New conjugates of antitumor antibiotic doxorubicin with water-soluble galactomannan: Synthesis and biological activity

New conjugates of antitumor antibiotic doxorubicin with water-soluble galactomannan: Synthesis and biological activity

New water-soluble conjugates in the form of Schiff bases (DGM-1 and DGM-2) were prepared by the interaction of water-soluble periodate-oxidized galactomannan with doxorubicin or @@iN@-(@@iL@-lysyl)doxorubicin, respectively. The water-soluble galactomannan (DAVANAT^+, a commercial product of Pro-Phar...

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Veröffentlicht in:Russian journal of bioorganic chemistry 2007-02, Vol.33 (1), p.139-145
Hauptverfasser: Tevyashova, A. N., Olsufyeva, E. N., Preobrazhenskaya, M. N., Klyosov, A. A., Zomer, E., Platt, D.
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Cyamopsis tetragonoloba
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container_end_page 145
container_issue 1
container_start_page 139
container_title Russian journal of bioorganic chemistry
container_volume 33
creator Tevyashova, A. N.
Olsufyeva, E. N.
Preobrazhenskaya, M. N.
Klyosov, A. A.
Zomer, E.
Platt, D.
description New water-soluble conjugates in the form of Schiff bases (DGM-1 and DGM-2) were prepared by the interaction of water-soluble periodate-oxidized galactomannan with doxorubicin or @@iN@-(@@iL@-lysyl)doxorubicin, respectively. The water-soluble galactomannan (DAVANAT^+, a commercial product of Pro-Pharmaceuticals company) was obtained by partial acidic hydrolysis of high-molecular-mass galactomannan from @@iCyamopsis tetragonoloba@ (guar gum) seeds. The conjugate stability was studied in aqueous solutions. The DGM-1 anti-proliferative activity was comparable with that of doxorubicin on three models: cell lines of murine melanoma B16-F1 and human breast cancer MCF-7 (HTB-22) and human colon cancer HT-29 (HTB-38). DGM-2 was poorly active in all the three tests. DGM-1 can thus be regarded as a high-molecular-mass depot form of doxorubicin.
doi_str_mv 10.1134/S1068162007010153
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subjects Cyamopsis tetragonoloba
title New conjugates of antitumor antibiotic doxorubicin with water-soluble galactomannan: Synthesis and biological activity
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