Rheumatoid factor false positivity in patients with ANCA-associated vasculitis not having medical conditions producing rheumatoid factor
We investigated the rate of rheumatoid factor (RF) false positivity at diagnosis and its influence on clinical and prognostic features and rheumatoid arthritis (RA) development during the follow-up in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients without RA or other...
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| Veröffentlicht in: | Clinical rheumatology 2018-10, Vol.37 (10), p.2771-2779 |
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| creator | Moon, Jae-Seung Lee, Diane Da-Hyun Park, Yong-Beom Lee, Sang-Won |
| description | We investigated the rate of rheumatoid factor (RF) false positivity at diagnosis and its influence on clinical and prognostic features and rheumatoid arthritis (RA) development during the follow-up in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients without RA or other medical conditions triggering RF false positivity. We reviewed the medical records of 128 AAV patients. We divided patients with AAV and each variant into two groups according to RF positivity and compared variables between the two groups. Odds ratio and cumulative relapse-free survival rate were obtained by multivariate logistic regression analysis and the Kaplan-Meier survival analysis, respectively. The mean age at diagnosis was 53.6 years and 41 patients were male. Of 128 AAV patients, 69 patients (53.9%) were classified as microscopic polyangiitis (MPA), 29 (22.7%) as granulomatosis with polyangiitis (GPA) and 30 (23.4%) as eosinophilic GPA (EGPA). The rate of RF false positivity was 39.1% in AAV patients. On univariate analysis, general, cutaneous and mucous and ocular manifestations and myeloperoxidase (MPO)-ANCA (or perinuclear (P)-ANCA) positivity were associated with RF false positivity in patients with AAV. On multivariate analysis, cutaneous manifestation was the only independent predictor of RF false positivity in EGPA patients. RF false positivity had no influence on cumulative relapse-free survival rate of AAV or RA development during the follow-up. RF false positivity rate was 39.1% in AAV patients and it was associated with cutaneous manifestation in EGPA patients at diagnosis, but not relapses of AAV or RA development during the follow-up. |
| doi_str_mv | 10.1007/s10067-017-3902-4 |
| format | Article |
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We reviewed the medical records of 128 AAV patients. We divided patients with AAV and each variant into two groups according to RF positivity and compared variables between the two groups. Odds ratio and cumulative relapse-free survival rate were obtained by multivariate logistic regression analysis and the Kaplan-Meier survival analysis, respectively. The mean age at diagnosis was 53.6 years and 41 patients were male. Of 128 AAV patients, 69 patients (53.9%) were classified as microscopic polyangiitis (MPA), 29 (22.7%) as granulomatosis with polyangiitis (GPA) and 30 (23.4%) as eosinophilic GPA (EGPA). The rate of RF false positivity was 39.1% in AAV patients. On univariate analysis, general, cutaneous and mucous and ocular manifestations and myeloperoxidase (MPO)-ANCA (or perinuclear (P)-ANCA) positivity were associated with RF false positivity in patients with AAV. On multivariate analysis, cutaneous manifestation was the only independent predictor of RF false positivity in EGPA patients. RF false positivity had no influence on cumulative relapse-free survival rate of AAV or RA development during the follow-up. RF false positivity rate was 39.1% in AAV patients and it was associated with cutaneous manifestation in EGPA patients at diagnosis, but not relapses of AAV or RA development during the follow-up.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-017-3902-4</identifier><identifier>PMID: 29119480</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - blood ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - diagnosis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - mortality ; Antibodies, Antineutrophil Cytoplasmic ; Antineutrophil cytoplasmic antibodies ; Diagnosis ; Disease-Free Survival ; False Positive Reactions ; Female ; Granulomatosis ; Health risk assessment ; Humans ; Inflammatory diseases ; Kaplan-Meier Estimate ; Leukocytes (eosinophilic) ; Male ; Medical records ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate analysis ; Myeloblastin ; Odds Ratio ; Original Article ; Patients ; Peroxidase ; Retrospective Studies ; Rheumatoid arthritis ; Rheumatoid factor ; Rheumatoid Factor - blood ; Rheumatology ; Survival analysis ; Vasculitis ; Vein & artery diseases</subject><ispartof>Clinical rheumatology, 2018-10, Vol.37 (10), p.2771-2779</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2017</rights><rights>Clinical Rheumatology is a copyright of Springer, (2017). All Rights Reserved.</rights><rights>International League of Associations for Rheumatology (ILAR) 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-56d160fe52d465e6d52473e5ca192304d776b463813a0f73d495d802a85cff6d3</citedby><cites>FETCH-LOGICAL-c400t-56d160fe52d465e6d52473e5ca192304d776b463813a0f73d495d802a85cff6d3</cites><orcidid>0000-0002-8038-3341</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-017-3902-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-017-3902-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29119480$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moon, Jae-Seung</creatorcontrib><creatorcontrib>Lee, Diane Da-Hyun</creatorcontrib><creatorcontrib>Park, Yong-Beom</creatorcontrib><creatorcontrib>Lee, Sang-Won</creatorcontrib><title>Rheumatoid factor false positivity in patients with ANCA-associated vasculitis not having medical conditions producing rheumatoid factor</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>We investigated the rate of rheumatoid factor (RF) false positivity at diagnosis and its influence on clinical and prognostic features and rheumatoid arthritis (RA) development during the follow-up in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients without RA or other medical conditions triggering RF false positivity. We reviewed the medical records of 128 AAV patients. We divided patients with AAV and each variant into two groups according to RF positivity and compared variables between the two groups. Odds ratio and cumulative relapse-free survival rate were obtained by multivariate logistic regression analysis and the Kaplan-Meier survival analysis, respectively. The mean age at diagnosis was 53.6 years and 41 patients were male. Of 128 AAV patients, 69 patients (53.9%) were classified as microscopic polyangiitis (MPA), 29 (22.7%) as granulomatosis with polyangiitis (GPA) and 30 (23.4%) as eosinophilic GPA (EGPA). The rate of RF false positivity was 39.1% in AAV patients. On univariate analysis, general, cutaneous and mucous and ocular manifestations and myeloperoxidase (MPO)-ANCA (or perinuclear (P)-ANCA) positivity were associated with RF false positivity in patients with AAV. On multivariate analysis, cutaneous manifestation was the only independent predictor of RF false positivity in EGPA patients. RF false positivity had no influence on cumulative relapse-free survival rate of AAV or RA development during the follow-up. RF false positivity rate was 39.1% in AAV patients and it was associated with cutaneous manifestation in EGPA patients at diagnosis, but not relapses of AAV or RA development during the follow-up.</description><subject>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - blood</subject><subject>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - diagnosis</subject><subject>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - mortality</subject><subject>Antibodies, Antineutrophil Cytoplasmic</subject><subject>Antineutrophil cytoplasmic antibodies</subject><subject>Diagnosis</subject><subject>Disease-Free Survival</subject><subject>False Positive Reactions</subject><subject>Female</subject><subject>Granulomatosis</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Inflammatory diseases</subject><subject>Kaplan-Meier Estimate</subject><subject>Leukocytes (eosinophilic)</subject><subject>Male</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Myeloblastin</subject><subject>Odds Ratio</subject><subject>Original Article</subject><subject>Patients</subject><subject>Peroxidase</subject><subject>Retrospective Studies</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid factor</subject><subject>Rheumatoid Factor - blood</subject><subject>Rheumatology</subject><subject>Survival analysis</subject><subject>Vasculitis</subject><subject>Vein & artery diseases</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUFvVCEUhYnR2HH0B7gxJG7cYC88HjyWk4lWk8Ympl0TCrwOzRsYgTdN_4E_W6ZTNWmiG-7ifPecGw5Cbyl8pADytLRXSAJUkk4BI_wZWlDecaIUV8_RAqQE0lE1nKBXpdwCABsUfYlOmKJU8QEW6Of3jZ-3pqbg8GhsTbmNqXi8SyXUsA_1HoeId6YGH2vBd6Fu8OrbekVMKckGU73De1PsPDW84Jgq3ph9iDd4612wZsI2Rde0FAve5eRmexDz09jX6MVD8JvHuURXnz9drr-Q84uzr-vVObEcoJJeOCpg9D1zXPReuJ5x2fneGqpYB9xJKa656AbaGRhl57jq3QDMDL0dR-G6Jfpw9G23_Jh9qXobivXTZKJPc9FUCcaZoM11id4_QW_TnGO7TjOhuJSswf-lKDAOnFHaKHqkbE6lZD_qXQ5bk-81BX0oUx_L1K1MfShT87bz7tF5vm6f-Wfjd3sNYEegNCne-Pw3-t-uvwCmcqqP</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Moon, Jae-Seung</creator><creator>Lee, Diane Da-Hyun</creator><creator>Park, Yong-Beom</creator><creator>Lee, Sang-Won</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8038-3341</orcidid></search><sort><creationdate>20181001</creationdate><title>Rheumatoid factor false positivity in patients with ANCA-associated vasculitis not having medical conditions producing rheumatoid factor</title><author>Moon, Jae-Seung ; Lee, Diane Da-Hyun ; Park, Yong-Beom ; Lee, Sang-Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-56d160fe52d465e6d52473e5ca192304d776b463813a0f73d495d802a85cff6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - blood</topic><topic>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - diagnosis</topic><topic>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - mortality</topic><topic>Antibodies, Antineutrophil Cytoplasmic</topic><topic>Antineutrophil cytoplasmic antibodies</topic><topic>Diagnosis</topic><topic>Disease-Free Survival</topic><topic>False Positive Reactions</topic><topic>Female</topic><topic>Granulomatosis</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Inflammatory diseases</topic><topic>Kaplan-Meier Estimate</topic><topic>Leukocytes (eosinophilic)</topic><topic>Male</topic><topic>Medical records</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Myeloblastin</topic><topic>Odds Ratio</topic><topic>Original Article</topic><topic>Patients</topic><topic>Peroxidase</topic><topic>Retrospective Studies</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid factor</topic><topic>Rheumatoid Factor - blood</topic><topic>Rheumatology</topic><topic>Survival analysis</topic><topic>Vasculitis</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moon, Jae-Seung</creatorcontrib><creatorcontrib>Lee, Diane Da-Hyun</creatorcontrib><creatorcontrib>Park, Yong-Beom</creatorcontrib><creatorcontrib>Lee, Sang-Won</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moon, Jae-Seung</au><au>Lee, Diane Da-Hyun</au><au>Park, Yong-Beom</au><au>Lee, Sang-Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rheumatoid factor false positivity in patients with ANCA-associated vasculitis not having medical conditions producing rheumatoid factor</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>37</volume><issue>10</issue><spage>2771</spage><epage>2779</epage><pages>2771-2779</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>We investigated the rate of rheumatoid factor (RF) false positivity at diagnosis and its influence on clinical and prognostic features and rheumatoid arthritis (RA) development during the follow-up in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients without RA or other medical conditions triggering RF false positivity. We reviewed the medical records of 128 AAV patients. We divided patients with AAV and each variant into two groups according to RF positivity and compared variables between the two groups. Odds ratio and cumulative relapse-free survival rate were obtained by multivariate logistic regression analysis and the Kaplan-Meier survival analysis, respectively. The mean age at diagnosis was 53.6 years and 41 patients were male. Of 128 AAV patients, 69 patients (53.9%) were classified as microscopic polyangiitis (MPA), 29 (22.7%) as granulomatosis with polyangiitis (GPA) and 30 (23.4%) as eosinophilic GPA (EGPA). The rate of RF false positivity was 39.1% in AAV patients. On univariate analysis, general, cutaneous and mucous and ocular manifestations and myeloperoxidase (MPO)-ANCA (or perinuclear (P)-ANCA) positivity were associated with RF false positivity in patients with AAV. On multivariate analysis, cutaneous manifestation was the only independent predictor of RF false positivity in EGPA patients. RF false positivity had no influence on cumulative relapse-free survival rate of AAV or RA development during the follow-up. RF false positivity rate was 39.1% in AAV patients and it was associated with cutaneous manifestation in EGPA patients at diagnosis, but not relapses of AAV or RA development during the follow-up.</abstract><cop>London</cop><pub>Springer London</pub><pmid>29119480</pmid><doi>10.1007/s10067-017-3902-4</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8038-3341</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - blood Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - diagnosis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - mortality Antibodies, Antineutrophil Cytoplasmic Antineutrophil cytoplasmic antibodies Diagnosis Disease-Free Survival False Positive Reactions Female Granulomatosis Health risk assessment Humans Inflammatory diseases Kaplan-Meier Estimate Leukocytes (eosinophilic) Male Medical records Medicine Medicine & Public Health Middle Aged Multivariate analysis Myeloblastin Odds Ratio Original Article Patients Peroxidase Retrospective Studies Rheumatoid arthritis Rheumatoid factor Rheumatoid Factor - blood Rheumatology Survival analysis Vasculitis Vein & artery diseases |
| title | Rheumatoid factor false positivity in patients with ANCA-associated vasculitis not having medical conditions producing rheumatoid factor |
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