Moisture-Induced Amorphous Phase Separation of Amorphous Solid Dispersions: Molecular Mechanism, Microstructure, and Its Impact on Dissolution Performance

Amorphous phase separation (APS) is commonly observed in amorphous solid dispersions (ASD) when exposed to moisture. The objective of this study was to investigate: (1) the phase behavior of amorphous solid dispersions composed of a poorly water-soluble drug with extremely low crystallization propen...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 2018-01, Vol.107 (1), p.317-326
Hauptverfasser:	Chen, Huijun, Pui, Yipshu, Liu, Chengyu, Chen, Zhen, Su, Ching-Chiang, Hageman, Michael, Hussain, Munir, Haskell, Roy, Stefanski, Kevin, Foster, Kimberly, Gudmundsson, Olafur, Qian, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	amorphous Crystallization - methods dissolution rate Drug Liberation - drug effects Drug Stability drug-excipient interaction Humidity Hydrophobic and Hydrophilic Interactions physical stability Polymers - chemistry Polyvinyls - chemistry Pyrrolidines - chemistry solid dispersion Solubility Urea - analogs & derivatives Urea - chemistry Valine - analogs & derivatives Valine - chemistry Water - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!