Article: Thymocyte Proliferation Induced by Pre-T Cell Receptor Signaling Is Maintained through Polycomb Gene Product Bmi-1-Mediated Cdkn2a Repression

Thymocytes undergo massive proliferation before T cell receptor (TCR) gene rearrangement, ensuring the diversification of the TCR repertoire. Because activated cells are more susceptible to damage, cell-death restraint as well as promotion of cell-cycle progression is considered important for adequa...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2008-02, Vol.28 (2), p.231-245
Hauptverfasser:	Miyazaki, Masaki, Miyazaki, Kazuko, Itoi, Manami, Katoh, Yuko, Guo, Yun, Kanno, Rieko, Katoh-Fukui, Yuko, Honda, Hiroaki, Amagai, Takashi, van Lohuizen, Maarten, Kawamoto, Hiroshi, Kanno, Masamoto
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!