New soft alkylating agents with enhanced cytotoxicity against cancer cells resistant to chemotherapeutics and hypoxia

Chloroethylureas (CEU) are soft alkylating agents that covalently bind to beta-tubulin (betaTAC) and affect microtubule polymerization dynamics. Herein, we report the identification of a CEU subset and its corresponding oxazolines, which induce cell growth inhibition, apoptosis, and microtubule disr...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-03, Vol.67 (5), p.2306-2316
Hauptverfasser:	PATENAUDE, Alexandre, DESCHESNES, Réna G, ROUSSEAU, Jean L. C, PETITCLERC, Eric, LACROIX, Jacques, COTE, Marie-France, GAUDREAULT, René C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents, Alkylating - chemistry Antineoplastic Agents, Alkylating - therapeutic use Biological and medical sciences Cell Hypoxia CHO Cells Cricetinae Cricetulus Drug Resistance, Neoplasm - drug effects Drug Screening Assays, Antitumor Electron Transport - drug effects HT29 Cells Humans Medical sciences Microtubules - drug effects Models, Biological Neoplasms - drug therapy Pharmacology. Drug treatments Phenylurea Compounds - therapeutic use Tubulin - metabolism Tumor Cells, Cultured Tumors
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