Cyclodextrin-based oral dissolving films formulation of taste-masked meloxicam
This work deals with fast-dissolving drug delivery systems of meloxicam (MX) derived from electrospun polyvinylpyrrolidone (PVP)/2-hydroxypropyl-β-cyclodextrin (HPβCD) nanofiber mats. Electrospinning of solutions with different solvent systems [dimethylformamide (DMF) and ethyl alcohol (EtOH)] was p...
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| Veröffentlicht in: | Pharmaceutical development and technology 2018-06, Vol.23 (5), p.530-539 |
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| creator | Samprasit, Wipada Akkaramongkolporn, Prasert Kaomongkolgit, Ruchadaporn Opanasopit, Praneet |
| description | This work deals with fast-dissolving drug delivery systems of meloxicam (MX) derived from electrospun polyvinylpyrrolidone (PVP)/2-hydroxypropyl-β-cyclodextrin (HPβCD) nanofiber mats. Electrospinning of solutions with different solvent systems [dimethylformamide (DMF) and ethyl alcohol (EtOH)] was performed. Prepared films were evaluated for morphology, physical, and mechanical properties. MX content, dissolving time, MX release, and cytotoxicity of films were investigated. In vivo studies were also performed in healthy human volunteers. The results showed that MX/HPβCD complexes improved the solubility of MX. PVP also increased MX solubility and the stability of MX/HPβCD complexes. Films were successfully prepared by two solvent systems with fiber in the nanometer range. MX was well incorporated into the films (100% efficiency). The X-ray patterns and DSC experiment indicated an amorphous form of MX. A fast disintegration time and burst release of MX was obtained from EtOH system. Cytotoxicity testing of the films produced by EtOH system proved safer than the DMF system. In vivo studies revealed that films rapidly dissolved in the mouth and had a less bitter taste than MX. These results suggest that electospun films from EtOH system may be a good candidate for fast-dissolving drug delivery systems to increase palatability of dosage forms. |
| doi_str_mv | 10.1080/10837450.2017.1401636 |
| format | Article |
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Electrospinning of solutions with different solvent systems [dimethylformamide (DMF) and ethyl alcohol (EtOH)] was performed. Prepared films were evaluated for morphology, physical, and mechanical properties. MX content, dissolving time, MX release, and cytotoxicity of films were investigated. In vivo studies were also performed in healthy human volunteers. The results showed that MX/HPβCD complexes improved the solubility of MX. PVP also increased MX solubility and the stability of MX/HPβCD complexes. Films were successfully prepared by two solvent systems with fiber in the nanometer range. MX was well incorporated into the films (100% efficiency). The X-ray patterns and DSC experiment indicated an amorphous form of MX. A fast disintegration time and burst release of MX was obtained from EtOH system. Cytotoxicity testing of the films produced by EtOH system proved safer than the DMF system. In vivo studies revealed that films rapidly dissolved in the mouth and had a less bitter taste than MX. These results suggest that electospun films from EtOH system may be a good candidate for fast-dissolving drug delivery systems to increase palatability of dosage forms.</description><identifier>ISSN: 1083-7450</identifier><identifier>EISSN: 1097-9867</identifier><identifier>DOI: 10.1080/10837450.2017.1401636</identifier><identifier>PMID: 29103353</identifier><language>eng</language><publisher>England</publisher><subject>Administration, Oral ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics ; beta-Cyclodextrins - chemistry ; Cell Line ; Dimethylformamide - chemistry ; Drug Delivery Systems - methods ; Drug Liberation ; Humans ; Nanofibers - chemistry ; Povidone - chemistry ; Solubility ; Taste ; Tensile Strength ; Thiazines - administration & dosage ; Thiazines - chemistry ; Thiazines - pharmacokinetics ; Thiazoles - administration & dosage ; Thiazoles - chemistry ; Thiazoles - pharmacokinetics ; X-Ray Diffraction</subject><ispartof>Pharmaceutical development and technology, 2018-06, Vol.23 (5), p.530-539</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c309t-34216f3b7394f738a3c91cabc0bd0fb8d83bfc1524c4747f7552dc87594404663</citedby><cites>FETCH-LOGICAL-c309t-34216f3b7394f738a3c91cabc0bd0fb8d83bfc1524c4747f7552dc87594404663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29103353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samprasit, Wipada</creatorcontrib><creatorcontrib>Akkaramongkolporn, Prasert</creatorcontrib><creatorcontrib>Kaomongkolgit, Ruchadaporn</creatorcontrib><creatorcontrib>Opanasopit, Praneet</creatorcontrib><title>Cyclodextrin-based oral dissolving films formulation of taste-masked meloxicam</title><title>Pharmaceutical development and technology</title><addtitle>Pharm Dev Technol</addtitle><description>This work deals with fast-dissolving drug delivery systems of meloxicam (MX) derived from electrospun polyvinylpyrrolidone (PVP)/2-hydroxypropyl-β-cyclodextrin (HPβCD) nanofiber mats. Electrospinning of solutions with different solvent systems [dimethylformamide (DMF) and ethyl alcohol (EtOH)] was performed. Prepared films were evaluated for morphology, physical, and mechanical properties. MX content, dissolving time, MX release, and cytotoxicity of films were investigated. In vivo studies were also performed in healthy human volunteers. The results showed that MX/HPβCD complexes improved the solubility of MX. PVP also increased MX solubility and the stability of MX/HPβCD complexes. Films were successfully prepared by two solvent systems with fiber in the nanometer range. MX was well incorporated into the films (100% efficiency). The X-ray patterns and DSC experiment indicated an amorphous form of MX. A fast disintegration time and burst release of MX was obtained from EtOH system. Cytotoxicity testing of the films produced by EtOH system proved safer than the DMF system. In vivo studies revealed that films rapidly dissolved in the mouth and had a less bitter taste than MX. These results suggest that electospun films from EtOH system may be a good candidate for fast-dissolving drug delivery systems to increase palatability of dosage forms.</description><subject>Administration, Oral</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</subject><subject>beta-Cyclodextrins - chemistry</subject><subject>Cell Line</subject><subject>Dimethylformamide - chemistry</subject><subject>Drug Delivery Systems - methods</subject><subject>Drug Liberation</subject><subject>Humans</subject><subject>Nanofibers - chemistry</subject><subject>Povidone - chemistry</subject><subject>Solubility</subject><subject>Taste</subject><subject>Tensile Strength</subject><subject>Thiazines - administration & dosage</subject><subject>Thiazines - chemistry</subject><subject>Thiazines - pharmacokinetics</subject><subject>Thiazoles - administration & dosage</subject><subject>Thiazoles - chemistry</subject><subject>Thiazoles - pharmacokinetics</subject><subject>X-Ray Diffraction</subject><issn>1083-7450</issn><issn>1097-9867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1PAyEQhonR2Fr9CZo9etkKCyxwNI1fSaMXPROWBYPCUmHXtP_e3bT1MjOH95nJPABcI7hEkMO7sWBGKFxWELElIhDVuD4BcwQFKwWv2ek0c1xOoRm4yPkLQsQFpOdgVgkEMaZ4Dl5XO-1ja7Z9cl3ZqGzaIibli9blHP2v6z4L63zIhY0pDF71LnZFtEWvcm_KoPL3SATj49ZpFS7BmVU-m6tDX4CPx4f31XO5fnt6Wd2vS42h6EtMKlRb3DAsiGWYK6wF0qrRsGmhbXjLcWM1ohXRhBFmGaVVqzmjghBI6hovwO1-7ybFn8HkXgaXtfFedSYOWSJRjx8SQcQYpfuoTjHnZKzcJBdU2kkE5aRSHlXKSaU8qBy5m8OJoQmm_aeO7vAfWuZuwQ</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Samprasit, Wipada</creator><creator>Akkaramongkolporn, Prasert</creator><creator>Kaomongkolgit, Ruchadaporn</creator><creator>Opanasopit, Praneet</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201806</creationdate><title>Cyclodextrin-based oral dissolving films formulation of taste-masked meloxicam</title><author>Samprasit, Wipada ; Akkaramongkolporn, Prasert ; Kaomongkolgit, Ruchadaporn ; Opanasopit, Praneet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-34216f3b7394f738a3c91cabc0bd0fb8d83bfc1524c4747f7552dc87594404663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Administration, Oral</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</topic><topic>beta-Cyclodextrins - chemistry</topic><topic>Cell Line</topic><topic>Dimethylformamide - chemistry</topic><topic>Drug Delivery Systems - methods</topic><topic>Drug Liberation</topic><topic>Humans</topic><topic>Nanofibers - chemistry</topic><topic>Povidone - chemistry</topic><topic>Solubility</topic><topic>Taste</topic><topic>Tensile Strength</topic><topic>Thiazines - administration & dosage</topic><topic>Thiazines - chemistry</topic><topic>Thiazines - pharmacokinetics</topic><topic>Thiazoles - administration & dosage</topic><topic>Thiazoles - chemistry</topic><topic>Thiazoles - pharmacokinetics</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Samprasit, Wipada</creatorcontrib><creatorcontrib>Akkaramongkolporn, Prasert</creatorcontrib><creatorcontrib>Kaomongkolgit, Ruchadaporn</creatorcontrib><creatorcontrib>Opanasopit, Praneet</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmaceutical development and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samprasit, Wipada</au><au>Akkaramongkolporn, Prasert</au><au>Kaomongkolgit, Ruchadaporn</au><au>Opanasopit, Praneet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclodextrin-based oral dissolving films formulation of taste-masked meloxicam</atitle><jtitle>Pharmaceutical development and technology</jtitle><addtitle>Pharm Dev Technol</addtitle><date>2018-06</date><risdate>2018</risdate><volume>23</volume><issue>5</issue><spage>530</spage><epage>539</epage><pages>530-539</pages><issn>1083-7450</issn><eissn>1097-9867</eissn><abstract>This work deals with fast-dissolving drug delivery systems of meloxicam (MX) derived from electrospun polyvinylpyrrolidone (PVP)/2-hydroxypropyl-β-cyclodextrin (HPβCD) nanofiber mats. Electrospinning of solutions with different solvent systems [dimethylformamide (DMF) and ethyl alcohol (EtOH)] was performed. Prepared films were evaluated for morphology, physical, and mechanical properties. MX content, dissolving time, MX release, and cytotoxicity of films were investigated. In vivo studies were also performed in healthy human volunteers. The results showed that MX/HPβCD complexes improved the solubility of MX. PVP also increased MX solubility and the stability of MX/HPβCD complexes. Films were successfully prepared by two solvent systems with fiber in the nanometer range. MX was well incorporated into the films (100% efficiency). The X-ray patterns and DSC experiment indicated an amorphous form of MX. A fast disintegration time and burst release of MX was obtained from EtOH system. Cytotoxicity testing of the films produced by EtOH system proved safer than the DMF system. In vivo studies revealed that films rapidly dissolved in the mouth and had a less bitter taste than MX. These results suggest that electospun films from EtOH system may be a good candidate for fast-dissolving drug delivery systems to increase palatability of dosage forms.</abstract><cop>England</cop><pmid>29103353</pmid><doi>10.1080/10837450.2017.1401636</doi><tpages>10</tpages></addata></record> |
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| subjects | Administration, Oral Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics beta-Cyclodextrins - chemistry Cell Line Dimethylformamide - chemistry Drug Delivery Systems - methods Drug Liberation Humans Nanofibers - chemistry Povidone - chemistry Solubility Taste Tensile Strength Thiazines - administration & dosage Thiazines - chemistry Thiazines - pharmacokinetics Thiazoles - administration & dosage Thiazoles - chemistry Thiazoles - pharmacokinetics X-Ray Diffraction |
| title | Cyclodextrin-based oral dissolving films formulation of taste-masked meloxicam |
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