Novel Gold and Silver Carbene Complexes Exert Antitumor Effects Triggering the Reactive Oxygen Species Dependent Intrinsic Apoptotic Pathway

Cisplatin and other platinum‐based drugs are well‐known valid anticancer drugs. However, during chemotherapy, the presence of numerous side effects and the onset of frequent phenomena of resistance has pushed many research groups to devise new metal‐based compounds holding improved anticancer proper...

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Veröffentlicht in:	ChemMedChem 2017-12, Vol.12 (24), p.2054-2065
Hauptverfasser:	Iacopetta, Domenico, Mariconda, Annaluisa, Saturnino, Carmela, Caruso, Anna, Palma, Giuseppe, Ceramella, Jessica, Muià, Noemi, Perri, Mariarita, Sinicropi, Maria Stefania, Caroleo, Maria Cristina, Longo, Pasquale
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic drugs Antitumor activity Antitumor agents Apoptosis Apoptosis - drug effects Breast cancer Cancer Cancer therapies carbenes caspases Cell culture Cell death Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Chemotherapy Cisplatin cytochromes Cytoplasm Cytotoxicity Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Gold Gold - chemistry Gold - pharmacology HeLa cells Humans Methane - analogs & derivatives Methane - chemistry Methane - pharmacology Mitochondria Mitochondria - drug effects Mitochondria - metabolism Organometallic compounds Ovarian cancer Platinum Poly(ADP-ribose) polymerase Reactive oxygen species Reactive Oxygen Species - metabolism Side effects Silver Silver - chemistry Silver - pharmacology Structure-Activity Relationship Synthesis transmetalation Tumor cell lines
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