Oxidative stress induces renal failure: A review of possible molecular pathways
It has been reported that oxidative stress has a pivotal role in many disorders such as chronic kidney diseases. Free radicals can directly attack cellular elements, trigger intracellular signaling pathways, or induce systemic responses leading to renal damages. In the current review, we evaluated t...
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| Veröffentlicht in: | Journal of cellular biochemistry 2018-04, Vol.119 (4), p.2990-2998 |
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| container_title | Journal of cellular biochemistry |
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| creator | Yaribeygi, Habib Farrokhi, Farin R. Rezaee, Ramin Sahebkar, Amirhossein |
| description | It has been reported that oxidative stress has a pivotal role in many disorders such as chronic kidney diseases. Free radicals can directly attack cellular elements, trigger intracellular signaling pathways, or induce systemic responses leading to renal damages. In the current review, we evaluated the literature focusing on the main recognized effects of oxidative stress on the pathophysiology of chronic renal disorders. We searched the PubMed‐Medline and Scopus databases by using the following key words: oxidative stress, kidney, chronic kidney diseases, and free radicals and found about 200 related articles. Then, we focused on the molecular mechanisms underlying chronic kidney diseases which can be induced by oxidative stress and explored how free radicals stimulate these mechanisms. By reviewing the literature, we found that there are almost nine important molecular pathways through which free radicals influence the renal function. Based on the retrieved data, oxidative stress has an important role in the pathophysiology of chronic kidney diseases. Understanding these pathophysiologic pathways may lead us to find new approaches for the management of these debilitating disorders.
In the current review, we evaluated the literature focusing on the main recognized effects of oxidative stress on the pathophysiology of chronic renal disorders. |
| doi_str_mv | 10.1002/jcb.26450 |
| format | Article |
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In the current review, we evaluated the literature focusing on the main recognized effects of oxidative stress on the pathophysiology of chronic renal disorders.</description><subject>chronic kidney disease</subject><subject>Damage assessment</subject><subject>Diseases</subject><subject>Disorders</subject><subject>Free radicals</subject><subject>Intracellular signalling</subject><subject>kidney</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Literature reviews</subject><subject>Molecular modelling</subject><subject>Oxidative stress</subject><subject>Renal failure</subject><subject>Renal function</subject><issn>0730-2312</issn><issn>1097-4644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kE1rGzEQQEVpSdw0h_yBIuilOTiZkbSSlVti0i8CvuQutNIslZG9ruS163_fTZ30EOhpYHg8Zh5jFwhXCCCul6G9Elo18IZNEKyZKq3UWzYBI2EqJIpT9r7WJQBYK8UJOxUWERujJ2yx-J2i36Yd8botVCtP6zgEqrzQ2mfe-ZSHQjf8dlzsEu153_FNX2tqM_FVnykM2Re-8dufe3-oH9i7zudK58_zjD1-uX-cf5s-LL5-n98-TINsxqOkn0nbEERUnRGtRRNip5QCpdvGQwCpTdvKFpXvUEZtUc5MYyma0MUY5Bn7fNRuSv9roLp1q1QD5ezX1A_VodWolbDajOinV-iyH8r4W3UCYAYoND5Rl0cqlPG5Qp3blLTy5eAQ3FNkN0Z2fyOP7Mdn49CuKP4jX6qOwPUR2KdMh_-b3I_53VH5B4YIhOg</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Yaribeygi, Habib</creator><creator>Farrokhi, Farin R.</creator><creator>Rezaee, Ramin</creator><creator>Sahebkar, Amirhossein</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8656-1444</orcidid></search><sort><creationdate>201804</creationdate><title>Oxidative stress induces renal failure: A review of possible molecular pathways</title><author>Yaribeygi, Habib ; Farrokhi, Farin R. ; Rezaee, Ramin ; Sahebkar, Amirhossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3530-3a8395e0d14f72b917cdf444046b5a0c0367bb3b14af13d69138759ed7cfddc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>chronic kidney disease</topic><topic>Damage assessment</topic><topic>Diseases</topic><topic>Disorders</topic><topic>Free radicals</topic><topic>Intracellular signalling</topic><topic>kidney</topic><topic>Kidney diseases</topic><topic>Kidneys</topic><topic>Literature reviews</topic><topic>Molecular modelling</topic><topic>Oxidative stress</topic><topic>Renal failure</topic><topic>Renal function</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yaribeygi, Habib</creatorcontrib><creatorcontrib>Farrokhi, Farin R.</creatorcontrib><creatorcontrib>Rezaee, Ramin</creatorcontrib><creatorcontrib>Sahebkar, Amirhossein</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yaribeygi, Habib</au><au>Farrokhi, Farin R.</au><au>Rezaee, Ramin</au><au>Sahebkar, Amirhossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative stress induces renal failure: A review of possible molecular pathways</atitle><jtitle>Journal of cellular biochemistry</jtitle><addtitle>J Cell Biochem</addtitle><date>2018-04</date><risdate>2018</risdate><volume>119</volume><issue>4</issue><spage>2990</spage><epage>2998</epage><pages>2990-2998</pages><issn>0730-2312</issn><eissn>1097-4644</eissn><abstract>It has been reported that oxidative stress has a pivotal role in many disorders such as chronic kidney diseases. Free radicals can directly attack cellular elements, trigger intracellular signaling pathways, or induce systemic responses leading to renal damages. In the current review, we evaluated the literature focusing on the main recognized effects of oxidative stress on the pathophysiology of chronic renal disorders. We searched the PubMed‐Medline and Scopus databases by using the following key words: oxidative stress, kidney, chronic kidney diseases, and free radicals and found about 200 related articles. Then, we focused on the molecular mechanisms underlying chronic kidney diseases which can be induced by oxidative stress and explored how free radicals stimulate these mechanisms. By reviewing the literature, we found that there are almost nine important molecular pathways through which free radicals influence the renal function. Based on the retrieved data, oxidative stress has an important role in the pathophysiology of chronic kidney diseases. Understanding these pathophysiologic pathways may lead us to find new approaches for the management of these debilitating disorders.
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | chronic kidney disease Damage assessment Diseases Disorders Free radicals Intracellular signalling kidney Kidney diseases Kidneys Literature reviews Molecular modelling Oxidative stress Renal failure Renal function |
| title | Oxidative stress induces renal failure: A review of possible molecular pathways |
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