EphA2 Targeted Doxorubicin-Nanoliposomes for Osteosarcoma Treatment

ABSTRACT Purpose To employ Doxorubicin-loaded liposomes, modified with YSA-peptide to target EphA2, to reduce adverse effects against primary bone cells and maximize toxicity against Saos-2 osteosarcoma cells. Methods PEGylated liposomes were prepared by thin film method using Dipalmitoylphosphatidy...

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Veröffentlicht in:	Pharmaceutical research 2017-12, Vol.34 (12), p.2891-2900
Hauptverfasser:	Haghiralsadat, Fateme, Amoabediny, Ghasem, Naderinezhad, Samira, Nazmi, Kamran, De Boer, Jantine Posthuma, Zandieh-Doulabi, Behrouz, Forouzanfar, Tymour, Helder, Marco N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - pharmacology Antimitotic agents Antineoplastic agents Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Bone cancer Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Cell Line, Tumor Cholesterol Cytotoxicity Doxorubicin Doxorubicin - administration & dosage Doxorubicin - analogs & derivatives Doxorubicin - pharmacology Drug Delivery Systems EphA2 protein Formulations Humans Kinetics Liposomes Liposomes - chemistry Mechanical loading Medical Law MPEG encoders Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - metabolism Osteosarcoma cells Peptides Peptides - chemistry pH effects Pharmacology/Toxicology Pharmacy Polydispersity Polyethylene glycol Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Receptor, EphA2 - metabolism Research Paper Sarcoma Toxicity Toxicity testing Zeta potential
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