REDUCED SUSCEPTIBILITY TO DELTAMETHRIN AND KDR MUTATION IN ANOPHELES STEPHENSI LISTON, A MALARIA VECTOR IN INDIA
The Indian urban malaria vector Anopheles stephensi Liston was selected for deltamethrin resistance for 25 generations (F25) at larval and adult stages separately in the laboratory. There was roughly a 151-fold increase in the lethal concentration (LC)50 and a 99-fold increase in the LC90 in larval...
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| Veröffentlicht in: | Journal of the American Mosquito Control Association 2006-12, Vol.22 (4), p.678-688 |
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| description | The Indian urban malaria vector Anopheles stephensi Liston was selected for deltamethrin resistance for 25 generations (F25) at larval and adult stages separately in the laboratory. There was roughly a 151-fold increase in the lethal concentration (LC)50 and a 99-fold increase in the LC90 in larval selection, when the F25 was compared with the parent colony. Similarly, adult selection resulted in a 39-fold increase in the LC50 and a 31-fold increase in the LC90 in the adults. Knockdown bioassays conducted on adults (selected at the larval and adult stages) against the diagnostic concentration of insecticide-impregnated papers, namely, deltamethrin (0.05%), permethrin (0.75%), λ-cyhalothrin (0.05%), and cyfluthrin (0.15%), revealed that the adults selected at the adult stage were more resistant to deltamethrin and the other pyrethroids than those selected at the larval stage. A significant cross-resistance to DDT was noticed only in the adults selected at the adult stage, and no cross-resistance to malathion and propoxur was observed in the adults of both resistant colonies. Polymerase chain reaction studies revealed an occurrence of heterozygote level of kdr mutation (leucine to phenylalanine) in the adults selected at the adult stage. This event was not observed in the adults selected at the larval stage. Moreover, this is the first report on the occurrence of kdr mutation in Indian An. stephensi resistant to deltamethrin. |
| doi_str_mv | 10.2987/8756-971X(2006)22[678:RSTDAK]2.0.CO;2 |
| format | Article |
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There was roughly a 151-fold increase in the lethal concentration (LC)50 and a 99-fold increase in the LC90 in larval selection, when the F25 was compared with the parent colony. Similarly, adult selection resulted in a 39-fold increase in the LC50 and a 31-fold increase in the LC90 in the adults. Knockdown bioassays conducted on adults (selected at the larval and adult stages) against the diagnostic concentration of insecticide-impregnated papers, namely, deltamethrin (0.05%), permethrin (0.75%), λ-cyhalothrin (0.05%), and cyfluthrin (0.15%), revealed that the adults selected at the adult stage were more resistant to deltamethrin and the other pyrethroids than those selected at the larval stage. A significant cross-resistance to DDT was noticed only in the adults selected at the adult stage, and no cross-resistance to malathion and propoxur was observed in the adults of both resistant colonies. Polymerase chain reaction studies revealed an occurrence of heterozygote level of kdr mutation (leucine to phenylalanine) in the adults selected at the adult stage. This event was not observed in the adults selected at the larval stage. Moreover, this is the first report on the occurrence of kdr mutation in Indian An. stephensi resistant to deltamethrin.</description><identifier>ISSN: 8756-971X</identifier><identifier>EISSN: 1943-6270</identifier><identifier>DOI: 10.2987/8756-971X(2006)22[678:RSTDAK]2.0.CO;2</identifier><identifier>PMID: 17304937</identifier><identifier>CODEN: JAMAET</identifier><language>eng</language><publisher>15000 Commerce Parkway, Suite C, Mount Laurel, NJ 08054: American Mosquito Control Association, Inc</publisher><subject>adult selection ; Animals ; Anopheles - drug effects ; Anopheles - genetics ; Anopheles stephensi ; Biological and medical sciences ; Biological Assay ; cross-resistance ; deltamethrin resistance ; DNA Primers - chemistry ; Female ; Fundamental and applied biological sciences. Psychology ; India ; Insect Vectors - drug effects ; Insect Vectors - genetics ; Insecticide Resistance - genetics ; Insecticides - toxicity ; kdr mutation ; Larva ; larval selection ; Lethal Dose 50 ; Malaria - transmission ; Medically important nuisances and vectors, pests of stored products and materials: population survey and control ; Mutation ; Nitriles - toxicity ; Polymerase Chain Reaction - veterinary ; Pyrethrins - toxicity ; Selection, Genetic ; Time Factors ; Vectors. 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There was roughly a 151-fold increase in the lethal concentration (LC)50 and a 99-fold increase in the LC90 in larval selection, when the F25 was compared with the parent colony. Similarly, adult selection resulted in a 39-fold increase in the LC50 and a 31-fold increase in the LC90 in the adults. Knockdown bioassays conducted on adults (selected at the larval and adult stages) against the diagnostic concentration of insecticide-impregnated papers, namely, deltamethrin (0.05%), permethrin (0.75%), λ-cyhalothrin (0.05%), and cyfluthrin (0.15%), revealed that the adults selected at the adult stage were more resistant to deltamethrin and the other pyrethroids than those selected at the larval stage. A significant cross-resistance to DDT was noticed only in the adults selected at the adult stage, and no cross-resistance to malathion and propoxur was observed in the adults of both resistant colonies. Polymerase chain reaction studies revealed an occurrence of heterozygote level of kdr mutation (leucine to phenylalanine) in the adults selected at the adult stage. This event was not observed in the adults selected at the larval stage. Moreover, this is the first report on the occurrence of kdr mutation in Indian An. stephensi resistant to deltamethrin.</description><subject>adult selection</subject><subject>Animals</subject><subject>Anopheles - drug effects</subject><subject>Anopheles - genetics</subject><subject>Anopheles stephensi</subject><subject>Biological and medical sciences</subject><subject>Biological Assay</subject><subject>cross-resistance</subject><subject>deltamethrin resistance</subject><subject>DNA Primers - chemistry</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>India</subject><subject>Insect Vectors - drug effects</subject><subject>Insect Vectors - genetics</subject><subject>Insecticide Resistance - genetics</subject><subject>Insecticides - toxicity</subject><subject>kdr mutation</subject><subject>Larva</subject><subject>larval selection</subject><subject>Lethal Dose 50</subject><subject>Malaria - transmission</subject><subject>Medically important nuisances and vectors, pests of stored products and materials: population survey and control</subject><subject>Mutation</subject><subject>Nitriles - toxicity</subject><subject>Polymerase Chain Reaction - veterinary</subject><subject>Pyrethrins - toxicity</subject><subject>Selection, Genetic</subject><subject>Time Factors</subject><subject>Vectors. Intermediate hosts</subject><issn>8756-971X</issn><issn>1943-6270</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqdkMGO0zAQhi0EYsvCKyBfQCCRYjuJHS8nkxhqbZqsEheBELKcxJGK2qbE2wNvT0Ir9s5pRqNv_hl9AAQYLQlP2PuExTTgDH99QxCibwn5TllyU9U6E7c_yBIt0_IDeQQWmEdhQAlDj8Hi384VeOb9T4RIHMfRU3CFWYgiHrIFOFYy26Qyg_WmTuWdVh9VrvQ3qEuYyVyLtdSrShVQFBm8zSq43mihVVnAv7PybiVzWcNay6kragVzVeuyeAcFXItcVErALzLVZTXzqsiUeA6e9Hbn3YtLvQabT1KnqyAvP6tU5EETUXQf9LbnxDnkOksT1CQktl1oGWVd1LmIoyaMEcGcxRwj2joywW1r46SLO85d2ITX4PU59zgOv07O35v91rdut7MHN5y8wZySBDE6gfIMtuPg_eh6cxy3ezv-NhiZWb2ZNZpZo5nVG0LMpN6c1RtikElLQ6acl5eDp2bvuoeUi-sJeHUBrG_trh_tod36By6JMOLh_FB65prtMBzcf77zB-komuQ</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>GAYATHRI, V</creator><creator>MURTHY, P BALAKRISHNA</creator><general>American Mosquito Control Association, Inc</general><general>American Mosquito Control Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20061201</creationdate><title>REDUCED SUSCEPTIBILITY TO DELTAMETHRIN AND KDR MUTATION IN ANOPHELES STEPHENSI LISTON, A MALARIA VECTOR IN INDIA</title><author>GAYATHRI, V ; MURTHY, P BALAKRISHNA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b460t-faf92ee0eda680b825ad3a767d4de490b350219759106ce292ecca58d5d99e3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>adult selection</topic><topic>Animals</topic><topic>Anopheles - drug effects</topic><topic>Anopheles - genetics</topic><topic>Anopheles stephensi</topic><topic>Biological and medical sciences</topic><topic>Biological Assay</topic><topic>cross-resistance</topic><topic>deltamethrin resistance</topic><topic>DNA Primers - chemistry</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>India</topic><topic>Insect Vectors - drug effects</topic><topic>Insect Vectors - genetics</topic><topic>Insecticide Resistance - genetics</topic><topic>Insecticides - toxicity</topic><topic>kdr mutation</topic><topic>Larva</topic><topic>larval selection</topic><topic>Lethal Dose 50</topic><topic>Malaria - transmission</topic><topic>Medically important nuisances and vectors, pests of stored products and materials: population survey and control</topic><topic>Mutation</topic><topic>Nitriles - toxicity</topic><topic>Polymerase Chain Reaction - veterinary</topic><topic>Pyrethrins - toxicity</topic><topic>Selection, Genetic</topic><topic>Time Factors</topic><topic>Vectors. Intermediate hosts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GAYATHRI, V</creatorcontrib><creatorcontrib>MURTHY, P BALAKRISHNA</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Journal of the American Mosquito Control Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GAYATHRI, V</au><au>MURTHY, P BALAKRISHNA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>REDUCED SUSCEPTIBILITY TO DELTAMETHRIN AND KDR MUTATION IN ANOPHELES STEPHENSI LISTON, A MALARIA VECTOR IN INDIA</atitle><jtitle>Journal of the American Mosquito Control Association</jtitle><addtitle>J Am Mosq Control Assoc</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>22</volume><issue>4</issue><spage>678</spage><epage>688</epage><pages>678-688</pages><issn>8756-971X</issn><eissn>1943-6270</eissn><coden>JAMAET</coden><abstract>The Indian urban malaria vector Anopheles stephensi Liston was selected for deltamethrin resistance for 25 generations (F25) at larval and adult stages separately in the laboratory. There was roughly a 151-fold increase in the lethal concentration (LC)50 and a 99-fold increase in the LC90 in larval selection, when the F25 was compared with the parent colony. Similarly, adult selection resulted in a 39-fold increase in the LC50 and a 31-fold increase in the LC90 in the adults. Knockdown bioassays conducted on adults (selected at the larval and adult stages) against the diagnostic concentration of insecticide-impregnated papers, namely, deltamethrin (0.05%), permethrin (0.75%), λ-cyhalothrin (0.05%), and cyfluthrin (0.15%), revealed that the adults selected at the adult stage were more resistant to deltamethrin and the other pyrethroids than those selected at the larval stage. A significant cross-resistance to DDT was noticed only in the adults selected at the adult stage, and no cross-resistance to malathion and propoxur was observed in the adults of both resistant colonies. Polymerase chain reaction studies revealed an occurrence of heterozygote level of kdr mutation (leucine to phenylalanine) in the adults selected at the adult stage. This event was not observed in the adults selected at the larval stage. Moreover, this is the first report on the occurrence of kdr mutation in Indian An. stephensi resistant to deltamethrin.</abstract><cop>15000 Commerce Parkway, Suite C, Mount Laurel, NJ 08054</cop><pub>American Mosquito Control Association, Inc</pub><pmid>17304937</pmid><doi>10.2987/8756-971X(2006)22[678:RSTDAK]2.0.CO;2</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8756-971X |
| ispartof | Journal of the American Mosquito Control Association, 2006-12, Vol.22 (4), p.678-688 |
| issn | 8756-971X 1943-6270 |
| language | eng |
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| subjects | adult selection Animals Anopheles - drug effects Anopheles - genetics Anopheles stephensi Biological and medical sciences Biological Assay cross-resistance deltamethrin resistance DNA Primers - chemistry Female Fundamental and applied biological sciences. Psychology India Insect Vectors - drug effects Insect Vectors - genetics Insecticide Resistance - genetics Insecticides - toxicity kdr mutation Larva larval selection Lethal Dose 50 Malaria - transmission Medically important nuisances and vectors, pests of stored products and materials: population survey and control Mutation Nitriles - toxicity Polymerase Chain Reaction - veterinary Pyrethrins - toxicity Selection, Genetic Time Factors Vectors. Intermediate hosts |
| title | REDUCED SUSCEPTIBILITY TO DELTAMETHRIN AND KDR MUTATION IN ANOPHELES STEPHENSI LISTON, A MALARIA VECTOR IN INDIA |
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