Molecular detection of exercise-induced free radicals following ascorbate prophylaxis in type 1 diabetes mellitus: a randomised controlled trial

Aims/hypothesis Patients with type 1 diabetes mellitus are more susceptible than healthy individuals to exercise-induced oxidative stress and vascular endothelial dysfunction, which has important implications for the progression of disease. Thus, in the present study, we designed a randomised double...

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Veröffentlicht in:	Diabetologia 2008-11, Vol.51 (11), p.2049-2059
Hauptverfasser:	Davison, G. W, Ashton, T, George, L, Young, I. S, McEneny, J, Davies, B, Jackson, S. K, Peters, J. R, Bailey, D. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adolescent Adult Antioxidants ascorbic acid Ascorbic Acid - therapeutic use Biological and medical sciences Body Mass Index Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy Diabetes. Impaired glucose tolerance Disease prevention Double-Blind Method electron paramagnetic resonance spectroscopy Electron Spin Resonance Spectroscopy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Energy Metabolism Etiopathogenesis. Screening. Investigations. Target tissue resistance Exercise - physiology Free radicals Free Radicals - blood Free Radicals - metabolism glucose Glycated Hemoglobin A - metabolism Human Physiology Humans Hypoglycemic Agents - therapeutic use Hypotheses Insulin - therapeutic use Internal Medicine Lipid peroxidation Lipids Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Oxidative stress Oxidative Stress - drug effects Patient Selection Reference Values Type 1 diabetes mellitus Vitamin C
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