TrkA Receptor Activation by Nerve Growth Factor Induces Shedding of the p75 Neurotrophin Receptor Followed by Endosomal γ-Secretase-mediated Release of the p75 Intracellular Domain

Neurotrophins are trophic factors that regulate important neuronal functions. They bind two unrelated receptors, the Trk family of receptor-tyrosine kinases and the p75 neurotrophin receptor (p75). p75 was recently identified as a new substrate for γ-secretase-mediated intramembrane proteolysis, gen...

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Veröffentlicht in:	The Journal of biological chemistry 2007-03, Vol.282 (10), p.7606-7615
Hauptverfasser:	Urra, Soledad, Escudero, Claudia A., Ramos, Patricio, Lisbona, Fernanda, Allende, Edgardo, Covarrubias, Paulina, Parraguez, Jose I., Zampieri, Niccolo, Chao, Moses V., Annaert, Wim, Bronfman, Francisca C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Precursor Protein Secretases - physiology Animals Brain-Derived Neurotrophic Factor - pharmacology Endocytosis Endosomes - metabolism Nerve Growth Factor - pharmacology PC12 Cells Protein Structure, Tertiary Rats Receptor, Nerve Growth Factor - chemistry Receptor, Nerve Growth Factor - metabolism Receptor, trkA - physiology Signal Transduction Tetradecanoylphorbol Acetate - pharmacology
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