Lipoplex morphologies and their influences on transfection efficiency in gene delivery

Cationic lipid-mediated gene transfer is widely used for their advantages over viral gene transfer because it is non-immunogenic, easy to produce and not oncogenic. The main drawback of the application of cationic lipids is their low transfection efficiency. Many reports about transfection efficienc...

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Veröffentlicht in:	Journal of controlled release 2007-11, Vol.123 (3), p.184-194
Hauptverfasser:	Ma, Baichao, Zhang, Shubiao, Jiang, Huiming, Zhao, Budiao, Lv, Hongtao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cationic lipoplexes Cations Cell Membrane - metabolism DNA - chemistry DNA - metabolism Endocytosis Gene delivery General pharmacology Genetic Therapy - methods Humans Lipid Metabolism Lipids - chemistry Lipids - toxicity Lipoplex morphology Liposomes Medical sciences Membrane Fusion Molecular Conformation Nucleic Acid Conformation Osmolar Concentration Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Serum - metabolism Temperature Transfection Transfection efficiency
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