Subchronic, Reproductive, and Developmental Toxicity of a Fluorotelomer-Based Urethane Polymeric Product

A commercial fluorotelomer-based urethane polymeric dispersion, consisting of polymer, surfactant, and water, was evaluated in subchronic, reproduction, and developmental toxicity studies. The dispersion was administered daily by gavage to rats at dosages of 0, 50, 250, or 1000 mg polymer kg day or...

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Veröffentlicht in:	Drug and chemical toxicology (New York, N.Y. 1978) N.Y. 1978), 2008-01, Vol.31 (3), p.317-337
Hauptverfasser:	Stadler, Judith C., Delker, Donald A., Malley, Linda A., Frame, Steven R., Everds, Nancy E., Mylchreest, Eve, Munley, Susan M., Loveless, Scott E., Buck, Robert C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Developmental Dose-Response Relationship, Drug Embryology: invertebrates and vertebrates. Teratology Female Fetus - drug effects Fluorocarbons - administration & dosage Fluorocarbons - toxicity Fluorotelomer-based urethane polymer Fundamental and applied biological sciences. Psychology Liver - drug effects Liver - enzymology Male Medical sciences Nasal Mucosa - pathology Necrosis - chemically induced No-Observed-Adverse-Effect Level Organ Size - drug effects Polymers - administration & dosage Polymers - toxicity Pregnancy Rat Rats Rats, Sprague-Dawley Reproduction Reproduction - drug effects Subchronic Surface-Active Agents - administration & dosage Surface-Active Agents - toxicity Teratology. Teratogens Thyroid Gland - drug effects Thyroid Gland - metabolism Tissue Adhesions - chemically induced Toxicity Tests Toxicology Urethane - administration & dosage Urethane - toxicity Various organic compounds
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