Absence of vitamin D receptor in mature osteoclasts results in altered osteoclastic activity and bone loss

•The deletion of vitamin D receptor in osteoclasts results in femoral bone loss.•Osteoclast-specific VDRKO mice exhibit a marked reduction in thin trabeculae bone following OVX.•Osteoclast-specific VDRKO mice exhibited enhanced expression of osteoclast markers of activity in in vitro cultures. Matur...

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