Novel histidine-conjugated galactosylated cationic liposomes for efficient hepatocyte-selective gene transfer in human hepatoma HepG2 cells

To enhance gene transfection to hepatocytes by cationic liposomes, it is necessary to overcome a number of barriers existing in the process from administration to gene expression. Recently we and other group have demonstrated that the escape of plasmid DNA (pDNA)/cationic liposome complexes (lipople...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of controlled release 2007-04, Vol.118 (2), p.262-270
Hauptverfasser:	Shigeta, Kosuke, Kawakami, Shigeru, Higuchi, Yuriko, Okuda, Tatsuya, Yagi, Hiroko, Yamashita, Fumiyoshi, Hashida, Mitsuru
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Asialoglycoprotein Receptor - metabolism Biological and medical sciences Carcinoma, Hepatocellular - metabolism Cations Cell Line, Tumor Cell Nucleus - metabolism Cell Survival - drug effects Cholestenes - metabolism Cholesterol Esters - chemistry Cholesterol Esters - metabolism Cholesterol Esters - toxicity Cytoplasm - metabolism DNA - chemistry DNA - metabolism Endosomes - metabolism Galactosylated liposomes Gene therapy General pharmacology Genes, Reporter Glycopeptides - chemistry Glycopeptides - metabolism Glycopeptides - toxicity Hepatocytes Histidine Humans Hydrogen-Ion Concentration Liposomes Liver Neoplasms - metabolism Luciferases Mannitol - metabolism Medical sciences Mice NIH 3T3 Cells Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Proton sponge effect Transfection - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!