Mechanism of sodium hydrosulfide modulation of L-type calcium channels in rat colonic smooth muscle cells

Hydrogen sulfide (H2S) can exert different effects on the gastrointestinal tract by modulating ion channels. Previously, we found that H2S donor sodium hydrosulfide (NaHS) regulates colonic motility through L-type calcium channels, but the molecular mechanism remains unknown. The present study was d...

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Veröffentlicht in:	European journal of pharmacology 2018-01, Vol.818, p.356-363
Hauptverfasser:	Tang, Qincai, Quan, Xiaojing, Yan, Lin, Ren, Haixia, Chen, Wei, Xia, Hong, Luo, Hesheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Channels, L-Type - metabolism Colon Colon - cytology Colon - drug effects Colon - metabolism Colon - physiology Gastrointestinal Motility - drug effects L-type calcium channels Male Muscle Contraction - drug effects Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Rats Rats, Wistar Smooth muscle cells Sulfides - pharmacology Whole-cell patch-clamp
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