Testicular tumors in prepubescent patients
Pediatric testicular tumors are rare, constituting only 1% of all pediatric solid tumors. Single-institution studies addressing pediatric testicular tumors published to date have been limited in the number of patients. We utilized the National Cancer Data Base (1998–2012) to review all prepubescent...
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| Veröffentlicht in: | Journal of pediatric surgery 2018-09, Vol.53 (9), p.1748-1752 |
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| creator | Maizlin, Ilan I. Dellinger, Matthew Gow, Kenneth W. Goldin, Adam B. Goldfarb, Melanie Nuchtern, Jed G. Langer, Monica Vasudevan, Sanjeev A. Doski, John J. Raval, Mehul V. Beierle, Elizabeth A. |
| description | Pediatric testicular tumors are rare, constituting only 1% of all pediatric solid tumors. Single-institution studies addressing pediatric testicular tumors published to date have been limited in the number of patients.
We utilized the National Cancer Data Base (1998–2012) to review all prepubescent patients (≤12 years old) with testicular neoplasms. Demographics, tumor characteristics, treatment modalities, and outcomes were abstracted.
A total of 479 patients were identified, with a median age of 3 years (IQR 0–4) at diagnosis. 67% of cases were diagnosed by 3 years of age. Yolk sac tumors were the most common histology (202 patients, 42.2%). Most tumors were diagnosed at a low stage. Resection was performed in 465 boys, with 75% having undergone radical orchiectomies. Chemotherapy was utilized in 28% of cases and radiotherapy in 7%. With mean follow-up of 5.6 years, mortality rate was 3%. No difference in mortality was noted based on histology or extent of surgical resection.
This series of prepubertal testicular tumors is the largest yet reported and highlights the patient demographics, tumor characteristics, treatment modalities and outcomes for these tumors.
Prognosis study
II. |
| doi_str_mv | 10.1016/j.jpedsurg.2017.09.020 |
| format | Article |
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We utilized the National Cancer Data Base (1998–2012) to review all prepubescent patients (≤12 years old) with testicular neoplasms. Demographics, tumor characteristics, treatment modalities, and outcomes were abstracted.
A total of 479 patients were identified, with a median age of 3 years (IQR 0–4) at diagnosis. 67% of cases were diagnosed by 3 years of age. Yolk sac tumors were the most common histology (202 patients, 42.2%). Most tumors were diagnosed at a low stage. Resection was performed in 465 boys, with 75% having undergone radical orchiectomies. Chemotherapy was utilized in 28% of cases and radiotherapy in 7%. With mean follow-up of 5.6 years, mortality rate was 3%. No difference in mortality was noted based on histology or extent of surgical resection.
This series of prepubertal testicular tumors is the largest yet reported and highlights the patient demographics, tumor characteristics, treatment modalities and outcomes for these tumors.
Prognosis study
II.</description><identifier>ISSN: 0022-3468</identifier><identifier>EISSN: 1531-5037</identifier><identifier>DOI: 10.1016/j.jpedsurg.2017.09.020</identifier><identifier>PMID: 29102152</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Pediatrics ; Prepubescent ; Testes ; Testicular neoplasm ; Tumor</subject><ispartof>Journal of pediatric surgery, 2018-09, Vol.53 (9), p.1748-1752</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-d8e269d2a9d85deb36ed6e80917196f0c8b56e64aeb46783580ad6289bc74ba13</citedby><cites>FETCH-LOGICAL-c368t-d8e269d2a9d85deb36ed6e80917196f0c8b56e64aeb46783580ad6289bc74ba13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022346817306267$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29102152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maizlin, Ilan I.</creatorcontrib><creatorcontrib>Dellinger, Matthew</creatorcontrib><creatorcontrib>Gow, Kenneth W.</creatorcontrib><creatorcontrib>Goldin, Adam B.</creatorcontrib><creatorcontrib>Goldfarb, Melanie</creatorcontrib><creatorcontrib>Nuchtern, Jed G.</creatorcontrib><creatorcontrib>Langer, Monica</creatorcontrib><creatorcontrib>Vasudevan, Sanjeev A.</creatorcontrib><creatorcontrib>Doski, John J.</creatorcontrib><creatorcontrib>Raval, Mehul V.</creatorcontrib><creatorcontrib>Beierle, Elizabeth A.</creatorcontrib><title>Testicular tumors in prepubescent patients</title><title>Journal of pediatric surgery</title><addtitle>J Pediatr Surg</addtitle><description>Pediatric testicular tumors are rare, constituting only 1% of all pediatric solid tumors. Single-institution studies addressing pediatric testicular tumors published to date have been limited in the number of patients.
We utilized the National Cancer Data Base (1998–2012) to review all prepubescent patients (≤12 years old) with testicular neoplasms. Demographics, tumor characteristics, treatment modalities, and outcomes were abstracted.
A total of 479 patients were identified, with a median age of 3 years (IQR 0–4) at diagnosis. 67% of cases were diagnosed by 3 years of age. Yolk sac tumors were the most common histology (202 patients, 42.2%). Most tumors were diagnosed at a low stage. Resection was performed in 465 boys, with 75% having undergone radical orchiectomies. Chemotherapy was utilized in 28% of cases and radiotherapy in 7%. With mean follow-up of 5.6 years, mortality rate was 3%. No difference in mortality was noted based on histology or extent of surgical resection.
This series of prepubertal testicular tumors is the largest yet reported and highlights the patient demographics, tumor characteristics, treatment modalities and outcomes for these tumors.
Prognosis study
II.</description><subject>Pediatrics</subject><subject>Prepubescent</subject><subject>Testes</subject><subject>Testicular neoplasm</subject><subject>Tumor</subject><issn>0022-3468</issn><issn>1531-5037</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkF9LwzAUxYMobk6_wuijCK03SZumb8rwHwx8mc8hTe4kpV1r0gp-ezO2-erTgcu559z7I2RJIaNAxX2TNQPaMPnPjAEtM6gyYHBG5rTgNC2Al-dkDsBYynMhZ-QqhAYgjoFekhmrKDBasDm522AYnZla7ZNx6nofErdLBo_DVGMwuBuTQY8uargmF1vdBrw56oJ8PD9tVq_p-v3lbfW4Tg0XckytRCYqy3RlZWGx5gKtQAkVLWkltmBkXQgUucY6F6XkhQRtBZNVbcq81pQvyO0hd_D91xTPU52Ll7St3mE_BRVTKPCci71VHKzG9yF43KrBu077H0VB7TmpRp04qT0nBZWKnOLi8tgx1R3av7UTmGh4OBgwfvrt0KtgIgWD1nk0o7K9-6_jFzKVfFQ</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Maizlin, Ilan I.</creator><creator>Dellinger, Matthew</creator><creator>Gow, Kenneth W.</creator><creator>Goldin, Adam B.</creator><creator>Goldfarb, Melanie</creator><creator>Nuchtern, Jed G.</creator><creator>Langer, Monica</creator><creator>Vasudevan, Sanjeev A.</creator><creator>Doski, John J.</creator><creator>Raval, Mehul V.</creator><creator>Beierle, Elizabeth A.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201809</creationdate><title>Testicular tumors in prepubescent patients</title><author>Maizlin, Ilan I. ; Dellinger, Matthew ; Gow, Kenneth W. ; Goldin, Adam B. ; Goldfarb, Melanie ; Nuchtern, Jed G. ; Langer, Monica ; Vasudevan, Sanjeev A. ; Doski, John J. ; Raval, Mehul V. ; Beierle, Elizabeth A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-d8e269d2a9d85deb36ed6e80917196f0c8b56e64aeb46783580ad6289bc74ba13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Pediatrics</topic><topic>Prepubescent</topic><topic>Testes</topic><topic>Testicular neoplasm</topic><topic>Tumor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maizlin, Ilan I.</creatorcontrib><creatorcontrib>Dellinger, Matthew</creatorcontrib><creatorcontrib>Gow, Kenneth W.</creatorcontrib><creatorcontrib>Goldin, Adam B.</creatorcontrib><creatorcontrib>Goldfarb, Melanie</creatorcontrib><creatorcontrib>Nuchtern, Jed G.</creatorcontrib><creatorcontrib>Langer, Monica</creatorcontrib><creatorcontrib>Vasudevan, Sanjeev A.</creatorcontrib><creatorcontrib>Doski, John J.</creatorcontrib><creatorcontrib>Raval, Mehul V.</creatorcontrib><creatorcontrib>Beierle, Elizabeth A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maizlin, Ilan I.</au><au>Dellinger, Matthew</au><au>Gow, Kenneth W.</au><au>Goldin, Adam B.</au><au>Goldfarb, Melanie</au><au>Nuchtern, Jed G.</au><au>Langer, Monica</au><au>Vasudevan, Sanjeev A.</au><au>Doski, John J.</au><au>Raval, Mehul V.</au><au>Beierle, Elizabeth A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Testicular tumors in prepubescent patients</atitle><jtitle>Journal of pediatric surgery</jtitle><addtitle>J Pediatr Surg</addtitle><date>2018-09</date><risdate>2018</risdate><volume>53</volume><issue>9</issue><spage>1748</spage><epage>1752</epage><pages>1748-1752</pages><issn>0022-3468</issn><eissn>1531-5037</eissn><abstract>Pediatric testicular tumors are rare, constituting only 1% of all pediatric solid tumors. Single-institution studies addressing pediatric testicular tumors published to date have been limited in the number of patients.
We utilized the National Cancer Data Base (1998–2012) to review all prepubescent patients (≤12 years old) with testicular neoplasms. Demographics, tumor characteristics, treatment modalities, and outcomes were abstracted.
A total of 479 patients were identified, with a median age of 3 years (IQR 0–4) at diagnosis. 67% of cases were diagnosed by 3 years of age. Yolk sac tumors were the most common histology (202 patients, 42.2%). Most tumors were diagnosed at a low stage. Resection was performed in 465 boys, with 75% having undergone radical orchiectomies. Chemotherapy was utilized in 28% of cases and radiotherapy in 7%. With mean follow-up of 5.6 years, mortality rate was 3%. No difference in mortality was noted based on histology or extent of surgical resection.
This series of prepubertal testicular tumors is the largest yet reported and highlights the patient demographics, tumor characteristics, treatment modalities and outcomes for these tumors.
Prognosis study
II.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29102152</pmid><doi>10.1016/j.jpedsurg.2017.09.020</doi><tpages>5</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Pediatrics Prepubescent Testes Testicular neoplasm Tumor |
| title | Testicular tumors in prepubescent patients |
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