Garcinia mangostana Linn displays antidepressant-like and pro-cognitive effects in a genetic animal model of depression: a bio-behavioral study in the Flinders Sensitive Line rat

There is abundant evidence for both disorganized redox balance and cognitive deficits in major depressive disorder (MDD). Garcinia mangostana Linn (GM) has anti-oxidant activity. We studied the antidepressant-like and pro-cognitive effects of raw GM rind in Flinders Sensitive Line (FSL) rats, a gene...

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Veröffentlicht in:	Metabolic brain disease 2018-04, Vol.33 (2), p.467-480
Hauptverfasser:	Oberholzer, Inge, Möller, Marisa, Holland, Brendan, Dean, Olivia M., Berk, Michael, Harvey, Brian H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Animal cognition Animals Antidepressants Antidepressive Agents - pharmacology Behavior, Animal - drug effects Biochemistry Biomedical and Life Sciences Biomedicine Cognition - drug effects Cognitive ability Cortex (frontal) Depression - drug therapy Disease Models, Animal Garcinia mangostana Garcinia mangostana - drug effects Hippocampus Imipramine Imipramine - pharmacology Lipid peroxidation Male Malondialdehyde Mental depression Metabolic Diseases Motor Activity - drug effects Neurology Neurosciences Noradrenaline Norepinephrine Object recognition Oncology Open-field behavior Original Article Oxidative stress Pattern recognition Peroxidation Rats Rodents
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