</link.rule.ids></links><search><creatorcontrib>Akksilp, S</creatorcontrib><creatorcontrib>Karnkawinpong, O</creatorcontrib><creatorcontrib>Wattanaamornkiat, W</creatorcontrib><creatorcontrib>Viriyakitja, D</creatorcontrib><creatorcontrib>Monkongdee, P</creatorcontrib><creatorcontrib>Sitti, W</creatorcontrib><creatorcontrib>Rienthong, D</creatorcontrib><creatorcontrib>Siraprapasiri, T</creatorcontrib><creatorcontrib>Wells, C D</creatorcontrib><creatorcontrib>Tappero, J W</creatorcontrib><creatorcontrib>Varma, J K</creatorcontrib><title>Antiretroviral Therapy during Tuberculosis Treatment and Marked Reduction in Death Rate of HIV-lnfected Patients, Thailand</title><title>Emerging infectious diseases</title><description>Antiretroviral therapy (ART) is lifesaving in patients with advanced HIV infection, but the magnitude of benefit in HIV-infected patients receiving tuberculosis (TB) treatment remains uncertain, and population-based data from developing countries are limited. We prospectively collected data about HIV-infected TB patients from February 2003 through January 2004 in Ubon-ratchathani, Thailand. During 12 months, HIV was diagnosed in 329 (14%) of 2,342 patients registered for TB treatment. Of patients with known outcomes, death during TB treatment occurred in 5 (7%) of 71 who received ART and 94 (43%) of 219 who did not. Using multivariate analysis, we found a large reduction in the odds of death for patients receiving ART before or during TB treatment (odds ratio, 0.2; 95% confidence interval, 0.1-0.5), adjusting for CD4 count, smear status, co-trimoxazole use, and treatment facility. ART is associated with a substantial reduction in deaths during TB treatment for HIV-infected TB patients in Thailand.</description><subject>Human immunodeficiency virus</subject><subject>Mycobacterium</subject><issn>1080-6040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNzb1OA0EMBOAtQCL8vIMrKk7yJXAiJeJHoUBC0Yk2Mnc-YtjsBtuLBE_PFjwA1TTfzByEWYvX2HR4iUfh2OwdsZ1ju5yFn5vkouyav0QpQr9lpf03jEUlvUFfXlmHErOJQa9MvuPkQGmEJ9IPHmHNYxlccgJJcFfBFtbkDHmC1eNLE9PEg1f3TC61ahf1giTWhdNwOFE0PvvLk3D-cN_frpq95s_C5pud2MCxWs7FNu2yW2CHV4t_w1-n2VDd</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Akksilp, S</creator><creator>Karnkawinpong, O</creator><creator>Wattanaamornkiat, W</creator><creator>Viriyakitja, D</creator><creator>Monkongdee, P</creator><creator>Sitti, W</creator><creator>Rienthong, D</creator><creator>Siraprapasiri, T</creator><creator>Wells, C D</creator><creator>Tappero, J W</creator><creator>Varma, J K</creator><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20070701</creationdate><title>Antiretroviral Therapy during Tuberculosis Treatment and Marked Reduction in Death Rate of HIV-lnfected Patients, Thailand</title><author>Akksilp, S ; Karnkawinpong, O ; Wattanaamornkiat, W ; Viriyakitja, D ; Monkongdee, P ; Sitti, W ; Rienthong, D ; Siraprapasiri, T ; Wells, C D ; Tappero, J W ; Varma, J K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_196306053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Human immunodeficiency virus</topic><topic>Mycobacterium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akksilp, S</creatorcontrib><creatorcontrib>Karnkawinpong, O</creatorcontrib><creatorcontrib>Wattanaamornkiat, W</creatorcontrib><creatorcontrib>Viriyakitja, D</creatorcontrib><creatorcontrib>Monkongdee, P</creatorcontrib><creatorcontrib>Sitti, W</creatorcontrib><creatorcontrib>Rienthong, D</creatorcontrib><creatorcontrib>Siraprapasiri, T</creatorcontrib><creatorcontrib>Wells, C D</creatorcontrib><creatorcontrib>Tappero, J W</creatorcontrib><creatorcontrib>Varma, J K</creatorcontrib><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Emerging infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akksilp, S</au><au>Karnkawinpong, O</au><au>Wattanaamornkiat, W</au><au>Viriyakitja, D</au><au>Monkongdee, P</au><au>Sitti, W</au><au>Rienthong, D</au><au>Siraprapasiri, T</au><au>Wells, C D</au><au>Tappero, J W</au><au>Varma, J K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiretroviral Therapy during Tuberculosis Treatment and Marked Reduction in Death Rate of HIV-lnfected Patients, Thailand</atitle><jtitle>Emerging infectious diseases</jtitle><date>2007-07-01</date><risdate>2007</risdate><volume>13</volume><issue>7</issue><issn>1080-6040</issn><abstract>Antiretroviral therapy (ART) is lifesaving in patients with advanced HIV infection, but the magnitude of benefit in HIV-infected patients receiving tuberculosis (TB) treatment remains uncertain, and population-based data from developing countries are limited. We prospectively collected data about HIV-infected TB patients from February 2003 through January 2004 in Ubon-ratchathani, Thailand. During 12 months, HIV was diagnosed in 329 (14%) of 2,342 patients registered for TB treatment. Of patients with known outcomes, death during TB treatment occurred in 5 (7%) of 71 who received ART and 94 (43%) of 219 who did not. Using multivariate analysis, we found a large reduction in the odds of death for patients receiving ART before or during TB treatment (odds ratio, 0.2; 95% confidence interval, 0.1-0.5), adjusting for CD4 count, smear status, co-trimoxazole use, and treatment facility. ART is associated with a substantial reduction in deaths during TB treatment for HIV-infected TB patients in Thailand.</abstract></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1080-6040 |
| ispartof | Emerging infectious diseases, 2007-07, Vol.13 (7) |
| issn | 1080-6040 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_19630605 |
| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Human immunodeficiency virus Mycobacterium |
| title | Antiretroviral Therapy during Tuberculosis Treatment and Marked Reduction in Death Rate of HIV-lnfected Patients, Thailand |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T07%3A13%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antiretroviral%20Therapy%20during%20Tuberculosis%20Treatment%20and%20Marked%20Reduction%20in%20Death%20Rate%20of%20HIV-lnfected%20Patients,%20Thailand&rft.jtitle=Emerging%20infectious%20diseases&rft.au=Akksilp,%20S&rft.date=2007-07-01&rft.volume=13&rft.issue=7&rft.issn=1080-6040&rft_id=info:doi/&rft_dat=%3Cproquest%3E19630605%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19630605&rft_id=info:pmid/&rfr_iscdi=true |