Lipoplex morphologies and their influences on transfection efficiency in gene delivery
Cationic lipid-mediated gene transfer is widely used for their advantages over viral gene transfer because it is non-immunogenic, easy to produce and not oncogenic. The main drawback of the application of cationic lipids is their low transfection efficiency. Many reports about transfection efficienc...
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| Veröffentlicht in: | Journal of controlled release 2007-11, Vol.123 (3), p.184-194 |
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| creator | Ma, Baichao Zhang, Shubiao Jiang, Huiming Zhao, Budiao Lv, Hongtao |
| description | Cationic lipid-mediated gene transfer is widely used for their advantages over viral gene transfer because it is non-immunogenic, easy to produce and not oncogenic. The main drawback of the application of cationic lipids is their low transfection efficiency. Many reports about transfection efficiency of cationic lipids have been published in recent years. In this review, the current status and prospects for transfection efficiency of different morphologies of lipoplexes are discussed. High transfection activity will be acquired for H
C
II structure when membrane fusion is dominant, but when serum is present L
C
α lipoplexes show great superiority for their inhibition dissociation by serum during lipoplexes transporting. Increasing DOPE often gains high activity for the H
C
II structure promoted by DOPE. High lipofection will be gained from large lipoplexes when endocytosis is dominant, because large particles facilitate membrane contact and fusion. We suggest morphologies of lipoplex should be characterized at two levels, lipoplex size and self-assemble structures of lipoplexes, and understanding these would be very important for scientists to prepare novel cationic lipids and design novel formulations with high transfection efficiency. |
| doi_str_mv | 10.1016/j.jconrel.2007.08.022 |
| format | Article |
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C
II structure when membrane fusion is dominant, but when serum is present L
C
α lipoplexes show great superiority for their inhibition dissociation by serum during lipoplexes transporting. Increasing DOPE often gains high activity for the H
C
II structure promoted by DOPE. High lipofection will be gained from large lipoplexes when endocytosis is dominant, because large particles facilitate membrane contact and fusion. We suggest morphologies of lipoplex should be characterized at two levels, lipoplex size and self-assemble structures of lipoplexes, and understanding these would be very important for scientists to prepare novel cationic lipids and design novel formulations with high transfection efficiency.</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2007.08.022</identifier><identifier>PMID: 17913276</identifier><identifier>CODEN: JCREEC</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Cationic lipoplexes ; Cations ; Cell Membrane - metabolism ; DNA - chemistry ; DNA - metabolism ; Endocytosis ; Gene delivery ; General pharmacology ; Genetic Therapy - methods ; Humans ; Lipid Metabolism ; Lipids - chemistry ; Lipids - toxicity ; Lipoplex morphology ; Liposomes ; Medical sciences ; Membrane Fusion ; Molecular Conformation ; Nucleic Acid Conformation ; Osmolar Concentration ; Particle Size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Serum - metabolism ; Temperature ; Transfection ; Transfection efficiency</subject><ispartof>Journal of controlled release, 2007-11, Vol.123 (3), p.184-194</ispartof><rights>2007 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-89f3741acfbe1ebcb1bb934e6c2da2a4b5150e4b6fb42918f39eae1ad7ac29643</citedby><cites>FETCH-LOGICAL-c424t-89f3741acfbe1ebcb1bb934e6c2da2a4b5150e4b6fb42918f39eae1ad7ac29643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jconrel.2007.08.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19220005$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17913276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Baichao</creatorcontrib><creatorcontrib>Zhang, Shubiao</creatorcontrib><creatorcontrib>Jiang, Huiming</creatorcontrib><creatorcontrib>Zhao, Budiao</creatorcontrib><creatorcontrib>Lv, Hongtao</creatorcontrib><title>Lipoplex morphologies and their influences on transfection efficiency in gene delivery</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>Cationic lipid-mediated gene transfer is widely used for their advantages over viral gene transfer because it is non-immunogenic, easy to produce and not oncogenic. The main drawback of the application of cationic lipids is their low transfection efficiency. Many reports about transfection efficiency of cationic lipids have been published in recent years. In this review, the current status and prospects for transfection efficiency of different morphologies of lipoplexes are discussed. High transfection activity will be acquired for H
C
II structure when membrane fusion is dominant, but when serum is present L
C
α lipoplexes show great superiority for their inhibition dissociation by serum during lipoplexes transporting. Increasing DOPE often gains high activity for the H
C
II structure promoted by DOPE. High lipofection will be gained from large lipoplexes when endocytosis is dominant, because large particles facilitate membrane contact and fusion. We suggest morphologies of lipoplex should be characterized at two levels, lipoplex size and self-assemble structures of lipoplexes, and understanding these would be very important for scientists to prepare novel cationic lipids and design novel formulations with high transfection efficiency.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cationic lipoplexes</subject><subject>Cations</subject><subject>Cell Membrane - metabolism</subject><subject>DNA - chemistry</subject><subject>DNA - metabolism</subject><subject>Endocytosis</subject><subject>Gene delivery</subject><subject>General pharmacology</subject><subject>Genetic Therapy - methods</subject><subject>Humans</subject><subject>Lipid Metabolism</subject><subject>Lipids - chemistry</subject><subject>Lipids - toxicity</subject><subject>Lipoplex morphology</subject><subject>Liposomes</subject><subject>Medical sciences</subject><subject>Membrane Fusion</subject><subject>Molecular Conformation</subject><subject>Nucleic Acid Conformation</subject><subject>Osmolar Concentration</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Serum - metabolism</subject><subject>Temperature</subject><subject>Transfection</subject><subject>Transfection efficiency</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1v2yAYwHFUrWqyrB-hky_bzS5gbMxpmqq9VIrUS7srAvzQYBHjgVM13760sdRjTwj486IfQlcEVwST9nqoBhPGCL6iGPMKdxWm9AytScfrkgnRfELr3HVl3TZihT6nNGCMm5rxC7QiXJCa8naN_m3dFCYPz8U-xGkXfHh0kAo19sW8AxcLN1p_gNHkxTAWc1RjsmBmlydgrTMu7x1zVTzCCEUP3j1BPH5B51b5BJfLuEEPv3_d3_wtt3d_bm9-bkvDKJvLTtiaM6KM1UBAG020FjWD1tBeUcV0QxoMTLdWMypIZ2sBCojquTJUtKzeoO-ne6cY_h8gzXLvkgHv1QjhkCQRLeFcNDlsTqGJIaUIVk7R7VU8SoLlK6gc5AIqX0El7mQGzee-Lg8c9B7691OLYA6-LYFKRnmbgYxL752g9M19g36cOsgcTw6iTG920LuYPWUf3AdfeQEEg5j-</recordid><startdate>20071120</startdate><enddate>20071120</enddate><creator>Ma, Baichao</creator><creator>Zhang, Shubiao</creator><creator>Jiang, Huiming</creator><creator>Zhao, Budiao</creator><creator>Lv, Hongtao</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20071120</creationdate><title>Lipoplex morphologies and their influences on transfection efficiency in gene delivery</title><author>Ma, Baichao ; Zhang, Shubiao ; Jiang, Huiming ; Zhao, Budiao ; Lv, Hongtao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-89f3741acfbe1ebcb1bb934e6c2da2a4b5150e4b6fb42918f39eae1ad7ac29643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cationic lipoplexes</topic><topic>Cations</topic><topic>Cell Membrane - metabolism</topic><topic>DNA - chemistry</topic><topic>DNA - metabolism</topic><topic>Endocytosis</topic><topic>Gene delivery</topic><topic>General pharmacology</topic><topic>Genetic Therapy - methods</topic><topic>Humans</topic><topic>Lipid Metabolism</topic><topic>Lipids - chemistry</topic><topic>Lipids - toxicity</topic><topic>Lipoplex morphology</topic><topic>Liposomes</topic><topic>Medical sciences</topic><topic>Membrane Fusion</topic><topic>Molecular Conformation</topic><topic>Nucleic Acid Conformation</topic><topic>Osmolar Concentration</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Serum - metabolism</topic><topic>Temperature</topic><topic>Transfection</topic><topic>Transfection efficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Baichao</creatorcontrib><creatorcontrib>Zhang, Shubiao</creatorcontrib><creatorcontrib>Jiang, Huiming</creatorcontrib><creatorcontrib>Zhao, Budiao</creatorcontrib><creatorcontrib>Lv, Hongtao</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Baichao</au><au>Zhang, Shubiao</au><au>Jiang, Huiming</au><au>Zhao, Budiao</au><au>Lv, Hongtao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipoplex morphologies and their influences on transfection efficiency in gene delivery</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2007-11-20</date><risdate>2007</risdate><volume>123</volume><issue>3</issue><spage>184</spage><epage>194</epage><pages>184-194</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>Cationic lipid-mediated gene transfer is widely used for their advantages over viral gene transfer because it is non-immunogenic, easy to produce and not oncogenic. The main drawback of the application of cationic lipids is their low transfection efficiency. Many reports about transfection efficiency of cationic lipids have been published in recent years. In this review, the current status and prospects for transfection efficiency of different morphologies of lipoplexes are discussed. High transfection activity will be acquired for H
C
II structure when membrane fusion is dominant, but when serum is present L
C
α lipoplexes show great superiority for their inhibition dissociation by serum during lipoplexes transporting. Increasing DOPE often gains high activity for the H
C
II structure promoted by DOPE. High lipofection will be gained from large lipoplexes when endocytosis is dominant, because large particles facilitate membrane contact and fusion. We suggest morphologies of lipoplex should be characterized at two levels, lipoplex size and self-assemble structures of lipoplexes, and understanding these would be very important for scientists to prepare novel cationic lipids and design novel formulations with high transfection efficiency.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17913276</pmid><doi>10.1016/j.jconrel.2007.08.022</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Cationic lipoplexes Cations Cell Membrane - metabolism DNA - chemistry DNA - metabolism Endocytosis Gene delivery General pharmacology Genetic Therapy - methods Humans Lipid Metabolism Lipids - chemistry Lipids - toxicity Lipoplex morphology Liposomes Medical sciences Membrane Fusion Molecular Conformation Nucleic Acid Conformation Osmolar Concentration Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Serum - metabolism Temperature Transfection Transfection efficiency |
| title | Lipoplex morphologies and their influences on transfection efficiency in gene delivery |
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