Frontline therapy of acute promyelocytic leukemia: Randomized comparison of ATRA and intensified chemotherapy versus ATRA and anthracyclines

Objectives Randomized comparison of two treatment strategies in frontline therapy of acute promyelocytic leukemia (APL): all‐trans retinoic acid (ATRA) and double induction intensified by high‐dose cytosine arabinoside (HD ara‐C) (German AMLCG) and therapy with ATRA and anthracyclines (Spanish PETHE...

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Veröffentlicht in:	European journal of haematology 2018-02, Vol.100 (2), p.154-162
Hauptverfasser:	Lengfelder, Eva, Görlich, Dennis, Nowak, Daniel, Spiekermann, Karsten, Haferlach, Claudia, Krug, Utz, Kreuzer, Karl‐Anton, Braess, Jan, Schliemann, Christoph, Lindemann, Hans‐Walter, Horst, Heinz A., Schiel, Xaver, Flasshove, Michael, Hecht, Anna, Schnittger, Susanne, Schneider, Stephanie, Wörmann, Bernhard, Hofmann, Wolf‐Karsten, Berdel, Wolfgang E., Bormann, Eike, Sauerland, Cristina, Büchner, Thomas, Hiddemann, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	acute promyelocytic leukemia Acute promyeloid leukemia Adult Aged Aged, 80 and over Anthracycline Anthracyclines - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers Chemotherapy Consolidation Chemotherapy Cytarabine Cytarabine - administration & dosage Cytogenetic Analysis Cytosine early death Female high‐dose cytosine arabinoside high‐risk APL Humans Leukemia Leukemia, Promyelocytic, Acute - diagnosis Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - mortality Male Middle Aged minimal residual disease Neoplasm, Residual - pathology Neutropenia Polymerase chain reaction Promyeloid leukemia Recurrence relapse Remission Remission Induction Retinoic acid Risk groups Survival Survival Analysis Treatment Outcome Tretinoin - administration & dosage Young Adult
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