Investigation of the pronounced erythropoietin-induced reduction in hyperglycemia in type 1-like diabetic rats

Erythropoietin (EPO) is known to stimulate erythropoiesis after binding with its specific receptor. In clinics, EPO is widely used in hemodialyzed patients with diabetes. However, changes in the expression of the erythropoietin receptor (EPOR) under diabetic conditions are still unclear. Therefore,...

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Veröffentlicht in:	ENDOCRINE JOURNAL 2018, Vol.65(2), pp.181-191
Hauptverfasser:	Kuo, Shu-Chun, Li, Yingxiao, Cheng, Kai-Chun, Niu, Chiang-Shan, Cheng, Juei-Tang, Niu, Ho-Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - drug effects Blood Glucose - metabolism Cells, Cultured Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 1 - chemically induced Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - physiopathology Erythropoiesis Erythropoiesis - drug effects Erythropoietin Erythropoietin - therapeutic use Erythropoietin receptor Glucose Hyperglycemia Hyperglycemia - etiology Hyperglycemia - prevention & control Investigations Male Rats Rats, Wistar Receptors, Erythropoietin - genetics Receptors, Erythropoietin - metabolism Rodents siRNA Soleus muscle Stat3 protein Streptozocin Streptozotocin-induced type 1-like diabetic rats Transcription Transducer and activator of transcription 3 Western blotting
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