Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-β oligomers

Objective Despite progress in defining a pathogenic role for amyloid β protein (Aβ) in Alzheimer's disease, orally bioavailable compounds that prevent its effects on hippocampal synaptic plasticity and cognitive function have not yet emerged. A particularly attractive therapeutic strategy is to...

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Veröffentlicht in:	Annals of neurology 2006-12, Vol.60 (6), p.668-676
Hauptverfasser:	Townsend, Matthew, Cleary, James P., Mehta, Tapan, Hofmeister, Jacki, Lesne, Sylvain, O'Hare, Eugene, Walsh, Dominic M., Selkoe, Dennis J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - toxicity Animals Biological and medical sciences Brain - drug effects Brain - metabolism Brain - physiopathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Dose-Response Relationship, Drug Female Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiopathology Human Injections, Intraventricular Inositol - pharmacology Inositol - therapeutic use Learning - drug effects Learning - physiology Learning. Memory Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Medical sciences Memory Memory Disorders - drug therapy Memory Disorders - metabolism Memory Disorders - physiopathology Mice Neurology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Organ Culture Techniques Peptide Fragments - antagonists & inhibitors Peptide Fragments - metabolism Peptide Fragments - toxicity Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Stereoisomerism Time Factors
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