Doxorubicin encapsulated clicked gold nanoparticle clusters exhibiting tumor-specific disassembly for enhanced tumor localization and computerized tomographic imaging

Gold nanoparticles (AuNPs) and matrix metalloproteinase (MMP)-2 cleavable peptides are clicked into gold nanoparticle clusters (AuNCs) for enhanced drug localization and micro computerized tomography (μCT) theranostic of tumors. AuNPs are co-functionalized with doxorubicin (DOX) and an azide-termina...

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Veröffentlicht in:	Journal of controlled release 2018-01, Vol.269, p.52-62
Hauptverfasser:	Mao, Wei, Kim, Hye Sung, Son, Young Ju, Kim, Song Rae, Yoo, Hyuk Sang
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer therapy Click chemistry Enhanced permeability and retention effect Gold nanoparticle clusters Micro computerized topography
Online-Zugang:	Volltext
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