Mechanistic Basis for Inflammation and Tumor Promotion in Lungs of 2,6-Di-tert-butyl-4-methylphenol-Treated Mice: Electrophilic Metabolites Alkylate and Inactivate Antioxidant Enzymes

An established model for mechanistic analysis of lung carcinogenesis involves administration of 3-methylcholanthrene to mice followed by several weekly injections of the tumor promoter 2,6-di-tert-butyl-4-methylphenol (BHT). BHT is metabolized to quinone methides (QMs) responsible for promoting tumo...

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Veröffentlicht in:	Chemical research in toxicology 2007-02, Vol.20 (2), p.199-207
Hauptverfasser:	Meier, Brent W, Gomez, Jose D, Kirichenko, Oleg V, Thompson, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases - antagonists & inhibitors Alcohol Oxidoreductases - chemistry Alcohol Oxidoreductases - metabolism Aldehyde Reductase Aldo-Keto Reductases Alkylation Animals Antioxidants - chemistry Antioxidants - metabolism Chromatography, Liquid - methods Dose-Response Relationship, Drug Electrophoresis, Gel, Two-Dimensional - methods Indolequinones - chemistry Indolequinones - metabolism Indolequinones - pharmacology Inflammation - chemically induced Injections, Intraperitoneal Lung Neoplasms - chemically induced Male Mass Spectrometry - methods Mice Mice, Inbred BALB C Molecular Structure Peroxidases - antagonists & inhibitors Peroxidases - chemistry Peroxidases - metabolism Peroxiredoxin VI Peroxiredoxins Phenols - administration & dosage Phenols - metabolism Phenols - toxicity Reactive Oxygen Species - metabolism Selenium-Binding Proteins - antagonists & inhibitors Selenium-Binding Proteins - chemistry Selenium-Binding Proteins - metabolism Sensitivity and Specificity Superoxide Dismutase - antagonists & inhibitors Superoxide Dismutase - chemistry Superoxide Dismutase - metabolism
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