Histological transformation after acquired resistance to epidermal growth factor tyrosine kinase inhibitors

Non-small-cell lung cancer patients with sensitive epidermal growth factor receptor mutations generally respond well to tyrosine kinase inhibitors (TKIs). However, acquired resistance will eventually develop place after 8–16 months. Several mechanisms contribute to the resistance including T790M mut...

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Veröffentlicht in:	International journal of clinical oncology 2018-04, Vol.23 (2), p.235-242
Hauptverfasser:	Shao, Yi, Zhong, Dian-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopsy c-Met protein Cancer Research Case reports Drug resistance Epidermal growth factor Genetic transformation Histology Inhibitor drugs Kinases Lung cancer Lung carcinoma Medical research Medicine Medicine & Public Health Mesenchyme Mutation Neuroendocrine tumors Oncology Patients Review Article Sarcoma Squamous cell carcinoma Stem cells Surgical Oncology Tyrosine kinase inhibitors
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