Conscious and anesthetized non-human primate safety pharmacology models: Hemodynamic sensitivity comparison

Drug-induced cardiovascular effects identified in conscious cynomolgus monkeys equipped with tethers and prepared for radiotelemetry were compared with results from anesthetized non-human primate (cynomolgus and rhesus) models. Remifentanil (4.0 μg/kg, bolus), esmolol (2.0 mg/kg, bolus) and dopamine...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 2008-09, Vol.58 (2), p.94-98
Hauptverfasser:	Authier, S., Tanguay, J.F., Fournier, S., Gauvin, D., Legaspi, M., Chaurand, F., Breault, C., Troncy, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - adverse effects Anesthesia Anesthetized Animals Blood pressure Cardiovascular Conscious Consciousness Cynomolgus Dopamine - adverse effects Female Hemodynamics - drug effects Hypnotics and Sedatives - adverse effects Macaca fascicularis Male Monkey Pharmacology Piperidines - adverse effects Propanolamines - adverse effects Safety Sensitivity Sympathomimetics - adverse effects Telemetry
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