Development and Function of the Mucosal Immune System in the Upper Respiratory Tract of Neonatal Calves
Respiratory infections remain the second most common cause of clinical disease and mortality in newborn calves, which has led to increased interest in using vaccines early in life to mitigate this risk. Intranasal vaccination of neonatal calves can be an effective strategy to circumvent vaccine inte...
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| Veröffentlicht in: | Annual review of animal biosciences 2018-02, Vol.6 (1), p.141-155 |
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| container_title | Annual review of animal biosciences |
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| creator | Osman, Rahwa Malmuthuge, Nilusha Gonzalez-Cano, Patricia Griebel, Philip |
| description | Respiratory infections remain the second most common cause of clinical disease and mortality in newborn calves, which has led to increased interest in using vaccines early in life to mitigate this risk. Intranasal vaccination of neonatal calves can be an effective strategy to circumvent vaccine interference by maternal antibody, but this raises questions regarding onset of immune competence in the upper respiratory tract (URT) following birth. Little is known, however, about the development and function of mucosa-associated lymphoid tissue (MALT) in the URT of newborn calves and what factors, including the commensal microbiome, contribute to this early development. We review the structure, development, and function of MALT in the bovine URT during the first six weeks of life and identify knowledge gaps regarding this early developmental time. This information is critical when designing vaccination programs for young calves, especially when targeting respiratory pathogens that may reside within the commensal microbiome. |
| doi_str_mv | 10.1146/annurev-animal-030117-014611 |
| format | Article |
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| ispartof | Annual review of animal biosciences, 2018-02, Vol.6 (1), p.141-155 |
| issn | 2165-8102 2165-8110 |
| language | eng |
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| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Animals Animals, Newborn - immunology Animals, Newborn - microbiology bovine Cattle - growth & development Cattle - immunology Cattle - microbiology Cattle Diseases - microbiology Cattle Diseases - prevention & control IgA Immunity, Mucosal immunoglobulin A microbiome mucosa-associated lymphoid tissue Respiratory Mucosa - immunology Respiratory Mucosa - microbiology vaccine |
| title | Development and Function of the Mucosal Immune System in the Upper Respiratory Tract of Neonatal Calves |
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