Thyroid hormone induces cyclin D1 nuclear translocation and DNA synthesis in adult rat cardiomyocytes

Although mammalian cardiomyocytes lose their proliferative capacity after birth, there is evidence that postmitotic cardiomyocytes can proliferate provided that cyclin D1 accumulates in the nucleus. Here we show by Northern blot, Western analysis, and immunohistochemistry that 3,5,3'-triiodothy...

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Veröffentlicht in:	The FASEB journal 2006, Vol.20 (1), p.87-94
Hauptverfasser:	Ledda-Columbano, Giovanna M, Molotzu, Francesca, Pibiri, Monica, Cossu, Costanza, Perra, Andrea, Columbano, Amedeo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BrdU Bromodeoxyuridine - metabolism Cardiomegaly - chemically induced Cell Cycle - drug effects Cell Nucleus - drug effects Cell Nucleus - metabolism Creatine Kinase - blood Creatinine - blood Cyclin D1 - metabolism cyclins DNA - biosynthesis DNA Replication - drug effects L-Lactate Dehydrogenase - blood Male Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Protein Transport - drug effects Rats Rats, Inbred F344 RNA, Messenger - metabolism Triiodothyronine - pharmacology
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