Indoxyl 3-sulfate inhibits maturation and activation of human monocyte-derived dendritic cells

•Viability of human dendritic cells is preserved even in a high indoxyl 3-sulfate environment.•Indoxyl 3-sulfate treatment induces tolerogenic DCs, secreting less IL-12 but more anti-inflammatory IL-10.•Indoxyl 3-sulfate induced tolerogenic DCs modulate T cell activation resulting in strongly reduce...

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Veröffentlicht in:	Immunobiology (1979) 2018-02, Vol.223 (2), p.239-245
Hauptverfasser:	Ghimire, Sakhila, Matos, Carina, Caioni, Massimiliano, Weber, Daniela, Peter, Katrin, Holler, Ernst, Kreutz, Marina, Renner, Kathrin
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - pharmacology B7-1 Antigen - metabolism B7-2 Antigen - metabolism Cell Differentiation Cells, Cultured Coculture Techniques Cytokines - metabolism Dendritic Cells - immunology Humans IFNɣ IL-12 Immune Tolerance Indican - metabolism Indoxyl 3-sulfate Lymphocyte Activation Monocytes - immunology T cells T-Lymphocytes - immunology TNF Tolerogenic dendritic cells Tryptophan - metabolism
Online-Zugang:	Volltext
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