Involvement of calpain in AMPA-induced toxicity to rat cerebellar Purkinje neurons

AMPA receptor-elicited excitotoxicity is manifested as both a type of programmed cell death termed dark cell degeneration and edematous necrosis, both of which are linked to increased intracellular Ca 2+ concentration. The appearance of marked cytoskeletal changes in response to abusive AMPA recepto...

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Veröffentlicht in:	European journal of pharmacology 2007-02, Vol.557 (2), p.106-114
Hauptverfasser:	Mansouri, Bobbak, Henne, William M., Oomman, Sowmini K., Bliss, Richard, Attridge, Jennifer, Finckbone, VelvetLee, Zeitouni, Tarek, Hoffman, Trent, Bahr, Ben A., Strahlendorf, Howard K., Strahlendorf, Jean C.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - toxicity AMPA Animals Biological and medical sciences Calpain Calpain - metabolism Cell Death Cerebellum Cerebellum - drug effects Cerebellum - pathology Excitatory Amino Acid Agonists - toxicity Female Histocytochemistry Immunohistochemistry Male Medical sciences Neuronal death Neurons - drug effects Neurons - pathology Pharmacology. Drug treatments Purkinje Cells - drug effects Purkinje Cells - pathology Rats Rats, Sprague-Dawley α-Spectrin
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