Nodal Factors Predictive of Recurrence After Thyroidectomy and Neck Dissection for Papillary Thyroid Carcinoma
Background: Lymph node (LN) yield and ratio are considered important predictors of post-treatment outcomes for several human cancers. This study examined the association between nodal factors, including the LN yield and ratio, with recurrence after thyroidectomy plus central compartment neck dissect...
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| Veröffentlicht in: | Thyroid (New York, N.Y.) N.Y.), 2018-01, Vol.28 (1), p.88-95 |
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| creator | Nam, Sung Hoon Roh, Jong-Lyel Gong, Gyungyup Cho, Kyung-Ja Choi, Seung-Ho Nam, Soon Yuhl Kim, Sang Yoon |
| description | Background:
Lymph node (LN) yield and ratio are considered important predictors of post-treatment outcomes for several human cancers. This study examined the association between nodal factors, including the LN yield and ratio, with recurrence after thyroidectomy plus central compartment neck dissection (ND) for papillary thyroid carcinoma (PTC).
Materials and Methods:
This retrospective study involved 2384 consecutive patients who underwent a thyroidectomy plus central compartment ND combined with (
n
= 440) or without lateral compartment ND at the authors' tertiary referral center between 2006 and 2012. The number of harvested LNs, as well as other tumor and nodal findings, were carefully reviewed. Univariable and multivariable Cox proportional hazards regression models were conducted to predict recurrence and its association with clinicopathologic variables.
Results:
All nodal factors, including the positive number of LNs, ratio, and extranodal extension, were significantly associated with nodal and any-site recurrence after thyroidectomy, as well as the tumor size and multifocality (
p
|
| doi_str_mv | 10.1089/thy.2017.0334 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1962430031</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1962430031</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-da3b75c8d2506e7404dd09ba0a3bdb066cf0a11033b07062a16443da6c998f433</originalsourceid><addsrcrecordid>eNqFkD1PwzAQhi0EouVjZEUeWVLOsWMnIyqfUgUIwRw59kU1JHGxU6T-e1wVWJnu9OrRq7uHkDMGMwZldTkuN7McmJoB52KPTFlRqKwCpfbTDgVkKi_khBzF-A7AZKn4IZnkFWOqLMSUDI_e6o7eajP6EOlzQOvM6L6Q-pa-oFmHgINBetWOGOjrchO8s5jgfkP1YOkjmg967WJMmfMDbX2gz3rluk6HzS9P5zoYN_hen5CDVncRT3_mMXm7vXmd32eLp7uH-dUiMwL4mFnNG1WY0uYFSFQChLVQNRpSbhuQ0rSgGUsvN6BA5ppJIbjV0lRV2QrOj8nFrncV_Oca41j3LhpMVw3o17FmlcwFB-AsodkONcHHGLCtV8H16fqaQb1VXCfF9VZxvVWc-POf6nXTo_2jf50mgO-AbayHoXPYYBj_qf0GyD-JVw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1962430031</pqid></control><display><type>article</type><title>Nodal Factors Predictive of Recurrence After Thyroidectomy and Neck Dissection for Papillary Thyroid Carcinoma</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Nam, Sung Hoon ; Roh, Jong-Lyel ; Gong, Gyungyup ; Cho, Kyung-Ja ; Choi, Seung-Ho ; Nam, Soon Yuhl ; Kim, Sang Yoon</creator><creatorcontrib>Nam, Sung Hoon ; Roh, Jong-Lyel ; Gong, Gyungyup ; Cho, Kyung-Ja ; Choi, Seung-Ho ; Nam, Soon Yuhl ; Kim, Sang Yoon</creatorcontrib><description>Background:
Lymph node (LN) yield and ratio are considered important predictors of post-treatment outcomes for several human cancers. This study examined the association between nodal factors, including the LN yield and ratio, with recurrence after thyroidectomy plus central compartment neck dissection (ND) for papillary thyroid carcinoma (PTC).
Materials and Methods:
This retrospective study involved 2384 consecutive patients who underwent a thyroidectomy plus central compartment ND combined with (
n
= 440) or without lateral compartment ND at the authors' tertiary referral center between 2006 and 2012. The number of harvested LNs, as well as other tumor and nodal findings, were carefully reviewed. Univariable and multivariable Cox proportional hazards regression models were conducted to predict recurrence and its association with clinicopathologic variables.
Results:
All nodal factors, including the positive number of LNs, ratio, and extranodal extension, were significantly associated with nodal and any-site recurrence after thyroidectomy, as well as the tumor size and multifocality (
p
< 0.01). The multivariable analysis showed that tumor size, multifocality, LN ratio, and extranodal extension were independent factors predictive of post-treatment recurrence (
p
< 0.05). The LN yield was higher in patients with nodal recurrence but did not significantly affect the nodal recurrence. Patients with a LN ratio >0.3 exhibited a 1.7-fold higher risk of post-treatment nodal recurrence than their counterparts (
p
< 0.01).
Conclusions:
LN ratio is an independent determinant predictive of nodal and any-site recurrence following thyroidectomy for PTC.</description><identifier>ISSN: 1050-7256</identifier><identifier>EISSN: 1557-9077</identifier><identifier>DOI: 10.1089/thy.2017.0334</identifier><identifier>PMID: 29117854</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Female ; Humans ; Lymphatic Metastasis - pathology ; Male ; Middle Aged ; Neck Dissection ; Neoplasm Recurrence, Local - pathology ; Prognosis ; Retrospective Studies ; Risk Factors ; Thyroid Cancer and Nodules ; Thyroid Cancer, Papillary - pathology ; Thyroid Cancer, Papillary - surgery ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroidectomy ; Treatment Outcome ; Young Adult</subject><ispartof>Thyroid (New York, N.Y.), 2018-01, Vol.28 (1), p.88-95</ispartof><rights>2018, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-da3b75c8d2506e7404dd09ba0a3bdb066cf0a11033b07062a16443da6c998f433</citedby><cites>FETCH-LOGICAL-c403t-da3b75c8d2506e7404dd09ba0a3bdb066cf0a11033b07062a16443da6c998f433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29117854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nam, Sung Hoon</creatorcontrib><creatorcontrib>Roh, Jong-Lyel</creatorcontrib><creatorcontrib>Gong, Gyungyup</creatorcontrib><creatorcontrib>Cho, Kyung-Ja</creatorcontrib><creatorcontrib>Choi, Seung-Ho</creatorcontrib><creatorcontrib>Nam, Soon Yuhl</creatorcontrib><creatorcontrib>Kim, Sang Yoon</creatorcontrib><title>Nodal Factors Predictive of Recurrence After Thyroidectomy and Neck Dissection for Papillary Thyroid Carcinoma</title><title>Thyroid (New York, N.Y.)</title><addtitle>Thyroid</addtitle><description>Background:
Lymph node (LN) yield and ratio are considered important predictors of post-treatment outcomes for several human cancers. This study examined the association between nodal factors, including the LN yield and ratio, with recurrence after thyroidectomy plus central compartment neck dissection (ND) for papillary thyroid carcinoma (PTC).
Materials and Methods:
This retrospective study involved 2384 consecutive patients who underwent a thyroidectomy plus central compartment ND combined with (
n
= 440) or without lateral compartment ND at the authors' tertiary referral center between 2006 and 2012. The number of harvested LNs, as well as other tumor and nodal findings, were carefully reviewed. Univariable and multivariable Cox proportional hazards regression models were conducted to predict recurrence and its association with clinicopathologic variables.
Results:
All nodal factors, including the positive number of LNs, ratio, and extranodal extension, were significantly associated with nodal and any-site recurrence after thyroidectomy, as well as the tumor size and multifocality (
p
< 0.01). The multivariable analysis showed that tumor size, multifocality, LN ratio, and extranodal extension were independent factors predictive of post-treatment recurrence (
p
< 0.05). The LN yield was higher in patients with nodal recurrence but did not significantly affect the nodal recurrence. Patients with a LN ratio >0.3 exhibited a 1.7-fold higher risk of post-treatment nodal recurrence than their counterparts (
p
< 0.01).
Conclusions:
LN ratio is an independent determinant predictive of nodal and any-site recurrence following thyroidectomy for PTC.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Child</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neck Dissection</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Thyroid Cancer and Nodules</subject><subject>Thyroid Cancer, Papillary - pathology</subject><subject>Thyroid Cancer, Papillary - surgery</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>1050-7256</issn><issn>1557-9077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EouVjZEUeWVLOsWMnIyqfUgUIwRw59kU1JHGxU6T-e1wVWJnu9OrRq7uHkDMGMwZldTkuN7McmJoB52KPTFlRqKwCpfbTDgVkKi_khBzF-A7AZKn4IZnkFWOqLMSUDI_e6o7eajP6EOlzQOvM6L6Q-pa-oFmHgINBetWOGOjrchO8s5jgfkP1YOkjmg967WJMmfMDbX2gz3rluk6HzS9P5zoYN_hen5CDVncRT3_mMXm7vXmd32eLp7uH-dUiMwL4mFnNG1WY0uYFSFQChLVQNRpSbhuQ0rSgGUsvN6BA5ppJIbjV0lRV2QrOj8nFrncV_Oca41j3LhpMVw3o17FmlcwFB-AsodkONcHHGLCtV8H16fqaQb1VXCfF9VZxvVWc-POf6nXTo_2jf50mgO-AbayHoXPYYBj_qf0GyD-JVw</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Nam, Sung Hoon</creator><creator>Roh, Jong-Lyel</creator><creator>Gong, Gyungyup</creator><creator>Cho, Kyung-Ja</creator><creator>Choi, Seung-Ho</creator><creator>Nam, Soon Yuhl</creator><creator>Kim, Sang Yoon</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180101</creationdate><title>Nodal Factors Predictive of Recurrence After Thyroidectomy and Neck Dissection for Papillary Thyroid Carcinoma</title><author>Nam, Sung Hoon ; Roh, Jong-Lyel ; Gong, Gyungyup ; Cho, Kyung-Ja ; Choi, Seung-Ho ; Nam, Soon Yuhl ; Kim, Sang Yoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-da3b75c8d2506e7404dd09ba0a3bdb066cf0a11033b07062a16443da6c998f433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Child</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neck Dissection</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Thyroid Cancer and Nodules</topic><topic>Thyroid Cancer, Papillary - pathology</topic><topic>Thyroid Cancer, Papillary - surgery</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nam, Sung Hoon</creatorcontrib><creatorcontrib>Roh, Jong-Lyel</creatorcontrib><creatorcontrib>Gong, Gyungyup</creatorcontrib><creatorcontrib>Cho, Kyung-Ja</creatorcontrib><creatorcontrib>Choi, Seung-Ho</creatorcontrib><creatorcontrib>Nam, Soon Yuhl</creatorcontrib><creatorcontrib>Kim, Sang Yoon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thyroid (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nam, Sung Hoon</au><au>Roh, Jong-Lyel</au><au>Gong, Gyungyup</au><au>Cho, Kyung-Ja</au><au>Choi, Seung-Ho</au><au>Nam, Soon Yuhl</au><au>Kim, Sang Yoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nodal Factors Predictive of Recurrence After Thyroidectomy and Neck Dissection for Papillary Thyroid Carcinoma</atitle><jtitle>Thyroid (New York, N.Y.)</jtitle><addtitle>Thyroid</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>28</volume><issue>1</issue><spage>88</spage><epage>95</epage><pages>88-95</pages><issn>1050-7256</issn><eissn>1557-9077</eissn><abstract>Background:
Lymph node (LN) yield and ratio are considered important predictors of post-treatment outcomes for several human cancers. This study examined the association between nodal factors, including the LN yield and ratio, with recurrence after thyroidectomy plus central compartment neck dissection (ND) for papillary thyroid carcinoma (PTC).
Materials and Methods:
This retrospective study involved 2384 consecutive patients who underwent a thyroidectomy plus central compartment ND combined with (
n
= 440) or without lateral compartment ND at the authors' tertiary referral center between 2006 and 2012. The number of harvested LNs, as well as other tumor and nodal findings, were carefully reviewed. Univariable and multivariable Cox proportional hazards regression models were conducted to predict recurrence and its association with clinicopathologic variables.
Results:
All nodal factors, including the positive number of LNs, ratio, and extranodal extension, were significantly associated with nodal and any-site recurrence after thyroidectomy, as well as the tumor size and multifocality (
p
< 0.01). The multivariable analysis showed that tumor size, multifocality, LN ratio, and extranodal extension were independent factors predictive of post-treatment recurrence (
p
< 0.05). The LN yield was higher in patients with nodal recurrence but did not significantly affect the nodal recurrence. Patients with a LN ratio >0.3 exhibited a 1.7-fold higher risk of post-treatment nodal recurrence than their counterparts (
p
< 0.01).
Conclusions:
LN ratio is an independent determinant predictive of nodal and any-site recurrence following thyroidectomy for PTC.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>29117854</pmid><doi>10.1089/thy.2017.0334</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Child Female Humans Lymphatic Metastasis - pathology Male Middle Aged Neck Dissection Neoplasm Recurrence, Local - pathology Prognosis Retrospective Studies Risk Factors Thyroid Cancer and Nodules Thyroid Cancer, Papillary - pathology Thyroid Cancer, Papillary - surgery Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Thyroidectomy Treatment Outcome Young Adult |
| title | Nodal Factors Predictive of Recurrence After Thyroidectomy and Neck Dissection for Papillary Thyroid Carcinoma |
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